Platelet-rich fibrin added to deep tooth cleaning for periodontitis
Official title: Platelet Rich Fibrin Adjunctive to Non-surgical Periodontal Therapy: a 6-month Split-mouth Randomized Controlled Clinical Trial
Run by University of Bern · NCT07013682 · Data updated 2026-11-12
This will try adding platelet-rich fibrin (PRF) to deep non-surgical cleaning to see if it improves gum healing and attachment in adults with stage II–IV periodontitis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University of Bern Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Bern) |
| Status | Recruiting |
| Started | May 1, 2025 |
| Main results expected | December 24, 2027 |
| Study ends | December 24, 2027 |
| Registry record updated | July 2, 2026 |
| Trial ID | NCT07013682 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 and over with generalized stage II–IV periodontitis who have at least 20 teeth and are willing to undergo venipuncture and follow-up visits are ideal candidates.
✕Probably not a fit
People who recently had periodontal treatment or antibiotics, who are pregnant or receiving cancer treatment, or who cannot have blood drawn are excluded and unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional split-mouth trial compares scaling and root planing (SRP) alone versus SRP plus a PRF membrane applied to treated sites in adults with generalized stage II–IV periodontitis. Clinical outcomes include probing pocket depth, clinical attachment level, plaque and gingival indices, and gingival recession measured at baseline, 7 days, 3 months, and 6 months, with additional assessment of patient-reported pain, bacterial profiles, and inflammatory markers. Participants must have at least 20 teeth and will receive full-mouth non-surgical treatment with PRF applied to one side and SRP alone on the other side. The design tests whether the autologous PRF scaffold can slow epithelial migration and enhance periodontal healing compared with SRP alone.
Why it matters
Potential benefit: If successful, adding PRF could increase clinical attachment gain and reduce pocket depth after non-surgical therapy, helping preserve teeth and improve gum health.
How similar studies have gone: Smaller trials and case series have reported improved healing with PRF in periodontal procedures, but results are mixed and high-quality randomized evidence is still limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women aged ≥ 18 years * Periodontitis stage II-IV, grade A/B/C, generalized * Presence of at least 20 teeth (excluding wisdom teeth) * Absence of removable dentures * Patients willing to provide written informed consent and to complete the 6- month study follow-up Exclusion Criteria: * Patients already participating in other clinical trials * Periodontal treatment in the previous 12 months * Antibiotic treatment 3 months prior to study entry * Antibiotic prophylaxis required for dental treatment * Current use of any medication that may affect the clinical features of periodontitis * Pregnant/lactating * Any condition that prevents venipuncture * Not willing to venous puncture * Current cancer treatment * History of radiation in the head-neck area
Where it's running
-
Department of Periodontology, University of Bern
Bern, Switzerland Recruiting
Study contacts
- Principal investigator: Giovanni Salvi, DMD — University of Bern
- Study coordinator: Alexandra Stähli, DMD
- Email: alexandra.staehli@unibe.ch
- Phone: +41 79 387 15 14
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
JAK1 and JAK2 activation in healthy versus inflamed gums
We will test whether the JAK1 and JAK2 immune-signaling pathways are more active in adults with periodontitis than in adults with healthy gums.
-
Hyaluronic acid and octenidine gel with non-surgical gum treatment
This pilot will test whether adding a hyaluronic acid and octenidine gel to non-surgical periodontal treatment helps adults with advanced periodontitis heal faster and reduce inflammation.
-
Treatment of gum defects using hyaluronic acid and polynucleotides
This study is testing if adding a special gel to gum surgery helps people with gum disease heal better and faster.
-
Comparing two surgical methods for treating periodontitis
This study tests which of two surgical methods works better for people with periodontitis who still have deep pockets around their teeth after initial treatment.
-
High BMI and periodontitis in Thai adults under 60
This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.
-
Association Between Periodontitis and Dry Eye Disease in Adults
This study tests whether periodontitis and dry eye disease are linked by comparing groups with and without each condition.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.