Condition

Sarcopenia clinical trials and research

• 125Clinical trials
• 30NIH research projects
• 1New in 30 days
• 31Countries

Newest Sarcopenia clinical trials

All recruiting trials (125)

• Sarcopenia in Patients After Cardiac Surgery

  This observational study tests how common sarcopenia is after cardiac surgery and whether current care helps improve muscle mass and function.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07908472

• Bone marrow mesenchymal stem cell injection for sarcopenia

  This study tests whether CG-BM1, a stem cell injection, can be safely given to adults with sarcopenia to see if it helps improve muscle health.

  Recruiting Phase 1/2 GuangZhou Cellgenes Biotechnology Co., Ltd. · Guangzhou · NCT07865676

• GLP-1 receptor agonist use and muscle health in adults with obesity without diabetes

  This study tests whether GLP-1 receptor agonists affect muscle mass and strength in adults with obesity who don’t have diabetes.

  Recruiting Istanbul Saglik Bilimleri University · Istanbul, Kucukcekmece · NCT07858864

• Sarcopenia and Epidural Steroid Injections in Lumbar Spinal Stenosis

  We’re testing how sarcopenia relates to pain, function, and quality of life after a routine interlaminar epidural steroid injection in people with lumbar spinal stenosis.

  Recruiting Marmara University · Istanbul, Istanbul · NCT07855419

• Using Multimodal Ultrasound to Check Muscle Mass in Metabolic Disease Patients

  This study tests whether a multimodal ultrasound approach can accurately measure muscle mass in people with metabolic syndrome, obesity, sarcopenia, or type 2 diabetes.

  Recruiting Zhangzhou Municipal Hospital · Zhangzhou, Fujian · NCT07836088

• Lower-limb rehabilitation robot training with nutrition education for sarcopenia

  In adults aged 60 and older with sarcopenia, this study tests whether adding robot-assisted leg training to nutrition education can improve muscle mass and walking ability compared with usual care.

  Recruiting Taipei Medical University Hospital · Taipei, Taipei City · NCT07830472

• Preoperative Muscle Health and Postoperative Outcomes in Older Adults with GI Cancer

  This study looks at whether having sarcopenia before surgery affects recovery and complications after GI cancer surgery in people 60 and older.

  Recruiting Van Training and Research Hospital · Van, Van · NCT07817758

• Masseter and Thigh Muscle Ultrasound to Predict Dysphagia and Sarcopenia in Critically Ill Adults

  This study tests whether measuring the masseter muscle with ultrasound can help identify dysphagia in adults after critical illness and extubation, alongside evaluation of sarcopenia.

  Recruiting Hospital General Universitario Gregorio Marañon · Madrid, Madrid · NCT07787312

• Sarcopenia in older adults with acute ischemic stroke

  This study tests how common sarcopenia is in people 50 and older after an acute ischemic stroke and whether having sarcopenia at hospital admission is linked to worse outcomes three months later.

  Recruiting University Clinical Hospital na V.V.Vinogradov (branch of RUDN university na Patrice Lumumba) · Moscow · NCT07764172

• HB05P on Muscle Health: can a pasteurized gut microbe help strength in older adults with sarcopenia

  This study tests whether HB05P capsules can improve muscle strength in adults 50–79 with sarcopenia or possible sarcopenia compared with a placebo over 24 weeks.

  Recruiting Pusan National University Yangsan Hospital · Yangsan · NCT07749118

• Ultrasound-measured thigh muscle thickness and sarcopenia markers in stroke patients

  This study tests whether ultrasound measurements of thigh muscles relate to sarcopenia indicators and fear of movement in people with ischemic stroke.

  Recruiting Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Istanbul, Istanbul · NCT07734506

• Effects of a Community-based Multicomponent Exercise Program on Frailty and Sarcopenia in Older Adults

  This project tests whether a real-world, community-based exercise program helps older adults stay stronger and less frail.

  Recruiting Universidad de Granada · Granada, Andalusia · NCT07732478

• Squat exercise to help pre-sarcopenia in older adults

  Older adults with pre-sarcopenia will try a squat exercise program to see if it can build muscle and improve strength and function.

  Recruiting Tzu Chi University · Taipei · NCT07726758

• Mindfulness during dialysis plus pre-dialysis strength training for sarcopenia in dialysis patients

  This study tests whether adding mindfulness meditation during dialysis to pre-dialysis resistance training helps improve muscle mass and safety in adults undergoing maintenance hemodialysis with sarcopenia.

  Recruiting Ningbo Medical Center Lihuili Hospital · Ningbo · NCT07724587

• Sarcopenia After Bariatric Surgery: Changes in Muscle and Function

  This study tests how bariatric surgery affects muscle mass, strength, and physical performance over time in adults undergoing the procedure.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Istanbul, KÜÇÜKÇEKMECE · NCT07717333

• Digital acupoint therapy plus education and exercise for sarcopenia and sleep in adults

  This trial tests whether a remote program combining traditional Chinese medicine acupoint stimulation, health education, and exercise improves sarcopenia and sleep problems in adults and older adults.

  Recruiting Tainan Hospital, Ministry of Health and Welfare · Tainan · NCT07715721

• Myokines in metabolic and endocrine diseases linked to sarcopenia

  This study tests whether myokines can serve as biomarkers or drivers of sarcopenia and sarcopenic obesity in people with metabolic or endocrine diseases.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Woluwe-Saint-Pierre - Sint-Pieters-Woluwe · NCT07703683

• Muscle Biomarkers and Early Management of Sarcopenia

  This trial tests a non-invasive ultrasound-based method to measure muscle quality and pairs it with a home exercise program to see if it can help people over 50 with sarcopenia or at risk for it.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan, Mi · NCT07692308

• Mental effort with light resistance training for older adults

  This study tests whether adding a mental effort cue to light resistance training helps older adults build more strength and improve neuromuscular function than light training alone.

  Recruiting Kennesaw State University · Kennesaw, Georgia · NCT07687316

• Functional Muscle-Bone Incongruity Index: A look at muscle strength and bone health in adults

  This observational study tests a composite FKUI score using handgrip strength and hip/spine bone density to see if it better reflects musculoskeletal health than each measure alone in adults undergoing routine DXA.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Küçükçekmece, Istanbul · NCT07677033

• Spatial multi-omics and AI-based early warning for pancreatic cancer cachexia

  This study tests whether spatial multi-omics data can reveal how the tumor and body metabolism interact in pancreatic cancer cachexia and whether a multimodal AI model can predict cachexia early in adults with pancreatic ductal adenocarcinoma.

  Recruiting Peking Union Medical College Hospital · Beijing · NCT07670286

• Branched chain amino acids after knee replacement to help muscle

  This trial tests whether giving Livact after knee replacement helps preserve muscle and function in adults with sarcopenia.

  Recruiting at 2 sites Phase 4 Seoul National University Hospital · Seongnam-si, Gyeonggi-do and 2 other locations · NCT07634523

• Creatine with resistance training during GLP-1 therapy

  This study tests if taking creatine while starting GLP-1 weight‑loss treatment helps preserve muscle mass and strength.

  Recruiting University of Saskatchewan · Saskatoon, SK - Saskatchewan · NCT07625202

• TJ0113 Capsule for sarcopenia in adults aged 60 and over

  This study tests whether taking TJ0113 capsules for 26 weeks helps adults with sarcopenia, compared with a placebo.

  Recruiting Phase 2 Hangzhou PhecdaMed Co., Ltd. · Hangzhou, Zhejiang · NCT07620938

• Preoperative Immunonutrition for bone and soft tissue sarcoma patients

  This study tests whether a short course of an oral nutrition supplement before surgery can help patients with bone or soft tissue sarcomas recover better after major tumor-related surgery.

  Recruiting St. Anne's University Hospital Brno, Czech Republic · Brno · NCT07609329

• Even protein distribution plus exercise for people awaiting liver transplant

  This trial tests whether spreading daily protein evenly and combining it with a 12-week exercise program improves nutrition, muscle mass, and function in people waiting for a liver transplant compared with uneven protein timing or usual advice.

  Recruiting at 2 sites Agricultural University of Athens · Athens, Attica and 1 other locations · NCT07561138

• Multicomponent prehabilitation for older adults with breast cancer

  This program will test whether a multicomponent prehabilitation intervention (home-based or supervised) helps people aged 65 and older with breast cancer improve physical function, recovery after surgery, and quality of life while exploring biological markers that predict who benefits.

  Recruiting Fundacion Miguel Servet · Pamplona, Navarre · NCT07531836

• Muscle Health Endotypes in Childhood Cancer Survivors

  This study tests whether adult survivors of childhood cancer have different muscle health endotypes using advanced imaging and neuromuscular testing to guide future targeted interventions.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07531498

• Sarcopenia in older adults with acute heart failure: using muscle ultrasound and biomarkers to predict outcomes

  This study tests whether measuring muscle mass with ultrasound, along with muscle strength and biomarkers, can help predict outcomes for adults 80 and older hospitalized for acute heart failure with preserved ejection fraction.

  Recruiting Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · Madrid, Madrid · NCT07530029

• Pathogenesis and Reversal Strategies for Cancer Cachexia Using Multi-Omics

  This study uses multiple omics methods and nutritional interventions to try to find causes and reversal strategies for cachexia in adults with gastrointestinal cancers.

  Recruiting China Medical University, China · Shenyang, Liaoning · NCT07519837

• Combining nutrition checks and muscle measurements to predict outcomes after lung cancer surgery

  This project will test whether combining nutrition tests and muscle scans can predict recovery, complications, and short-term outcomes in adults having lung cancer surgery.

  Recruiting Ondokuz Mayıs University · Samsun, Samsun · NCT07500376

• Tracking body composition changes after breast cancer treatment

  This project will see how muscle mass and fat distribution change over two years in adults treated for stage I–III breast cancer.

  Recruiting Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation · New Taipei City, Xindian Dist · NCT07472803

• Supervised clinic resistance plus relaxation versus home resistance exercise to improve life after breast cancer

  This trial tests whether a supervised clinic program combining elastic-band resistance exercise and progressive muscle relaxation helps post-treatment breast cancer survivors more than a self-guided home resistance program.

  Recruiting Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation · New Taipei City, Xindian Dist · NCT07465393

• Creatine plus resistance training to improve muscle loss after androgen-deprivation therapy for prostate cancer

  This trial will test whether daily creatine plus supervised resistance training for 12 weeks helps men on androgen-deprivation therapy for prostate cancer keep or restore muscle mass, strength, and physical function compared with training plus placebo.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07463092

• High-intensity interval versus moderate continuous exercise for stroke-related muscle loss

  This will test whether high-intensity interval training (HIIT) or moderate-intensity continuous training (MCIT) better helps people 1–6 months after an ischemic stroke who have muscle loss regain muscle mass, strength, walking ability, and quality of life.

  Recruiting Fenerbahce University · Istanbul, Ataşehir · NCT07456956

• Exercise during hemodialysis to prevent muscle loss and improve sleep

  This trial will test if a 12-week supervised exercise program performed during dialysis can improve muscle mass, strength, physical performance, sleep quality, and quality of life for patients aged 40 and over on chronic hemodialysis.

  Recruiting University of Salamanca · Salamanca, Salamanca · NCT07447375

• Renal rehabilitation with low-dialysate-flow daily hemodialysis for people on hemodialysis

  This tests whether combining a tailored rehab program (exercise + nutrition) with low-dialysate-flow daily hemodialysis helps people on hemodialysis who are at risk of muscle loss (sarcopenia).

  Recruiting Brugmann University Hospital · Brussels · NCT07413315

• Ultrasound to measure muscle quality and fat in older adults during rehab

  We’re testing an ultrasound-based method to see if higher intramuscular fat at the start predicts poorer recovery in physical function for older adults 75+ undergoing rehab.

  Recruiting Nantes University Hospital · Nantes · NCT07411547

• Multimodal exercise program for middle-aged and older adults with diabetic sarcopenia

  This program will try a 12-week multimodal exercise plan with supervised, home-based, and digital support to improve muscle function and metabolic health in people aged 45–85 who have type 2 diabetes and sarcopenia.

  Recruiting Chung Shan Medical University · Taichung, Taiwan · NCT07398495

• MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Help ICU Patients Maintain Muscle Strength

  This trial tests whether adding daily 60-minute thigh electrical muscle stimulation to standard ICU care is safe and easy for adults with sepsis or critical illness to see if it slows ICU-acquired muscle weakness.

  Recruiting at 3 sites Health Discovery Labs · Rochester, Minnesota and 2 other locations · NCT07362862

• Effects of Rehabilitative Exergame Training on Foot Muscle Activity, Balance, and Mobility in Older Adults

  In this study, healthy older adults will try an interactive game-based exercise program to see if it improves foot muscles, balance, and mobility compared with standard balance training.

  Recruiting Tarsus University · Tarsus, Mersi̇n · NCT07357662

• Volunteer-led lifestyle program to help sarcopenia in older adults

  This program tests a digital, volunteer-supported lifestyle plan to improve muscle health and reduce fall risk in older adults with sarcopenia or frailty.

  Recruiting The University of Hong Kong · Hong Kong · NCT07345832

• Gut bacteria patterns in people with sarcopenia and using them to help develop probiotics

  This project will test whether gut bacteria differ between older adults with sarcopenia, age-matched older controls, and younger adults to guide development of probiotics for sarcopenia.

  Recruiting Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT07334210

• Exercise and activity tracking during early treatment for children with ALL to prevent muscle loss and frailty

  This pilot test tries a home-based physical activity and strengthening program with a Fitbit for children aged 5–17 who show early muscle weakness after starting treatment for acute lymphoblastic leukaemia to see if it prevents muscle loss and improves strength compared with usual care.

  Recruiting Murdoch Childrens Research Institute · Melbourne, Victoria · NCT07325305

• Taining Golden Lake comprehensive chronic disease management program

  This project will build a large cohort of adults in Taining County to collect health data and try to create a county-level chronic disease management model for people with hypertension, diabetes, dyslipidemia, and other long-term conditions.

  Recruiting First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT07308314

• Creatine HCl to improve muscle mass and strength in older adults with sarcopenia

  This 12-week randomized, double-blind test will see if daily creatine HCl helps older adults with sarcopenia improve muscle mass, strength, function, and related blood markers.

  Recruiting Center for Health Sciences, Serbia · Belgrade · NCT07285226

• TIPS procedure with or without oral branched-chain amino acids (BCAA)

  This test will try giving oral BCAA supplements for three months after TIPS in adults with cirrhosis and sarcopenia to see if it improves muscle and clinical outcomes.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan · NCT07281846

• Screening for Malnutrition and Sarcopenia in Outpatients

  This project will screen adult outpatients (18+) in hospital clinics in Turkey to see how common the risk of malnutrition and sarcopenia is.

  Recruiting at 69 sites Abbott Nutrition · Sarıçam, Adana and 68 other locations · NCT07256925

• Dietary inflammation, gut microbiome, and muscle loss in older adults

  This project will test whether inflammatory features of people's diets are linked to changes in gut bacteria and to muscle loss in community-dwelling adults aged 60 and over.

  Recruiting LanZhou University · Lanzhou, Gansu · NCT07211321

• Virtual group exercise and health education to lower fall risk in older Veterans with obesity and low muscle

  This program tests whether a live virtual group exercise program plus health education can lower fall risk and increase daily activity for Veterans aged 55 and older with obesity and signs of sarcopenia.

  Recruiting VA Office of Research and Development · Baltimore, Maryland · NCT07206368

• SMILE: Tracking muscle loss, metabolic health, and aging over time

  This project will follow adults to see if combining clinical data, imaging, and blood/tissue samples can detect and track muscle loss and metabolic changes linked to aging.

  Recruiting RenJi Hospital · Shanghai · NCT07205510

• Randomized comparison of whole-body vibration plus usual care versus usual care to improve muscle health in older adults

  This study will test whether adding a four-week, three-times-weekly whole-body vibration program to usual care helps pre-frail and mildly frail adults aged 65 and older improve muscle mass, strength, and function.

  Recruiting Changi General Hospital · Singapore · NCT07205133

• Does age-related muscle loss change rotator cuff tear patterns?

  We will see if age-related muscle loss (sarcopenia) is linked to the location and type of rotator cuff tears in adults aged 40–75 with rotator cuff syndrome.

  Recruiting Haydarpasa Numune Training and Research Hospital · Istanbul, Üsküdar · NCT07183774

• Plant-based diets for healthy aging

  This project will test whether vegetarian and plant-based diets help middle-aged and older Tzu Chi volunteers maintain physical function and cognitive health as they age.

  Recruiting National Health Research Institutes, Taiwan · Dalin, Chiayi · NCT07151365

• Sarcopenia and related risk factors in people with multiple sclerosis

  This study will see how common low muscle mass (sarcopenia) and related factors are in adults with multiple sclerosis.

  Recruiting Selcuk University · Konya, Selcuklu · NCT07116070

• Validating lab assays, IV catheter techniques, and devices for endocrine, cardiometabolic, and musculoskeletal conditions

  This project will test whether laboratory assays, IV catheter methods, and equipment give consistent, reliable results in adults with or without obesity-related, metabolic, or musculoskeletal conditions.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07083557

• AMC6156 for older adults with sarcopenia

  This trial will try once-daily AMC6156 pills or a placebo for 12 weeks to see if they improve strength and mobility in older adults with sarcopenia.

  Recruiting at 4 sites Phase 2 Animuscure Inc. · Seongnam-si, Gyeonggi-do and 3 other locations · NCT07072195

• Silkworm pupa powder to improve nutrition in people with Alzheimer's disease

  This trial will see if daily silkworm pupa powder can improve nutrition, muscle loss, weakness, and thinking in people with Alzheimer's disease.

  Recruiting Zhejiang Hospital · Hangzhou, Zhejiang · NCT07059871

• Multidisciplinary sarcopenia clinic to diagnose and treat muscle loss from COPD

  This project will try a multidisciplinary sarcopenia clinic to see if it improves muscle mass, function, and overall health for COPD patients with CT-confirmed muscle loss after a hospitalization.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07059637

• Prehab and Creatine/Whey Supplements in Cirrhosis-Related Frailty

  This study tests whether a digital prehabilitation app plus creatine and whey protein can help maintain muscle health in people with cirrhosis and frailty.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07029243

• High-protein, plant-dominant diet for people with liver cirrhosis

  This 6-month test compares a high-protein, mostly plant-based diet to a usual low-fat animal-protein diet in adults with decompensated cirrhosis who are awaiting kidney transplant to see which better preserves nutrition and muscle.

  Recruiting at 2 sites Agricultural University of Athens · Athens, Attica and 1 other locations · NCT07028580

• Frailty and sarcopenia in fibrosing ILDs: what it means for prognosis and care

  This study tests how frailty and muscle loss together affect outcomes in people aged 65 and older with fibrosing interstitial lung diseases who are treated in outpatient settings.

  Recruiting Nantes University Hospital · Nantes, Nantes · NCT07004595

• Effects of leucine and fatty acids on muscle health in older adults

  This study is testing if adding leucine-rich protein and healthy fats to the diets of older adults can help improve their muscle health and strength.

  Recruiting Chang Gung Memorial Hospital · Linkou District · NCT06991855

• Blood Flow Restriction Walking for stroke-related sarcopenia

  This study tests whether walking with blood flow restriction helps improve muscle strength and physical function in people who had a chronic stroke and have sarcopenia.

  Recruiting The Hong Kong Polytechnic University · Hung Hom, Kowloon and 1 other locations · NCT06974461

• High-definition surface electromyography to diagnose and monitor sarcopenia

  This project will try high-definition surface electromyography (HD-sEMG) to see if it can diagnose and monitor sarcopenia in people aged 75 and older who score ≥4 on the SARC-F screening questionnaire.

  Recruiting at 10 sites Assistance Publique - Hôpitaux de Paris · Issy-les-Moulineaux and 10 other locations · NCT06963359

• Examining the link between diabetic neuropathy and muscle mass in type 2 diabetes patients

  This study looks at how diabetic nerve damage affects muscle mass and strength in people over 45 with type 2 diabetes.

  Recruiting at 2 sites Ain Shams University · Cairo, Abbassia and 1 other locations · NCT06958302

• Silkworm pupa powder for improving Alzheimer's disease symptoms

  This study is testing if silkworm pupa powder can help improve symptoms and daily living for people with Alzheimer's disease.

  Recruiting Zhejiang Provincial Tongde Hospital · Hangzhou, Zhejiang · NCT06898476

• Muscle loss in pregnant women with gestational diabetes.

  This project will test whether pregnant women with gestational diabetes show signs of muscle loss (sarcopenia) and whether those muscle measures relate to pregnancy outcomes and thinking skills.

  Recruiting at 2 sites Istituto di Neuroscienze Consiglio Nazionale delle Ricerche · Vienna and 2 other locations · NCT06876090

• Movement-speed biofeedback to improve muscle activation and self-perception in older adults with sarcopenia

  This test will see if giving older adults with sarcopenia feedback on how fast they move during leg-press exercises helps preserve movement speed, increase muscle activation, and change motivation and perceived effort.

  Recruiting Creighton University · Omaha, Nebraska · NCT06853275

• Examining how muscle loss affects disease progression

  This study is trying to see how muscle loss affects the health and recovery of patients with liver cirrhosis, cancer, and those on breathing machines.

  Recruiting Universitatsmedizin Mainz - 1. Medizinische Klinik · Mainz, Rhineland-Palatinate · NCT06829290

• Tai Chi for Older Adults with Cognitive Concerns

  This study tests if an 8-week Tai Chi program can help older adults with mild cognitive impairment and muscle loss improve their thinking skills and overall well-being.

  Recruiting Ohio University · Athens, Ohio · NCT06828926

• Using ultrasound to measure muscle mass in older women with gynecologic cancer to predict hospital stay length

  This study is testing if using ultrasound to measure muscle mass in older women with gynecologic cancer can help predict how long they will stay in the hospital after surgery.

  Recruiting Tata Medical Center · Kolkata, West Bengal · NCT06816836

• How TIPS may improve muscle loss in cirrhosis and the role of FGF21

  This project tests whether TIPS helps people with cirrhosis regain muscle and whether blood FGF21 levels explain that improvement.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan · NCT06794853

• Evaluating muscle loss in menopausal women with and without hormone therapy

  This study is trying to see if hormone therapy helps menopausal women keep their muscle strength and mass compared to those who don’t use it and to pre-menopausal women.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06792201

• New treatment approach for age-related muscle loss

  This study is testing a new treatment that aims to help older adults with muscle loss by boosting a protein that encourages muscle growth, comparing their muscle health to that of younger people.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan, Europe · NCT06736249

• Prehabilitation program for patients with head and neck cancer

  This study is testing a prehabilitation program that includes exercise and nutrition support for people with head and neck cancer to see if it helps them feel better before surgery.

  Recruiting at 2 sites University of California, Davis · Sacramento, California and 1 other locations · NCT06722508

• Vitamin D maintenance plan after major surgery

  This trial will see if taking a monthly vitamin D dose instead of the usual maintenance schedule helps keep vitamin D levels and supports muscle recovery in adults (21–65) after major surgery.

  Recruiting Phase 3 Sengkang General Hospital · Singapore, Singapore · NCT06708741

• Cognitive effects of stomach or esophagus cancer surgery

  This study will see how often people who have surgery for stomach or esophagus cancer develop postoperative delirium and whether it is linked to preoperative depression, frailty, malnutrition, sarcopenia, or lower quality of life.

  Recruiting Karolinska Institutet · Huddinge · NCT06687291

• Biobanking study for sarcopenia in Austria

  This study is trying to collect health information and samples from people with liver cirrhosis and chronic inflammatory bowel disease in Austria to better understand and research sarcopenia.

  Recruiting Medical University of Graz · Graz · NCT06632743

• Resveratrol with strength training for older adults

  This program will test whether taking a daily resveratrol pill helps people aged 60+ gain more muscle and strength and improve blood vessel and brain health when they follow supervised strength training.

  Recruiting Texas Tech University · Lubbock, Texas · NCT06585865

• How nutrition and body composition relate to outcomes in people with IBD

  This study will see if nutrition and muscle mass affect outcomes in people with Crohn's disease or ulcerative colitis who are starting advanced medicines or having IBD-related surgery.

  Recruiting Barts & The London NHS Trust · London · NCT06550310

• Effects of different exercise types on gut health in older adults

  This study is testing whether different types of exercise, like strength training and aerobic workouts, can improve gut health and muscle strength in older adults with muscle loss.

  Recruiting Faculty of Sports- Research Center in Physical Activity, Health and Leisure · Porto · NCT06545123

• Combining Idecalcitol, Whey Protein, and Exercise to Treat Sarcopenia

  This study is testing whether combining a vitamin, whey protein, and exercise can help people with sarcopenia build muscle and improve their strength.

  Recruiting at 5 sites Phase 4 Zhejiang Provincial People's Hospital · Hangzhou, Zhejiang and 4 other locations · NCT06537115

• Evaluating muscle loss in liver cancer patients using blood tests and imaging

  This study is testing if blood tests and imaging can help doctors better understand muscle loss in patients with liver cancer.

  Recruiting CHU de Reims · Reims · NCT06475118

• Exploring the connection between diet-related muscle loss and obesity in patients with type 2 diabetes

  This study looks at how certain harmful substances in food might cause muscle loss in people with obesity and type 2 diabetes to see if it affects their overall health.

  Recruiting Azienda Ospedaliero Universitaria Maggiore della Carita · Novara · NCT06438900

• Digital diagnosis and treatment system for sarcopenia

  This study is testing a new digital system to help diagnose and treat sarcopenia in people aged 45 and older by providing early screening, medication, and rehabilitation programs tailored to their needs.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06380777

• Understanding the human metagenome's role in metabolic diseases

  This study is trying to see how the bacteria and substances in our bodies relate to health and conditions like obesity and muscle loss by looking at samples from different people.

  Recruiting Sengkang General Hospital · Singapore · NCT06363253

• Using linoleic acid-rich oil to improve muscle strength in older adults

  This study is testing if taking a daily dose of linoleic acid-rich oil can help older adults with muscle weakness feel stronger and move better.

  Recruiting Ohio State University · Columbus, Ohio · NCT06361511

• Assessing muscle mass and strength in patients with cirrhosis

  This study is testing how muscle mass and strength change in people with cirrhosis to see how it affects their daily lives and health.

  Recruiting University Hospital, Antwerp · Edegem, Antwerpen · NCT06345547

• Impact of resistance training on older patients with diabetes and muscle loss

  This study tests if a 12-week program of resistance training can help older people with type 2 diabetes and muscle loss improve their muscle strength and function.

  Recruiting National Geriatric Hospital · Hanoi · NCT06337357

• Using Ketosteril to Improve Muscle Loss in Kidney Disease Patients

  This study is testing if adding Ketosteril to a low-protein diet can help people with chronic kidney disease build muscle and improve strength without harming their kidneys.

  Recruiting Phase 3 Huashan Hospital · Shanghai · NCT06329622

• Assessing muscle loss in lung cancer patients using imaging techniques

  This study is testing a new way to use ultrasound and scans to find muscle loss in lung cancer patients to see if catching it early can help improve their treatment and recovery.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT06327594

• How frailty and chronic conditions influence each other and change over time

  This project will re-examine adults with frailty, muscle loss, or mild cognitive problems to try to see if frailty predicts how chronic diseases progress and which blood or imaging markers change.

  Recruiting IRCCS San Raffaele · Milan · NCT06324149

• Understanding muscle loss in patients with inflammatory bowel disease

  This study looks at how muscle loss affects people with severe flare-ups of inflammatory bowel disease, comparing those who get medical treatment to those who have surgery, to see how their muscle health changes over a year.

  Recruiting Sahlgrenska University Hospital · Gothenburg · NCT06300541

• Investigating how krill oil affects muscle strength in older adults

  This study is testing whether taking krill oil can help healthy older adults improve their muscle strength and function compared to those taking vegetable oil.

  Recruiting University of Glasgow · Glasgow · NCT06296875

• Understanding muscle loss in patients with chronic lung diseases

  This study looks at how muscle loss affects people with chronic lung diseases like COPD and ILD to see how common it is and how it relates to their overall health.

  Recruiting Taichung Veterans General Hospital · Taichung · NCT06280443

• Impact of muscle loss on chemotherapy side effects in cancer patients

  This study is testing how muscle loss affects the side effects of chemotherapy in cancer patients to see if it makes treatment harder to handle.

  Recruiting Centre Hospitalier Metropole Savoie · Chambéry · NCT06274268

• Using ultrasound and AI to diagnose sarcopenia in older adults

  This study is testing if using ultrasound and artificial intelligence can help doctors better diagnose muscle loss in older adults to improve their health and quality of life.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT06199856

• Using CytoSorb device for patients with acute on chronic liver failure

  This study tests if using the CytoSorb device can help lower bilirubin and ammonia levels and improve muscle strength in patients with severe liver failure.

  Recruiting University Hospital, Antwerp · Edegem, Antwerp · NCT06079021

• Using omega-3 fatty acids and nutrition to support cancer patients with muscle loss

  This study is testing if omega-3 supplements can help cancer patients with muscle loss feel stronger and better during their treatment.

  Recruiting Maimónides Biomedical Research Institute of Córdoba · Córdoba, Cordoba · NCT06015971

• Effect of nandrolone and therapy on sarcopenia in older adults

  This study is testing if a combination of nandrolone and therapy can help older adults with sarcopenia gain muscle strength and mass.

  Recruiting Phase 2 National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland · Warsaw, Masovian Voivodeship · NCT05978206

• Evaluating dietary supplements and exercise for patients with sarcopenia and lung disease

  This study is testing whether a combination of dietary supplements and supervised exercise can help people with sarcopenia and lung diseases like COPD and ILD improve their physical performance and lung function.

  Recruiting Orient Europharma Co., Ltd. · Taichung · NCT05926713

• Investigating protein changes in aging and muscle function

  This study is trying to see how changes in muscle proteins affect strength and movement in older adults to help improve their recovery and mobility.

  Recruiting University of Oregon · Eugene, Oregon · NCT05926219

• Essential amino acid supplements plus resistance exercise to improve muscle function in people on hemodialysis

  This project will test whether taking essential amino acid supplements together with a 12-week resistance exercise program can increase muscle size and handgrip strength in people on hemodialysis who have sarcopenia.

  Recruiting Chungnam National University Hospital · Daejeon, South Korea · NCT05884138

• Evaluating calf circumference for diagnosing sarcopenia in elderly hospitalized patients

  This study is testing if measuring calf size can help doctors diagnose sarcopenia in hospitalized patients aged 75 and older, instead of using the more complicated X-ray method.

  Recruiting Centre Hospitalier Régional d'Orléans · Orléans · NCT05869487

• JUMP — How common sarcopenia and 'chemobrain' are after cancer

  This project will see how common muscle loss (sarcopenia) and thinking problems ('chemobrain') are in adults who have finished cancer treatment.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT05800535

• Investigating dizziness and muscle weakness in older colorectal cancer patients during chemotherapy

  This study is testing whether a special exercise program and health check-ups can help older colorectal cancer patients feel less dizzy and improve their balance during chemotherapy.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen and 1 other locations · NCT05710809

• How different doses of 'Super-whey' affect muscle building in older adults

  This tests whether different doses of a leucine-rich 'Super-whey' protein help older adults increase muscle protein synthesis after resistance exercise.

  Recruiting University of Nottingham · Derby · NCT05700058

• Assessing muscle loss and liver health in patients with advanced liver disease

  This study is testing how muscle loss affects liver health in people with advanced liver disease by looking at their body composition and overall well-being over two years.

  Recruiting at 3 sites Linkoeping University · Eksjö and 2 other locations · NCT05502198

• Improving recovery in older colorectal cancer patients with sarcopenia

  This study is testing if exercise and nutrition can help older colon cancer patients with muscle loss recover better and have fewer infections after surgery.

  Recruiting Hospital Universitari de Bellvitge · L'Hospitalet de Llobregat, Barcelona · NCT05491434

• Exploring muscle composition's impact on liver transplant outcomes

  This study is testing how muscle health affects the success of liver transplants in patients with severe liver disease.

  Recruiting Mayo Clinic · Phoenix, Arizona · NCT05477277

• Electroacupuncture therapy for improving walking ability in elderly patients with sarcopenia

  This study is testing if adding electroacupuncture to rehabilitation training can help older adults with sarcopenia walk better and improve their muscle strength.

  Recruiting The Third Affiliated hospital of Zhejiang Chinese Medical University · Hangzhou, Zhejiang · NCT05431010

• Understanding muscle loss in chronic kidney disease patients

  This study looks at how chronic kidney disease affects muscle loss in patients, especially those with low kidney function or on dialysis, to better understand this serious issue.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT05353660

• Supporting immune and mitochondrial health in older adults with targeted nutrition

  This trial will test whether a personalized supplement containing branched-chain amino acids, micronutrients, and omega-3s helps older adults with malnutrition and sarcopenia improve muscle, immune, and mitochondrial function.

  Recruiting Centre Hospitalier Universitaire Vaudois · Lausanne, Switzerland · NCT05324475

• Exploring exercise and molecular factors in cancer-related muscle loss

  This study tests whether exercise can help people with non-small cell lung cancer who are losing muscle mass feel better and improve their quality of life.

  Recruiting University of Copenhagen · Copenhagen, DK · NCT05307367

• Exploring the links between sleep hygiene, muscle loss, and brain function in lung disease

  This study looks at how good or bad sleep affects muscle loss and brain function in people with lung diseases like COPD and IPF.

  Recruiting National Hospital Organization Minami Kyoto Hospital · Jōyō, Kyoto · NCT05193136

• Understanding muscle loss in heart failure patients

  This study looks at how factors like lifestyle and nutrition affect muscle loss in people with heart failure compared to healthy individuals.

  Recruiting Aarhus University Hospital · Aarhus N · NCT05063955

• Using high-definition electromyography to diagnose sarcopenia in older adults

  This study is testing a new way to diagnose muscle loss in older adults using a special technology to see if it can help identify those who may have sarcopenia.

  Recruiting at 5 sites Assistance Publique - Hôpitaux de Paris · Ivry-sur-Seine and 5 other locations · NCT04987814

• Assessing sarcopenia and nutrition in patients with tracheostomy during rehabilitation

  This study is trying to see how muscle strength and nutrition affect the time it takes for patients with a tracheostomy to breathe without the tube during their rehabilitation.

  Recruiting Fondazione Don Carlo Gnocchi ETS · Florence, Italy · NCT04791540

• Identifying factors to improve frailty in critically ill patients

  This study looks at critically ill patients to see if certain factors can help improve their frailty and recovery by tracking muscle loss and health over time.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT04717869

• Examining the effects of low muscle mass on chemotherapy toxicity in older adults with colorectal cancer

  This study looks at how having low muscle mass affects the side effects of chemotherapy in older adults with advanced colorectal cancer to see if it impacts their survival.

  Recruiting at 134 sites Wake Forest University Health Sciences · Millville, Delaware and 146 other locations · NCT03998202

• Investigating nutritional and environmental factors in elderly health

  This study is trying to find out how nutrition and the environment affect the health of older people living in Nanshan to help prevent diseases like high blood pressure and diabetes.

  Recruiting Sun Yat-sen University · Shenzhen, Guangdong and 1 other locations · NCT03569735

• Investigating the gut microbiome's role in muscle loss in liver cirrhosis patients

  This study is testing how changes in gut bacteria affect muscle loss in people with liver cirrhosis and whether improving nutrition can help.

  Recruiting Medical University of Graz · Graz · NCT03080129

• Pulmonary rehabilitation for patients with advanced lung cancer

  This study is testing whether a special exercise program can help people with advanced lung cancer breathe better, feel stronger, and improve their quality of life.

  Recruiting Instituto Nacional de Cancerologia de Mexico · Mexico City, Mexico City · NCT02978521

• Evaluating body composition's impact on chemotherapy toxicity in lung cancer patients

  This study is testing how body composition affects the side effects of chemotherapy in patients with advanced lung cancer to help improve their treatment experience.

  Recruiting Instituto Nacional de Cancerologia de Mexico · Mexico City · NCT02734069

NIH-funded research (30)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis

  This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11644470

• MiRNA roles in age-related muscle loss and NMJ health

  This project explores how small RNA molecules called miRNAs influence muscle aging and the neuromuscular junction in adults.

  NIH research University of Nebraska Lincoln · Lincoln, United States · NIH-11452282

• Multiscale microgels delivering GDNF and agrin to help with sarcopenia

  Aimed at older adults with muscle loss, this project tests a new treatment that slowly releases biological factors to support nerve-muscle connections and improve strength when combined with or for people who can’t do intense resistance training.

  NIH research University of Kentucky · Lexington, United States · NIH-11451992

• Frailty and sarcopenia in aging adults

  Aging adults, especially women, may develop frailty and muscle loss, and this project explores how muscle blood flow and inflammation relate to these conditions and to dementia and heart problems.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11411368

• High-field MRI to detect muscle changes in age-related muscle loss

  Very strong MRI scans will measure muscle quality, fat, and chemistry in older adults with sarcopenia.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11388325

• LA-rich oil to help strong muscles as we age

  A study will test whether adding a linoleic acid–rich oil to the diet improves muscle strength and walking ability in older adults with sarcopenia.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11372304

• Dendrimer-delivered therapy to slow age-related muscle loss

  This project uses a targeted drug delivery to protect muscles and nerve connections in older adults with age-related muscle loss.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11372120

• GLP-1 drugs and muscle health in older adults

  This study looks at how GLP-1 receptor agonists used by older adults might affect muscle mass, strength, and function over six months.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11288766

• Bone and muscle changes seen on chest CT in people with COPD

  Using chest CT scans and AI, researchers will look for patterns of bone loss and muscle weakness linked to COPD in people with and without the disease.

  NIH research University of Iowa · Iowa City, United States · NIH-11261204

• Muscle loss in men with prostate cancer on hormone therapy

  This project will follow men starting androgen deprivation (hormone) therapy for prostate cancer to track muscle loss, strength, and quality of life over 12 months.

  NIH research Seattle Inst for Biomedical/clinical Res · Seattle, United States · NIH-11258962

• Brainstem autonomic centers and their control of nerves to muscles in age-related muscle loss

  This research looks at whether changes in brain autonomic centers and the sympathetic nerves that talk to muscles contribute to muscle loss and weakness in older adults.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11251637

• Analyzing 3D body shapes to predict sarcopenia and obesity in older adults

  This study is looking at how 3D body scans can help spot muscle loss and obesity in older adults, making it easier and cheaper to keep track of health changes as we age, so we can catch problems early and take action to stay strong and active.

  NIH research George Washington University · Washington, United States · NIH-11170842

• Investigating how ULK2 helps prevent muscle loss as we age

  This study is looking at how a protein called ULK2 helps get rid of damaged proteins in muscles, which could lead to new ways to keep older adults strong and healthy as they age and fight off muscle loss.

  NIH research University of Iowa · Iowa City, United States · NIH-11170823

• Boosting Muscle Health by Supporting Cell Energy

  This project explores whether a special oil in the diet can help older adults with muscle weakness improve their strength and movement.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11126078

• Ultra-high-field MRI to see muscle changes in age-related muscle loss

  Using very detailed MRI and spectroscopy, this project looks at muscle structure and fat in older adults with sarcopenia and links those images to strength and walking speed.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11118933

• Investigating how to improve muscle strength and energy in aging individuals

  This study is looking at how a specific treatment might help older adults keep their muscles strong and healthy, so they can stay active and independent as they age.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11105773

• A system to monitor muscle strength and prevent decline in older adults

  This study is testing a new exercise band that connects to your phone to help older adults keep their muscles strong and stay independent by tracking their workouts and giving helpful feedback.

  NIH research Synchrohealth LLC · Lyme, United States · NIH-11099531

• Understanding muscle loss and recovery in older adults

  This study looks at how getting older makes it harder for people to bounce back and regain muscle strength after being inactive, like after an injury or being in bed, and it aims to find ways to help older adults recover their muscle and stay active and independent.

  NIH research Oklahoma City VA Medical Center · Oklahoma City, United States · NIH-11098430

• Investigating the role of lipid hydroperoxides in muscle loss and weakness in older adults

  This study is looking at how certain harmful substances in the body might cause muscle loss and weakness in older adults, and it’s testing a treatment that could help improve muscle health and strength as we age.

  NIH research Oklahoma City VA Medical Center · Oklahoma City, United States · NIH-11098418

• Understanding bone and muscle changes in COPD patients

  This study is looking at how weak bones and muscles affect people with COPD by using special imaging and technology, and it aims to help doctors better understand and treat these issues in patients like you.

  NIH research University of Iowa · Iowa City, United States · NIH-11055630

• Understanding how aging affects muscle health and function

  This study is looking at how the nerves that control our body's automatic functions affect muscle health as we get older, and it aims to find ways to help older adults keep their muscles strong and healthy.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11017759

• Understanding muscle loss in men with prostate cancer receiving hormone therapy

  This study is looking at how losing muscle mass and strength affects men with advanced prostate cancer who are receiving hormone therapy, and it aims to find ways to better support these patients over the next year.

  NIH research Seattle Inst for Biomedical/clinical Res · Seattle, United States · NIH-11010810

• Using stem cells to treat muscle loss in older adults

  This study is looking at how special stem cells can be used to help rebuild muscle in older adults who are losing muscle strength due to aging, and it’s testing a new treatment to see if it can make these stem cells work better for muscle repair.

  NIH research University of South Florida · Tampa, United States · NIH-11004990

• Understanding muscle loss in early Alzheimer's disease

  This study is looking at how early Alzheimer's disease can cause muscle loss before memory problems start, and it aims to find ways to keep your muscles healthy and strong while managing the condition.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-10991329

• Investigating muscle changes in elderly patients with sarcopenia using advanced imaging techniques

  This study is looking at how we can use advanced MRI technology to take a closer look at muscle health in older adults with sarcopenia, helping us understand how changes in muscle structure relate to everyday activities like grip strength and walking speed, which could lead to better ways to treat this condition.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10904781

• A remote monitoring system for muscle health and strength in older adults

  This study is testing a new device called BandPass that helps older adults keep track of their strength exercises at home, making it easier for them to stay healthy and independent as they age.

  NIH research Synchrohealth LLC · Lyme, United States · NIH-10877887

• How exercise and diet affect muscle loss in older adults with HIV

  This study is looking at how staying active and eating well can help prevent muscle loss in older adults living with HIV, and it aims to find ways to keep your muscles strong as you age.

  NIH research University of Washington · Seattle, United States · NIH-10821495

• Using ultrasound technology to assess muscle health in breast cancer patients

  This study is testing a new way to check muscle health in breast cancer patients using a combination of ultrasound and electrical signals, making it easier and more accurate to understand how treatment might affect your muscles.

  NIH research Rytek Medical, INC. · Lebanon, United States · NIH-10760707

• Assessing muscle health in older adults using electrical signals

  This study is looking at a new, quick way to check the muscle health of older adults to help spot sarcopenia, which is when people lose muscle strength as they age, using a safe technique that sends small electrical currents through the muscles, so we can better support seniors in staying strong and independent.

  NIH research Myolex, INC. · Brookline, UNITED STATES · NIH-10668482

• Understanding how intermuscular fat affects muscle health and diabetes

  This study is looking at how a specific type of fat in our muscles might affect muscle strength and how our bodies use insulin, which could help find new ways to treat muscle loss and type 2 diabetes, and it may involve patients providing tissue samples or taking part in related tests.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10448489

Related topics

Quick answers

How many Sarcopenia clinical trials are recruiting right now?

125, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 31 countries. The most sites are in China (20 trials), United States (16 trials), Turkey (Türkiye) (12 trials), Taiwan (11 trials), France (8 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 3: 2, Phase 4: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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