Research on biological samples related to periodontitis and inflammation
Characterization of the Immuno-inflammatory Response Involved in Bone Destruction During Periodontitis: Study on Biological Samples With Collection
This study is collecting samples from patients with gum disease and healthy individuals to see what causes periodontitis and how to spot it early.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Ivry-sur-Seine) |
| Trial ID | NCT06012019 on ClinicalTrials.gov |
What this trial studies
This observational study aims to collect biological samples from patients with gingivitis, periodontitis, and healthy controls to better understand the mechanisms that lead to periodontitis. Patients will be recruited from the oral medicine department at Charles Foix Hospital, where tissue, crevicular, salivary, and serum samples will be collected during routine surgical care. The study will analyze neutrophil subtypes and their functions, as well as the presence of specific bacteria associated with oral dysbiosis. The goal is to identify key factors that could help in early detection of patients at risk for periodontitis.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years old with varying degrees of periodontal health, specifically those with gingivitis, periodontitis, or healthy periodontium.
Not a fit: Patients with recent antibiotic or anti-inflammatory treatment, or those with specific neutrophil dysfunctions, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early identification and management of patients at risk for periodontitis.
How similar studies have performed: While studies on periodontitis and neutrophil function exist, this specific approach focusing on biological sampling and the transition from gingivitis to periodontitis is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Common criteria for all patient groups * Patient \> 18 years old * Patient affiliated to a national health insurance * Patient who speaks and understands French well enough to be able to read and understand the study information note. * Patient who does not object to his participation in the study Specific Criteria : * Control Group = BOP \< 10%, PI\<20%, PD≤ 3mm * Gingivitis cases = BOP ≥ 10%, PD≤ 3mm * Periodontitis cases = BOP ≥ 10%, PD\> 3mm Exclusion Criteria: * Patients who have received antibiotic prophylaxis, antibiotic therapy, or anti-inflammatory treatment within 3 months prior to inclusion * Pregnant or breastfeeding women * Patients suffering from a disease with defective neutrophil number, activity, activation or function * Patient deprived of liberty by judicial or administrative decision.
Where this trial is running
Ivry-sur-Seine
- Charles-Foix Hospital — Ivry-sur-Seine, France (Recruiting)
Study contacts
- Principal investigator: Marjolaine Gosset, PU-PH — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Marjolaine Gosset, PU-PH
- Email: marjolaine.gosset@u-paris.fr
- Phone: 01 49 59 48 11
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.