GLP-1 receptor agonist use and muscle health in adults with obesity without diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, descriptive study follows non-diabetic adults with obesity who are starting a GLP-1 receptor agonist as part of routine care. Researchers measure muscle mass, strength, and physical performance at baseline and after three months, and relate these changes to weight loss. Assessments include SARC-F screening, handgrip strength, chair stand test, gait speed, and bioelectrical impedance analysis for body composition, using data from clinical records. No experimental treatment is assigned; the GLP-1 RA is prescribed by the treating physician. The goal is to understand how weight loss with GLP-1 RAs impacts sarcopenia risk and muscle health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Diagnosis of obesity (BMI \>30 kg/m²)
* Currently using a GLP-1 RA
* No hearing, speech or cognitive impairment
* Not receiving treatment for major depressive disorder and not using antidepressants
* Verbal consent to participate

Exclusion Criteria:

* Diagnosis of diabetes
* History of chronic kidney failure, chronic liver disease, decompensated heart failure or malignancy
* Pregnancy or breastfeeding
* Walking impairment
* Not meeting inclusion criteria or unwilling to participate

Where it's running

• Kanuni Sultan Süleyman Training and Research Hospital
  Istanbul, Kucukcekmece, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Gülden Anataca
• Email: ganataca@yahoo.com
• Phone: 05059284244

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.