JAK1 and JAK2 activation in healthy versus inflamed gums

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects gingival biopsy samples from adults with healthy gums and from adults with periodontitis at a single clinic visit. Tissue samples will be analyzed for JAK1 and JAK2 pathway activation and mapped to histological compartments such as epithelium and lamina propria and to specific cell subpopulations. All participants will receive diagnosis and standard dental treatment for their gingival condition. No experimental drug or device is administered.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults
* Sistemically healthy

Exclusion Criteria:

* Active Maliganancy
* History of radiation to the head-neck region
* Chemotherapy or radiation within the last 5 years
* History of hepatitis B/C or HIV infection
* Autoimmune diseases
* Diagnosis of diabetes
* Pregnancy or lactation
* More than 3 hospitalizations over the last 3 years
* Use of systemic antibiotics over the last 3 months
* Use of systemic corticosteroids or immunosuppressants over the last 3 months
* Use of cytokine therapy over the last 3 months
* Use of large doses of pre/probiotic supplements over the last 3 months
* Smoke more than 10 cigarettes per day

Where it's running

• Faculty of Dentistry, University of Chile
  Santiago, Metropolitan Region, Chile Recruiting

Study contacts

• Study coordinator: Nicolas Dutzan, DDS, PhD
• Email: ndutzan@uchile.cl
• Phone: +56934037995

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Platelet-rich fibrin added to deep tooth cleaning for periodontitis

  This will try adding platelet-rich fibrin (PRF) to deep non-surgical cleaning to see if it improves gum healing and attachment in adults with stage II–IV periodontitis.

  Recruiting University of Bern · Bern · NCT07013682

• Hyaluronic acid and octenidine gel with non-surgical gum treatment

  This pilot will test whether adding a hyaluronic acid and octenidine gel to non-surgical periodontal treatment helps adults with advanced periodontitis heal faster and reduce inflammation.

  Recruiting at 2 sites Queen Mary University of London · London and 1 other locations · NCT06522438

• Treatment of gum defects using hyaluronic acid and polynucleotides

  This study is testing if adding a special gel to gum surgery helps people with gum disease heal better and faster.

  Recruiting at 2 sites Queen Mary University of London · London and 1 other locations · NCT06309719

• See if periodontal treatment improves chewing ability and oral quality of life

  This study tests whether treating periodontitis improves how well people can chew and how they feel about their oral health.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07651579

• Candida albicans and periodontitis in Syrian patients

  This project will test whether Candida albicans is commonly present in the gum pockets of Syrian adults with chronic periodontitis.

  Recruiting Al-Hawash Private University · Homs · NCT07574827

• Online self-check to identify your gum disease risk and guide preventive care

  This project will test whether an online questionnaire can accurately identify gum disease risk in adults with natural teeth.

  Recruiting Universiti Sains Malaysia · Abhā, 'Asir Region · NCT07410351

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.