Lovastatin gel under the gum plus deep cleaning for periodontitis in smokers and non-smokers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with periodontitis receive standard subgingival cleaning (scaling and root planing) and two matched teeth are chosen per person for a split-mouth comparison: one site receives 1.2% lovastatin gel and the other receives a placebo gel. The study enrolls two groups of generally healthy participants: long-term smokers (≥5 years) and non-smokers. Periodontal measurements (pocket depth, clinical attachment level, and other gum health parameters) are recorded before treatment and monitored over follow-up visits to compare healing at medicated versus placebo sites. The design isolates the local effect of lovastatin when used as an adjunct to conventional non-surgical therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* generally healthy patients
* diagnosed periodontal disease (at least one pair of non-adjacent sites with PD≥5 mm or CAL ≥4 mm and vertical bone loss ≥ 3 mm)
* no history of periodontal disease treatment
* no history of antibiotic use in the past 6 months
* an eligible tooth must be alive, with no history of endodontic treatment
* non-smoking (group I) or active smokers (group 2)

Exclusion Criteria:

* Statin allergy
* receiving systemic statin therapy,
* alcoholics
* immunocompromised patients
* pregnant or breastfeeding women.

Where it's running

• Pietrzko Dental Clinic
  Bielsko-Biala, Silesian Voivodeship, Poland Recruiting

Study contacts

• Study coordinator: Magdalena Pietrzko, DMD
• Email: pietrzkoperio@gmail.com
• Phone: +48604796143

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.