Salivary biomarkers and periodontal disease progression
Official title: Evaluation of Salivary Biomarkers Associated With Bone Remodeling in the Transition From Periodontal Health to Disease
Run by Suleyman Demirel University · NCT07661784 · Data updated 2026-11-12
This study tests whether certain salivary biomarkers can reflect progression from healthy gums to gingivitis and periodontitis in adults.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 240 (estimated) |
| Sponsor | Suleyman Demirel University Academic / other |
| Locations | 1 site (Isparta) |
| Status | Recruiting |
| Started | July 10, 2025 |
| Main results expected | July 10, 2026 |
| Study ends | August 30, 2026 |
| Registry record updated | June 22, 2026 |
| Trial ID | NCT07661784 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–65 who are periodontally healthy, have gingivitis, or have periodontitis and can provide informed consent.
✕Probably not a fit
Patients with conditions or treatments known to affect saliva biomarkers or with recent periodontal therapy may not benefit from the biomarker findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study analyzes saliva samples from adults aged 18–65 with periodontal health, gingivitis, or periodontitis. Researchers measure biomarkers related to bone remodeling and inflammation (IL-17, IL-23, IL-6, TGF-β, RANKL, OPG) using ELISA and compare levels across disease stages. The goal is to see if these biomarkers correlate with disease severity and dental parameters, which could support earlier diagnosis and personalized approaches. Participants are classified by established periodontal staging and grading criteria and provide informed consent. The study is conducted at Suleyman Demirel University in Isparta, Turkey.
Why it matters
Potential benefit: If successful, the findings could improve understanding of disease activity and support development of biomarker-based tools for early diagnosis or personalized treatment planning.
How similar studies have gone: Prior research suggests salivary biomarkers can reflect inflammatory and bone remodeling processes in periodontal disease, supporting feasibility of this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Adults aged 18-65 years Systemically healthy individuals Individuals classified as periodontally healthy, gingivitis, or periodontitis according to clinical periodontal examination Ability and willingness to provide informed consent Exclusion Criteria: Presence of systemic diseases affecting periodontal status (e.g., diabetes mellitus, immunological disorders) Use of antibiotics or anti-inflammatory drugs within the last 3 months History of periodontal treatment within the last 6 months Pregnancy or lactation Smoking (optional ) Any condition that may affect salivary biomarker levels
Where it's running
-
Suleyman Demirel University
Isparta, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Erensu Uzar Gürtan, DDS, PhD
- Email: erensu.uzar@icloud.com
- Phone: +90 530 868 1519
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.