Adjuncts to non-surgical periodontal treatment in smokers and non-smokers with periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, split-mouth, controlled trial compares four subgingival adjuncts used alongside scaling and root planing for stage II–IV periodontitis. The study standardizes adjunct protocols to reduce operator variability and assess efficacy in both smokers and non-smokers. Primary outcomes include probing pocket depth reduction, bleeding on probing, and clinical attachment level gain. The hypothesis is that I-PRF will provide the greatest benefit, particularly in smokers, due to its growth factors and tissue repair effects. The investigation aims to determine which adjunct offers the most consistent improvement over saline irrigation and SRP alone.

Why it matters

Who can join: the full rules

Inclusion: Patients with Stage II-IV Periodontitis; at least one bleeding pocket \> 4 mm minimum in every quadrant.

Exclusion: patients who:

* Pregnant /Lactating
* History of radiotherapy or chemotherapy in the head/neck region.
* Known hypersensitivity to Iodine or Methylene blue solution
* Systematic antibiotic use within the last 30 days
* Long-term use of immunosuppressants or corticosteroids (daily use)
* type 1 / 2 diabetes

Where it's running

• Military Hospital of Instruction of Tunis
  Tunis, Mont Fleury, Tunisia Recruiting

Study contacts

• Principal investigator: hedi chouchene, DDS — Military Hospital of Instruction of Tunis
• Study coordinator: Hela Jegham, DDS - Professor
• Email: hela.jegham@yahoo.fr
• Phone: +21654241521

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.