Research on biological samples related to periodontitis and inflammation
Official title: Characterization of the Immuno-inflammatory Response Involved in Bone Destruction During Periodontitis: Study on Biological Samples With Collection
Run by Assistance Publique - Hôpitaux de Paris · NCT06012019 · Data updated 2026-11-12
This study is collecting samples from patients with gum disease and healthy individuals to see what causes periodontitis and how to spot it early.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Ivry-sur-Seine) |
| Status | Recruiting |
| Started | April 30, 2025 |
| Main results expected | May 15, 2028 |
| Study ends | May 15, 2028 |
| Registry record updated | August 24, 2025 |
| Trial ID | NCT06012019 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 years old with varying degrees of periodontal health, specifically those with gingivitis, periodontitis, or healthy periodontium.
✕Probably not a fit
Patients with recent antibiotic or anti-inflammatory treatment, or those with specific neutrophil dysfunctions, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to collect biological samples from patients with gingivitis, periodontitis, and healthy controls to better understand the mechanisms that lead to periodontitis. Patients will be recruited from the oral medicine department at Charles Foix Hospital, where tissue, crevicular, salivary, and serum samples will be collected during routine surgical care. The study will analyze neutrophil subtypes and their functions, as well as the presence of specific bacteria associated with oral dysbiosis. The goal is to identify key factors that could help in early detection of patients at risk for periodontitis.
Why it matters
Potential benefit: If successful, this study could lead to improved early identification and management of patients at risk for periodontitis.
How similar studies have gone: While studies on periodontitis and neutrophil function exist, this specific approach focusing on biological sampling and the transition from gingivitis to periodontitis is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Common criteria for all patient groups * Patient \> 18 years old * Patient affiliated to a national health insurance * Patient who speaks and understands French well enough to be able to read and understand the study information note. * Patient who does not object to his participation in the study Specific Criteria : * Control Group = BOP \< 10%, PI\<20%, PD≤ 3mm * Gingivitis cases = BOP ≥ 10%, PD≤ 3mm * Periodontitis cases = BOP ≥ 10%, PD\> 3mm Exclusion Criteria: * Patients who have received antibiotic prophylaxis, antibiotic therapy, or anti-inflammatory treatment within 3 months prior to inclusion * Pregnant or breastfeeding women * Patients suffering from a disease with defective neutrophil number, activity, activation or function * Patient deprived of liberty by judicial or administrative decision.
Where it's running
-
Charles-Foix Hospital
Ivry-sur-Seine, France Recruiting
Study contacts
- Principal investigator: Marjolaine Gosset, PU-PH — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Marjolaine Gosset, PU-PH
- Email: marjolaine.gosset@u-paris.fr
- Phone: 01 49 59 48 11
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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High BMI and periodontitis in Thai adults under 60
This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.
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Periodontal Infection and Inflammatory Markers in Missed Abortion
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Smoking, MFN1, and NLRP3 Levels in Gum Fluid Across Periodontal Health and Disease
This study tests whether smoking changes MFN1 and NLRP3 protein levels in the fluid around the gums for adults with or without periodontitis.
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Dental Loupes vs. Dental Operating Microscope for Non-Surgical Periodontal Treatment
This study tests whether using dental loupes or a dental operating microscope makes non-surgical periodontal cleaning more effective for adults with periodontitis.
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Boron, Oxidative Stress, and Inflammation in Periodontitis
This observational study compares boron levels and inflammation markers in saliva and gum tissue between people with periodontitis and healthy controls to see if boron relates to gum inflammation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.