Periodontal Health in Rare Kidney Conditions and Controls

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This cross-sectional, case-control study will compare the prevalence and severity of periodontal disease among people with Alport syndrome, Fabry disease, tuberous sclerosis complex, SLE with kidney involvement, CKD of non-rare etiology, and non-CKD controls. Participants will have a single visit with a full-mouth periodontal exam, a structured questionnaire, and extraction of relevant medical data. Outcomes include prevalence of periodontitis, disease severity, gingivitis, xerostomia, and potential associations with kidney function and immunosuppressive exposure. Analyses will use descriptive statistics, group comparisons, and multivariable models adjusting for confounders.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Ability to provide written informed consent
* At least 10 natural teeth present
* Belonging to one of the predefined study groups:

  1. Alport syndrome (genetically or clinically confirmed)
  2. Fabry disease (enzymatically or genetically confirmed)
  3. Tuberous sclerosis complex (according to established clinical or genetic criteria)
  4. Systemic lupus erythematosus defined according to the 2019 EULAR/ACR or SLICC 2012 classification criteria, with renal involvement defined by at least one of the following: \[1\] Biopsy-proven lupus nephritis, \[2\] Persistent proteinuria (\>0.5 g/day or equivalent), \[3\] Active urinary sediment (hematuria and/or cellular casts) consistent with lupus nephritis
  5. Chronic kidney disease (CKD) of non-rare etiology: defined according to KDIGO criteria (eGFR \<60 ml/min/1.73 m² and/or markers of kidney damage)
  6. Individuals without CKD, recruited from clinical or dental care settings as non-CKD controls

Exclusion Criteria:

* Periodontal treatment within the last 6 months
* Antibiotic therapy within the last 4 weeks
* Pregnancy
* Conditions precluding periodontal examination
* Inability to comply with study procedures

Where it's running

• Fundeni Clinical Institute
  Bucharest, Romania Recruiting

Study contacts

• Principal investigator: Bahtiar Ismail, MD, PhD — Emergency University Hospital Bucharest
• Study coordinator: Stefan N Lujinschi, MD, PhD candidate
• Email: stefanlujinschi@gmail.com
• Phone: +40728102643

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Salivary biomarkers and periodontal disease progression

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• Candida albicans and periodontitis in Syrian patients

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  Recruiting Al-Hawash Private University · Homs · NCT07574827

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.