Manuka honey mouth rinse for people on hemodialysis with periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 3 interventional study enrolls adults with end-stage renal disease on hemodialysis who have clinical periodontitis. Participants will use either a Manuka honey oral rinse or a normal saline rinse as an adjunct to standard non-surgical periodontal care, and clinical periodontal measures will be tracked over the treatment period. The protocol includes monitoring of oral health outcomes and biomarkers related to inflammation and healing, including fibroblast growth factor-21. Safety, tolerability, and changes in periodontal infection and inflammation are captured as study endpoints.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Both genders, aged above 18 years.
* All patients must be clinically diagnosed of ESRD undergoing hemodialysis.
* All patients must have a periodontal disease.
* Patients must be able to make reliable decision or communications.

Exclusion Criteria:

* Smoking, Alcohol.
* Patient with history of any serious illness as malignancy, who undergo kidney transplant.
* Patients with any autoimmune disease.
* Vulnerable groups such as pregnant females, prisoners, mentally and physically handicapped individuals.
* Known hypersensitivity or severe adverse effects to the treatment drugs or to any ingredient of their preparation.

Where it's running

• Benha hospital
  Banhā, Egypt Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.