Multimodal exercise program for middle-aged and older adults with diabetic sarcopenia
Official title: Effects of Multimodal Training on Muscle Function and Glucose Metabolism in Middle-Aged and Older Adults With Type 2 Diabetes Mellitus and Sarcopenia
Run by Chung Shan Medical University · NCT07398495 · Data updated 2026-11-12
This program will try a 12-week multimodal exercise plan with supervised, home-based, and digital support to improve muscle function and metabolic health in people aged 45–85 who have type 2 diabetes and sarcopenia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 45 Years to 85 Years |
| Sex | All |
| Enrollment | 128 (estimated) |
| Sponsor | Chung Shan Medical University Academic / other |
| Locations | 1 site (Taichung, Taiwan) |
| Status | Recruiting |
| Started | February 23, 2026 |
| Main results expected | May 15, 2026 |
| Study ends | August 15, 2026 |
| Registry record updated | March 30, 2026 |
| Trial ID | NCT07398495 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 45–85 with diagnosed type 2 diabetes and sarcopenia who are on a stable regimen of oral hypoglycemic agents and can communicate in Mandarin or Taiwanese and attend supervised sessions are ideal candidates.
✕Probably not a fit
Patients with severe comorbidities such as end-stage renal disease, active diabetic foot ulcers, recent stroke, major limb limitations that prevent exercise, severe cognitive impairment, or uncontrolled psychiatric illness are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial will enroll 128 adults with type 2 diabetes and sarcopenia and randomly assign them to a multimodal exercise intervention or a control group receiving standard health education. The 12-week intervention combines supervised training sessions, guided home exercises, and digital support plus educational materials. Outcomes including physical function, sarcopenia risk measures, metabolic control, and quality of life will be measured at baseline, week 12, and week 24. The trial is conducted at Chung Shan Medical University Hospital in Taichung, Taiwan and focuses on middle-aged and older Asian participants.
Why it matters
Potential benefit: If successful, the program could slow muscle loss, increase strength and physical function, and improve glycemic control and quality of life for people with T2DM and sarcopenia.
How similar studies have gone: Previous resistance and multimodal exercise programs have shown improvements in muscle mass, strength, and metabolic markers in older adults with sarcopenia and diabetes, though data specifically in Asian T2DM populations are more limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosed with both Type 2 Diabetes Mellitus (T2DM) and sarcopenia. * Maintained on a stable regimen of oral hypoglycemic agents. * Aged 45 years or older. * Capable of communicating effectively in Mandarin or Taiwanese. * Willing to provide informed consent or have it obtained from a legally authorized representative. Exclusion Criteria: * • Limited limb or joint function that prevents exercise (e.g., recent fractures or dislocations). * Communication barriers or severe emotional/psychological issues (e.g., uncontrolled depression or severe mental illness). * Severe cognitive impairment (e.g., dementia). * End-stage renal disease (ESRD). * Major comorbidities or complications, including active diabetic foot ulcers, amputation, recent myocardial infarction, severe autonomic neuropathy, or a history of stroke within the last 3 years.
Where it's running
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Chung Shan Medical University Hospital
Taichung, Taiwan, Taiwan Recruiting
Study contacts
- Study coordinator: yueh chu wu WU YUEH CHU
- Email: yueh.chu46240@gmail.com
- Phone: 886-952680613
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.