Investigating the gut microbiome's role in muscle loss in liver cirrhosis patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study explores the relationship between changes in the gut microbiome and sarcopenia in patients with liver cirrhosis. It aims to understand how alterations in the microbiome contribute to protein-energy malnutrition and muscle loss, which are common complications in these patients. The study will involve hospitalized patients diagnosed with cirrhosis and will assess the impact of nutritional interventions on the microbiome. By utilizing imaging techniques like CT or MRI, the severity of sarcopenia will be objectively measured.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Hospitalized patients for any reason with clinical/radiological/histological diagnosis of cirrhosis
* Age \>18y
* Informed consent
* CT/MRI scan within +/-14 days of the baseline study visit

Exclusion Criteria:

* Hepatic encephalopathy \> grade 2 and or other cognitive disorder not allowing informed consent
* advanced hepatocellular carcinoma
* Any other condition or circumstance, which, in the opinion of the investigator, would affect the patient's ability to participate in the protocol

Where it's running

• Medical University Graz
  Graz, Austria Recruiting

Study contacts

• Study coordinator: Vanessa Stadlbauer-Köllner, AssocProf Dr
• Email: vanessa.stadlbauer@medunigraz.at
• Phone: +4331638582282

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.