Condition

Periodontal Disease clinical trials and research

• 25Clinical trials
• 46NIH research projects
• 15Countries

Newest Periodontal Disease clinical trials

All recruiting trials (25)

• Autologous Tooth Graft vs. Bovine Xenograft for Healing After Lower Wisdom Tooth Extraction

  This study tests whether using tooth-derived grafts from the extracted tooth or bovine grafts improves healing of periodontal defects after removing impacted lower wisdom teeth, compared to natural blood clot healing.

  Recruiting Universidad Complutense de Madrid · Madrid, Madrid · NCT07824518

• Dental Loupes vs. Dental Operating Microscope for Non-Surgical Periodontal Treatment

  This study tests whether using dental loupes or a dental operating microscope makes non-surgical periodontal cleaning more effective for adults with periodontitis.

  Recruiting Saglik Bilimleri Universitesi · Ankara and 2 other locations · NCT07822269

• Thermosensitive Gel With Octenidine as an Adjunct to Standard Periodontal Cleaning

  This study tests whether PX-Gel, a thermosensitive hyaluronic acid-octenidine gel, added to scaling and root planing helps healing periodontal pockets in adults with periodontitis.

  Recruiting at 2 sites University of Bologna · Bologna, BO and 1 other locations · NCT07725913

• Adjuncts to non-surgical periodontal treatment in smokers and non-smokers with periodontitis

  This trial tests whether adding I-PRF, povidone-iodine, or diode laser to standard deep cleaning helps reduce pocket depth and improve gum health in adults with periodontitis, including smokers.

  Recruiting Phase 4 Military Hospital of Tunis · Tunis, Mont Fleury · NCT07707063

• Omega-3s and low-dose aspirin for smokers with stage III periodontitis

  In adults who smoke and have stage III periodontitis, this study tests whether adding omega-3 fatty acids and a small amount of aspirin to standard cleaning helps improve gum health.

  Recruiting Al-Azhar University · Cairo · NCT07673185

• Minimally Invasive vs Conventional Non-Surgical Periodontal Therapy in Stage III Periodontitis

  This study tests whether a minimally invasive non-surgical approach works as well as the standard cleaning method for people with stage III periodontitis.

  Recruiting Early Phase 1 Mansoura University · Al Mansurah, Dakhlia · NCT07671274

• Salivary biomarkers and periodontal disease progression

  This study tests whether certain salivary biomarkers can reflect progression from healthy gums to gingivitis and periodontitis in adults.

  Recruiting Suleyman Demirel University · Isparta · NCT07661784

• Oral Health Knowledge and Practice Among Italian General Practitioners

  This study tests how well Italian GPs understand oral health and its links to systemic diseases like diabetes and periodontitis, using a nationwide online questionnaire.

  Recruiting University of Roma La Sapienza · Roma, RM · NCT07604493

• Comparing two interdental brush types for adults with periodontal disease

  This will test whether one interdental brush works better than another for adults with periodontal disease over a four-week period.

  Recruiting Pierre Fabre Dermo Cosmetique · Brussels · NCT07575997

• Periodontal Health in Rare Kidney Conditions and Controls

  This study tests how common periodontitis is in people with rare kidney disorders and compares it to CKD patients and people without kidney disease.

  Recruiting Institutul Clinic Fundeni · Bucharest · NCT07575347

• Candida albicans and periodontitis in Syrian patients

  This project will test whether Candida albicans is commonly present in the gum pockets of Syrian adults with chronic periodontitis.

  Recruiting Al-Hawash Private University · Homs · NCT07574827

• Blood markers of stress during periodontal treatment

  This study tests how inflammatory blood markers change during periodontal surgery compared with non-surgical dental care in adults.

  Recruiting Ohio State University · Columbus, Ohio · NCT07468929

• Diode laser added to deep cleaning for gum disease.

  This test will see if adding a 940-nm diode laser to deep cleaning helps adults with periodontal pockets and attachment loss more than deep cleaning alone.

  Recruiting Tel Aviv University · Afula, North · NCT07446127

• Relationship Between Gum Disease and Sleep Quality

  This project will see if periodontitis and saliva inflammation markers (IL-6, IL-10, pentraxin-3) are linked to poorer sleep quality and greater fatigue in adults.

  Recruiting Uskudar University · Istanbul, Istanbul · NCT07421960

• Non‑invasive tests using photos, X‑rays, questionnaires and saliva markers to detect gum disease

  This project will test whether photos, dental X‑rays, questionnaires, and saliva/microbial markers can accurately detect gum disease in adults seeking dental care.

  Recruiting Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Shanghai, Shanghai Municipality and 2 other locations · NCT07406867

• Oral Health Care During Pregnancy to Try to Improve Gum Health and Birth Outcomes

  This study tests two noninvasive ways to improve dental health for pregnant people with gum disease, to see if better oral care can help pregnancy outcomes.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07377344

• Periodontal status, smoking, and salivary inflammasome markers

  This trial will test whether levels of salivary inflammasome proteins (NLRP-3, NLRP-6, NLRP-12, NLRC-5, IL-1β and IL-10) differ between people with and without periodontitis and whether smoking changes those levels.

  Recruiting Uskudar University · Istanbul · NCT07312552

• Lovastatin gel under the gum plus deep cleaning for periodontitis in smokers and non-smokers

  This test sees if placing a 1.2% lovastatin gel under the gum after deep cleaning helps adults with periodontitis, comparing smokers and non-smokers.

  Recruiting Medical University of Silesia · Bielsko-Biala, Silesian Voivodeship · NCT07282756

• Bacillus spore oral spray to prevent and support treatment of gum disease in older adults

  This test tries a Bacillus spore oral spray to see if it cuts harmful mouth bacteria and improves gum health in people aged 35 and older with periodontal disease.

  Recruiting Anabio R&D · Hanoi, Hanoi · NCT07258303

• OROXID oral solution for treating periodontitis

  This trial will test whether using OROXID oral solutions (forte or sensitive) alongside regular dental cleaning helps adults with Stage III, Grade B periodontitis.

  Recruiting at 2 sites ENIKAM d.o.o. · Ljubljana and 1 other locations · NCT07257887

• Lactoferrin oral care to improve gum health during pregnancy

  This will test whether adding a lactoferrin mouthwash to lactoferrin toothpaste plus regular professional cleanings improves gum health in pregnant women 14–28 weeks into pregnancy.

  Recruiting University of Pavia · Pavia, Lombardy · NCT07069140

• Coenzyme Q10 toothpaste with daily Limosilactobacillus reuteri probiotics to improve gum health during pregnancy

  For pregnant women with gum disease, this will try whether adding a CoQ10 toothpaste and daily L. reuteri probiotic to regular cleanings reduces plaque and gum bleeding.

  Recruiting University of Pavia · Pavia, Lombardy · NCT07029360

• Improving dental care for nursing home residents to reduce infections and enhance diabetes control

  This study tests if better dental care for nursing home residents can help reduce infections and improve diabetes control.

  Recruiting Missouri Department of Health and Senior Services · Jefferson City, Missouri · NCT06890676

• Intervention for heart attack patients with gum disease

  This study tests if treating gum disease with surgery can help heart attack patients feel better and improve their recovery.

  Recruiting Shanghai 10th People's Hospital · Shanghai, Shanghai Municipality · NCT06745141

• Investigating the link between oral bacteria and immune system issues in gum disease

  This study is trying to see how genetic immune problems affect gum disease and oral health by looking at people with these issues, those with severe gum disease, and healthy volunteers.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01568697

NIH-funded research (newest 40 of 46)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Precision nanomedicine to calm inflammation and protect bone in gum disease

  A new, targeted nanomedicine approach aims to reduce gum inflammation and prevent bone loss in adults with periodontal disease.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11607783

• Biofilm structure and its role in the start of gum disease

  A researchers team will study how tiny communities of bacteria at the gumline interact with the mouth’s tissues to spark inflammation that leads from healthy gums to periodontal disease.

  NIH research State University of New York at Albany · Albany, United States · NIH-11597609

• Xylitol to Prevent Periodontal Disease and Preterm Birth in Pregnancy and Early Childhood

  A safe, inexpensive chewable gum approach using xylitol is tested to help pregnant people reduce gum disease and lower the chance of preterm birth and related child health problems.

  NIH research University of Washington · Seattle, United States · NIH-11478593

• Periodontal Health in Newborns: Reducing Small Vulnerable Newborn Deaths in Nepal

  A large study in Nepal will test whether a simple oral care package started in early pregnancy can lower the risk of tiny, high-risk newborns dying in their first month.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11478589

• Gingival keratinocyte ferroptosis in periodontal disease pathogenesis

  A study exploring how iron-related cell death in gum cells may drive gum disease and bone loss in periodontitis, and what this could mean for future treatments.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11455064

• Periodontal health and dementia risk in a large health system

  A large health system will study whether gum disease and its treatment relate to Alzheimer’s disease and other dementias over time.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11447646

• Xylitol for Pregnancy Health and Baby Outcomes

  A safe, affordable gum-based treatment using xylitol is being tested to reduce periodontal disease in pregnant people and lower the chance of preterm birth and related child health issues.

  NIH research University of Washington · Seattle, United States · NIH-11416640

• Periodontal health for tiny newborns: a large community trial in Nepal

  A large trial in Nepal will test a simple, low-cost oral care package started in early pregnancy to see if it can reduce deaths and health problems in very small or preterm babies.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11413832

• Biofilm structure and how it starts periodontal disease in humans and dogs

  A scientist team will study how sticky mouth biofilms and special bacteria may start gum disease in adults, using human teeth and dog models.

  NIH research State University of New York at Albany · Albany, United States · NIH-11402600

• How dental plaque structure may trigger gum disease

  Researchers are comparing the arrangement and activity of bacteria in plaque from adults with healthy gums, gingivitis, and periodontitis to learn how plaque changes can start gum disease.

  NIH research State University of New York at Albany · Albany, United States · NIH-11397657

• Automated early bone-loss detection in dental X-rays for timely periodontal care

  A clinician-facing AI tool helps identify subtle bone loss patterns in dental X-rays that are invisible to the naked eye, aiming to enable earlier diagnosis and prevention of periodontitis in adults.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11391295

• TREM2's role in age-related periodontal inflammation and disease

  Researchers want to understand how aging changes the immune response in gums and how TREM2 affects periodontal disease, with a focus on people as they age.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11369194

• Natural products and oral bacteria in gum disease

  Researchers are exploring how natural compounds from oral bacteria influence periodontal disease and how this could lead to targeted, microbiome-friendly treatments.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11367229

• How two mouth bacteria join forces to worsen adult gum disease

  Researchers are testing if stopping cooperation between two common mouth bacteria can lower harmful inflammation in adults with gum disease.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11342135

• T cell responses to a mouth bacteria linked to severe gum disease

  This project will find out whether immune T cells that react to a mouth bacterium called Aggregatibacter actinomycetemcomitans (Aa) help cause tissue and bone damage in adults with severe gum disease.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11325308

• Immune memory cells that may cause gum disease to come back

  This project looks at whether certain immune memory cells in the gums make periodontal disease return, to help people who keep getting gum disease.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11319752

• Nitric-oxide releasing hyaluronic acid therapy for gum disease

  This research tests a nitric-oxide releasing hyaluronic acid gel to kill harmful mouth bacteria, calm inflammation, and help people with periodontitis (advanced gum disease) heal their gums.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11310781

• Investigating how specific immune cells contribute to the recurrence of gum disease

  This study is looking at how certain immune cells in the body might be involved in the return of gum disease, using a special mouse model to see how these cells react to germs and affect gum health over time, which could help us find better ways to treat and prevent gum problems.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11310401

• Saliva test to quickly measure active periodontal disease

  A quick, inexpensive saliva test to detect active tissue destruction from periodontal disease in adults, helping patients and clinicians catch trouble early.

  NIH research Cellectgen, INC. · Pasadena, United States · NIH-11309805

• Investigating T cell responses in a type of gum disease linked to a specific oral bacteria.

  This study is looking at how a specific type of immune cell, called T cells, reacts to a bacteria linked to serious gum disease, using blood samples from patients with this condition, to help us understand how these immune responses might lead to tissue damage in the gums.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11309216

• How age-related changes in blood cells may affect gum disease

  Researchers are testing whether age-related mutant blood cells driven by DNMT3A make gum disease worse in older adults.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11299496

• Medicaid coverage for gum disease treatment and its effects on health

  This project looks at whether expanding Medicaid coverage for gum disease treatment helps adults on Medicaid have better oral and overall health.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11264775

• Type I interferon and gum disease

  Researchers are seeing if a natural immune protein called Type I interferon helps protect adults with periodontitis from bone and tissue loss around the teeth.

  NIH research University of Iowa · Iowa City, United States · NIH-11247132

• Targeting harmful bacteria to improve treatment for gum disease

  This study is exploring a new way to treat gum disease by targeting specific harmful bacteria while keeping the good bacteria in your mouth healthy, which could lead to better results and fewer complications for patients.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11222312

• How sex affects gum disease and type 2 diabetes, with a patient-focused tool

  This project will create easy-to-use summaries and software showing how being male or female relates to gum disease in U.S. adults, including people with type 2 diabetes.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11160773

• How dental plaque structure changes when gums go from healthy to disease

  This project looks at how groups of bacteria in plaque at the gum line change in adults with healthy gums, gingivitis, or chronic periodontitis.

  NIH research State University of New York at Albany · Albany, United States · NIH-11143120

• How Mouth Bacteria Affect Inflammation in Gum Disease

  This project explores how certain bacteria in the mouth produce special molecules that might calm down the body's immune response, potentially leading to long-lasting gum disease.

  NIH research University of Florida · Gainesville, United States · NIH-11122263

• Using nitric oxide to improve treatments for gum disease

  This study is looking at a new treatment for gum disease that uses a special gel to help fight harmful bacteria and reduce inflammation, so patients can heal better and have a more effective way to manage their condition.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11085106

• Investigating how specific bacteria affect oral health and inflammation

  This study is looking at how bad bacteria in your mouth affect your immune system and contribute to gum disease, focusing on a specific protein, and it aims to help us understand how to better protect our oral health.

  NIH research University of Kentucky · Lexington, United States · NIH-11083120

• Understanding B Cells to Help Treat Gum Disease

  This research explores how special immune cells called B10 cells can help calm inflammation and protect against bone loss in gum disease.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-11063838

• Using topical vitamin D to treat periodontal disease

  This study is looking at how putting vitamin D directly on your gums might help treat gum disease by boosting your immune system and reducing inflammation, so if you're dealing with periodontal issues, this could be a promising option for you!

  NIH research University of Louisville · Louisville, United States · NIH-11061026

• The link between aging-related blood cell mutations and gum disease

  This study is looking at how changes in blood stem cells as we get older, especially a common mutation called DNMT3A, might make gum disease worse, helping older adults understand how their age-related blood changes could affect their oral health.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11045687

• Understanding how aging affects bone loss in gum disease

  This study is looking at how aging cells affect bone loss in people with gum disease, and it aims to find out if a special treatment can help improve bone health for those who haven't had success with other options.

  NIH research Augusta University · Augusta, United States · NIH-11040235

• Targeting harmful bacteria to improve treatment for gum disease

  This study is looking at a new way to treat gum disease by targeting specific harmful bacteria while keeping the good bacteria safe, which could help improve your gum health and lower the chances of losing teeth.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11031978

• Evaluating Medicaid coverage for treating gum disease and its health effects

  This study looks at how having Medicaid coverage for gum disease treatment helps improve health, especially for low-income people, by checking how different states cover this care and its effects on oral health and conditions like diabetes.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11031100

• Investigating how Type I Interferon affects gum disease

  This study is looking at how a substance called Type I Interferon affects gum disease and its connection to other health issues like diabetes, with the goal of finding better ways to treat and understand this common condition.

  NIH research University of Iowa · Iowa City, United States · NIH-10991010

• How aging affects the immune system and periodontal disease

  This study is looking at how getting older affects your immune system and how that might impact gum disease, with the goal of finding better ways to help older adults keep their mouths healthy.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10917150

• How sex and gender affect gum disease and diabetes

  This study is looking at how gum disease and diabetes are connected, especially how these issues might affect men and women differently, to help create a tool that can guide people with Type-2 Diabetes on when they should see a dentist for better oral health.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-10916311

• Using AI to find early signs of bone loss in dental X-rays for better diagnosis of gum disease

  This study is working on a smart computer program that helps dentists spot early signs of bone loss in dental X-rays that we can't see ourselves, so they can catch gum disease early and provide better care for patients like you.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-10912052

• Investigating how a specific receptor in mast cells affects gum disease

  This study is looking at a new receptor in mast cells that might play a role in gum disease, and it's for people who want to understand how this could help improve treatments for their periodontal issues.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10902664

Related topics

Quick answers

How many Periodontal Disease clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in Italy (5 trials), Turkey (Türkiye) (4 trials), United States (4 trials), Egypt (2 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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