Ultrasound-measured thigh muscle thickness and sarcopenia markers in stroke patients
Official title: EVALUATION OF THE RELATIONSHIP BETWEEN ULTRASONOGRAPHICALLY MEASURED QUADRICEPS MUSCLE THICKNESS AND SARCOPENIA MARKERS (HANDGRIP STRENGTH, SARC-F) AND KINESIOPHOBIA IN STROKE PATIENTS
Run by Istanbul Physical Medicine Rehabilitation Training and Research Hospital · NCT07734506 · Data updated 2026-11-12
This study tests whether ultrasound measurements of thigh muscles relate to sarcopenia indicators and fear of movement in people with ischemic stroke.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 40 Years to 80 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Istanbul Physical Medicine Rehabilitation Training and Research Hospital Government |
| Locations | 1 site (Istanbul, Istanbul) |
| Status | Recruiting |
| Started | August 1, 2025 |
| Main results expected | August 1, 2026 |
| Study ends | August 1, 2026 |
| Registry record updated | July 29, 2026 |
| Trial ID | NCT07734506 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 40–80 with chronic ischemic stroke (6 months to 2 years since onset) and ambulatory capacity due to Brunnstrom lower-extremity stage ≥3.
✕Probably not a fit
Patients outside the specified stroke duration, those with hemorrhagic stroke, knee conditions, or other exclusion criteria may not benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This cross-sectional study will recruit 50 adults with ischemic stroke of 6 months to 2 years duration to examine how quadriceps thickness measured by ultrasonography relates to sarcopenia markers such as SARC-F scores and handgrip strength, and to levels of kinesiophobia. Measurements will assess bilateral quadriceps thickness (rectus femoris and vastus intermedius) and compare them with functional sarcopenia indicators. The research is conducted at the Istanbul Physical Medicine and Rehabilitation Training and Research Hospital between August 1, 2025, and August 1, 2026, without classification of sarcopenia status. The study explores whether ultrasound-based muscle size can reflect or align with conventional sarcopenia screening tools in the stroke population. No interventions are applied; this is an observational, cross-sectional analysis.
Why it matters
Potential benefit: If successful, ultrasound-based quadriceps measurements could help clinicians screen for sarcopenia risk and tailor rehabilitation in stroke patients.
How similar studies have gone: Similar assessments have shown relationships between muscle size and function in other populations, but data in stroke patients remain limited and exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Chronic stroke duration between 6 months and 2 years * Ischemic stroke type * Age between 40-80 years * Brunnstrom lower extremity motor stage ≥3, ambulatory * Provision of written informed consent Exclusion Criteria: * Hemorrhagic stroke * Stroke onset more than 2 years prior * Inflammatory arthritis or other rheumatologic disease * History of knee trauma * Pre-stroke neurological gait disorder * Recurrent stroke * Lower extremity amputation * Knee joint contracture
Where it's running
-
Istanbul Physical Medicine and Rehabilitation Training and Research Hospital
Istanbul, Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Alperen Kolukisaoğlu, Md — Istanbul Physical Medicine and Rehabilitation Training and Research Hospital
- Study coordinator: Alperen Kolukisaoğlu, Md
- Email: drkolukisaoglu@gmail.com
- Phone: +905387911854
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.