Exploring exercise and molecular factors in cancer-related muscle loss

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the loss of muscle mass associated with cancer, particularly focusing on cancer cachexia, which affects a significant number of patients with metastatic cancer. It aims to understand the molecular factors contributing to this condition and the role of exercise in mitigating muscle loss. Participants will engage in exercise training as part of the intervention, with the goal of improving physical function and quality of life. The study will include patients with non-small cell lung cancer who are not eligible for concurrent chemotherapy or radiation therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria, WP1+WP2X+WP2:

* Men and women at or above the age of 18
* Histological and radiological verified NSCLC (both squamous and adenocarcinoma) st. IIIb/IV stage not eligible to concurrent chemo/radiation therapy as primary treatment
* Referred for 1st line palliative anticancer therapy (platin based, immunotherapy, combined therapy or TKI), this goes for WP1 + WP2
* Referred for palliative anticancer therapy (platin based, immunotherapy, combined therapy or TKI), for recurrent cancer, this goes only for WP2X.
* Having a staging/baseline CT within 4 weeks of initiation of treatment (PET/CT are also allowed), or a baseline scan planned within the first week of treatment.
* ECOG Performance Status 0-2
* Having signed the informed consent form

Exclusion Criteria, WP1+WP2X+WP2:

* Any other known malignancy requiring active treatment (prior cancer diagnosis is not some exclusion criteria if oncology-treatment is completed)
* Local palliative radiotherapy as primary treatment
* ECOG Performance status \> 2
* Physical disabilities excluding physical testing
* Inability to understand Danish
* Inability to understand scoring systems/patient-reported outcome measures

Inclusion Criteria, WP3:

* Men and women above the age of 18
* Histological and radiological verified NSCLC (both squamous and adenocarcinoma) st. IIIb/IV stage
* ECOG Performance Status 0-2
* Having signed the informed consent form.

Exclusion Criteria, WP3:

* Any other known malignancy requiring active treatment (prior cancer diagnosis is not some exclusion criteria if oncology-treatment is completed)
* ECOG Performance Status \> 2
* Physical disabilities excluding physical testing
* Inability to understand Danish
* Inability to understand scoring systems/patient-reported outcome measures

Where it's running

• University of Copenhagen
  Copenhagen, Dk, Denmark Recruiting

Study contacts

• Principal investigator: Lykke Sylow, Ass.proff. — University of Copenhagen
• Study coordinator: Jonas Sørensen, MD.
• Email: jonas.soerensen@sund.ku.dk
• Phone: 0045-51513480

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.