Platelet-rich fibrin added to deep tooth cleaning for periodontitis
Platelet Rich Fibrin Adjunctive to Non-surgical Periodontal Therapy: a 6-month Split-mouth Randomized Controlled Clinical Trial
This will try adding platelet-rich fibrin (PRF) to deep non-surgical cleaning to see if it improves gum healing and attachment in adults with stage II–IV periodontitis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Bern Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Bern) |
| Trial ID | NCT07013682 on ClinicalTrials.gov |
What this trial studies
This interventional split-mouth trial compares scaling and root planing (SRP) alone versus SRP plus a PRF membrane applied to treated sites in adults with generalized stage II–IV periodontitis. Clinical outcomes include probing pocket depth, clinical attachment level, plaque and gingival indices, and gingival recession measured at baseline, 7 days, 3 months, and 6 months, with additional assessment of patient-reported pain, bacterial profiles, and inflammatory markers. Participants must have at least 20 teeth and will receive full-mouth non-surgical treatment with PRF applied to one side and SRP alone on the other side. The design tests whether the autologous PRF scaffold can slow epithelial migration and enhance periodontal healing compared with SRP alone.
Who should consider this trial
Good fit: Adults aged 18 and over with generalized stage II–IV periodontitis who have at least 20 teeth and are willing to undergo venipuncture and follow-up visits are ideal candidates.
Not a fit: People who recently had periodontal treatment or antibiotics, who are pregnant or receiving cancer treatment, or who cannot have blood drawn are excluded and unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, adding PRF could increase clinical attachment gain and reduce pocket depth after non-surgical therapy, helping preserve teeth and improve gum health.
How similar studies have performed: Smaller trials and case series have reported improved healing with PRF in periodontal procedures, but results are mixed and high-quality randomized evidence is still limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women aged ≥ 18 years * Periodontitis stage II-IV, grade A/B/C, generalized * Presence of at least 20 teeth (excluding wisdom teeth) * Absence of removable dentures * Patients willing to provide written informed consent and to complete the 6- month study follow-up Exclusion Criteria: * Patients already participating in other clinical trials * Periodontal treatment in the previous 12 months * Antibiotic treatment 3 months prior to study entry * Antibiotic prophylaxis required for dental treatment * Current use of any medication that may affect the clinical features of periodontitis * Pregnant/lactating * Any condition that prevents venipuncture * Not willing to venous puncture * Current cancer treatment * History of radiation in the head-neck area
Where this trial is running
Bern
- Department of Periodontology, University of Bern — Bern, Switzerland (Recruiting)
Study contacts
- Principal investigator: Giovanni Salvi, DMD — University of Bern
- Study coordinator: Alexandra Stähli, DMD
- Email: alexandra.staehli@unibe.ch
- Phone: +41 79 387 15 14
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.