How different doses of 'Super-whey' affect muscle building in older adults
Assessing the Dose-response of Muscle Protein Synthesis to "Super-whey" at Rest and in Response to Acute Exercise in Older Adults
This tests whether different doses of a leucine-rich 'Super-whey' protein help older adults increase muscle protein synthesis after resistance exercise.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 65 Years to 85 Years |
| Sex | Male |
| Sponsor | University of Nottingham Academic / other |
| Locations | 1 site (Derby) |
| Trial ID | NCT05700058 on ClinicalTrials.gov |
What this trial studies
Older and young adult volunteers will receive varying doses of a leucine-rich 'Super-whey' protein supplement combined with resistance exercise to measure acute muscle protein synthesis responses. Participants are screened for cardiovascular, metabolic, neurological, clotting, and lactose-intolerance exclusions and must fall within a specified BMI range. Researchers will compare dose-related changes in muscle protein synthesis between age groups to define a dose-response relationship. The protocol uses laboratory-based measures and on-site visits at a single clinical research center.
Who should consider this trial
Good fit: Ideal candidates are adults aged 65+ (with a young adult comparator group aged 18–35) who can safely perform resistance exercise, have BMI between 18 and 35 kg/m2, and do not have major cardiovascular, metabolic, neurological, clotting conditions or lactose intolerance.
Not a fit: People with uncontrolled heart, lung, or metabolic disease, clotting or major neurological disorders, lactose intolerance, BMI <18 or >35, or those unable to perform resistance exercise are unlikely to be eligible or receive benefit.
Why it matters
Potential benefit: If successful, the results could identify the best protein dose to help older adults preserve or rebuild muscle and maintain independence.
How similar studies have performed: Previous trials with leucine-rich whey protein have shown increased muscle protein synthesis in older adults, but the optimal dosing and precise dose-response remain uncertain.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant is in the desired age-ranges (young adults: 18-35 years; older adults: 65+ years). * Participant is willing and able to give informed consent for participation in the study. * Participant is physically able to perform resistance exercise Exclusion Criteria: * A BMI \<18 or \>35 kg/m2 * Active cardiovascular, cerebrovascular or respiratory disease: e.g. uncontrolled hypertension (BP \> 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt, recent cardiac event, COPD, pulmonary hypertension or recent (6 mo) stroke * Any metabolic disease * Clotting dysfunction * A history of, or current neurological or musculoskeletal conditions (e.g. epilepsy) * Lactose intolerance * Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
Where this trial is running
Derby
- Centre of Ageing, Metabolism and Physiology — Derby, United Kingdom (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.