Essential amino acid supplements plus resistance exercise to improve muscle function in people on hemodialysis
Official title: A Randomized Controlled Trial to Analyze the Effects of Essential Aminoacid Supplementation and Exercise on the Improvement of Skeletal Muscle Function in Hemodialysis Patients
Run by Chungnam National University Hospital · NCT05884138 · Data updated 2026-11-12
This project will test whether taking essential amino acid supplements together with a 12-week resistance exercise program can increase muscle size and handgrip strength in people on hemodialysis who have sarcopenia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 80 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Chungnam National University Hospital Academic / other |
| Locations | 1 site (Daejeon, South Korea) |
| Status | Recruiting |
| Started | August 28, 2023 |
| Main results expected | December 31, 2024 |
| Study ends | August 23, 2026 |
| Registry record updated | March 18, 2026 |
| Trial ID | NCT05884138 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults on maintenance hemodialysis who were diagnosed with sarcopenia or frailty in the prior cohort, live in the community, and can walk at least 100 meters with or without an aid are ideal candidates.
✕Probably not a fit
Patients with active cancer, significant psychiatric illness, recent acute bacterial infection, pregnancy, major small intestine or colon resection, or those who are wheelchair-bound and unable to walk 100 meters are excluded and unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, 1:1 randomized controlled trial enrolling 40 hemodialysis patients previously diagnosed with sarcopenia or frailty. Participants will receive a combined intervention of supervised resistance exercise and essential amino acid nutritional supplementation for 12 weeks, with outcomes measured at baseline and at 4, 8, and 12 weeks. The primary outcomes are change in muscle mass and handgrip strength at 12 weeks, and the analysis will follow the intention-to-treat principle. Functional measures and adverse events will also be recorded throughout the intervention period.
Why it matters
Potential benefit: If successful, the combined exercise and amino acid supplement program could increase muscle mass and strength, improving mobility and daily function for people on hemodialysis with sarcopenia.
How similar studies have gone: The investigators reported a 2021 pilot suggesting benefit, and prior trials in older adults and some dialysis cohorts have shown that combined resistance exercise and protein/amino acid supplements can improve muscle mass and strength, but large randomized trials in hemodialysis patients are still limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with hemodialysis * Community-dwellers * Able to walk with or without assistive devices for more than 100 meters Exclusion Criteria: * A person with cancer disease. * People with psychiatric symptoms. * A person who has an absorption disorder or has a history of resection of the small intestine or colon * Pregnant women * A person treated for acute bacterial infections * A person who is in a wheelchair due to inconvenience in walking.
Where it's running
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Chungnam National University Hospital
Daejeon, South Korea, South Korea Recruiting
Study contacts
- Study coordinator: Hyon-Seung Yi
- Email: jmpbooks00@gmail.com
- Phone: 82-10-2411-9766
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.