Using Multimodal Ultrasound to Check Muscle Mass in Metabolic Disease Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will use advanced ultrasound methods that combine B-mode imaging, shear-wave elastography, and microvascular imaging, plus AI analysis, to measure muscle size, stiffness, and fat infiltration in adults with metabolic diseases. The study will compare ultrasound findings with clinical and biochemical data and assess measurement reliability across two sonographers. Data will be analyzed to identify diagnostic thresholds and potential links between muscle metrics and metabolic control. Participation includes imaging, blood tests, physical function tests, and follow-up assessments at Zhangzhou Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of metabolic syndrome according to the Chinese Consensus on Diagnosis and Management of Metabolic Syndrome (2020 edition), meeting at least 3 of the following 5 criteria: abdominal obesity, hypertension, hyperglycemia, hypertriglyceridemia, and low HDL-C.
* Diagnosis of type 2 diabetes according to the ADA 2023 diagnostic criteria, with disease duration of at least 1 year.
* Body mass index (BMI) \>= 28 kg/m², without hypertension, hyperglycemia, dyslipidemia, or other metabolic abnormalities.
* Healthy volunteers without metabolic diseases, muscle diseases, chronic liver or kidney dysfunction, malignancies, cardiovascular diseases, or neurological disorders, and without long-term use of corticosteroids or other medications affecting muscle metabolism.
* Age and sex matched across all four groups.
* Willing and able to provide written informed consent and comply with all study procedures including ultrasound examination, DXA scan, and follow-up visits.

Exclusion Criteria:

* Severe hepatic or renal failure, malignancy, stroke, severe cardiovascular disease, or autoimmune diseases.
* Long-term use of corticosteroids, muscle relaxants, or other medications affecting muscle metabolism.
* Presence of movement disorders, joint diseases, muscle injury, muscular dystrophy, or other conditions affecting muscle function.
* Pregnancy or lactation.
* Inability to cooperate with ultrasound examination, DXA scanning, or follow-up assessments.
* Any other condition that, in the opinion of the investigator, would interfere with the study objectives or participant safety.

Where it's running

• Zhangzhou Hospital, Fujian Medical University
  Zhangzhou, Fujian, China Recruiting

Study contacts

• Principal investigator: Wenting Jiang, Master's — Department of Ultrasound Medicine, Zhangzhou Hospital Affiliated to Fujian Medical University, China
• Study coordinator: Fahui Lu, Master's
• Email: 18750745115@163.com
• Phone: 0596-2082027

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Investigating body fat distribution and its impact on metabolic diseases in Japanese adults

  This study looks at how the way body fat is distributed affects the risk of metabolic and heart diseases in Japanese adults.

  Recruiting Osaka Metropolitan University · Sakai, Osaka · NCT06694012

• Understanding the human metagenome's role in metabolic diseases

  This study is trying to see how the bacteria and substances in our bodies relate to health and conditions like obesity and muscle loss by looking at samples from different people.

  Recruiting Sengkang General Hospital · Singapore · NCT06363253

• Screening patients at risk for liver disease in Europe

  This study is trying to find out if screening high-risk patients in Europe for liver disease using simple tests can help doctors identify and better understand conditions like metabolic dysfunction-associated steatotic liver disease.

  Recruiting at 6 sites Julius Clinical · Brussels, Vlaams-brabant and 12 other locations · NCT05651724

• Investigating nutritional and environmental factors in elderly health

  This study is trying to find out how nutrition and the environment affect the health of older people living in Nanshan to help prevent diseases like high blood pressure and diabetes.

  Recruiting Sun Yat-sen University · Shenzhen, Guangdong and 1 other locations · NCT03569735

• Switching to Zenagamtide From Tirzepatide in Adults With Overweight or Obesity With or Without Type 2 Diabetes

  This study tests whether adults who are overweight or have obesity (with or without type 2 diabetes) can switch from tirzepatide to a new treatment called zenagamtide to find a tolerable dose.

  Recruiting at 2 sites Phase 1 Novo Nordisk A/S · Glendale, California and 1 other locations · NCT07868354

• GLP-1 receptor agonist use and muscle health in adults with obesity without diabetes

  This study tests whether GLP-1 receptor agonists affect muscle mass and strength in adults with obesity who don’t have diabetes.

  Recruiting Istanbul Saglik Bilimleri University · Istanbul, Kucukcekmece · NCT07858864

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.