Pulmonary rehabilitation for patients with advanced lung cancer
Effect of a Pulmonary Rehabilitation Program on Skeletal Muscle Mass, Pulmonary Function, Inflammatory Response and Overall Survival on Patients Diagnosed With Non-small-cell Advanced Cancer
This study is testing whether a special exercise program can help people with advanced lung cancer breathe better, feel stronger, and improve their quality of life.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 94 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Instituto Nacional de Cancerologia de Mexico Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Mexico City, Mexico City) |
| Trial ID | NCT02978521 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effects of a pulmonary rehabilitation program on patients with advanced non-small cell lung cancer. Participants will be randomized into an intervention group, receiving 12 sessions of pulmonary rehabilitation over 4-6 weeks, or a control group, receiving general recommendations for physical activity. The study will assess improvements in pulmonary function, muscle mass, exercise tolerance, inflammatory response, quality of life, and overall survival. Nutritional assessments and interventions will also be provided to both groups as needed.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with advanced non-small cell lung cancer who have a good performance status and are eligible for chemotherapy or tyrosine kinase inhibitors.
Not a fit: Patients with symptomatic brain metastasis, uncontrolled pain, or those who regularly engage in moderate to intense physical activity may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance the quality of life and survival outcomes for patients with advanced lung cancer.
How similar studies have performed: Previous studies have shown positive outcomes with pulmonary rehabilitation in lung cancer patients, suggesting this approach has potential benefits.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Confirmed diagnosis of advanced non-small-cell lung cancer * Good performance status (ECOG 0-1) * Life expectancy \>12 weeks * Eligible to receive treatment with chemotherapy or tyrosinkinase inhibitors * Recent electrocardiogram without evidence of arrythmia Exclusion Criteria: * Symptomatic brain metastasis * Uncontrolled pain (Visual Analog Scale \>5) * Uncontrolled hypertension (\>140/100mmHg) * Practice of regular moderate to intense physical activity at least 3 day/week * Not residents of Mexico City or unable to attend to therapy sessions
Where this trial is running
Mexico City, Mexico City
- Instituto Nacional de Cancerología — Mexico City, Mexico City, Mexico (Recruiting)
Study contacts
- Study coordinator: Oscar Arrieta
- Phone: 01 55 56280400
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.