Condition

Metabolic Diseases clinical trials and research

• 19Clinical trials
• 14NIH research projects
• 1New in 30 days
• 10Countries

Newest Metabolic Diseases clinical trials

All recruiting trials (19)

• Registering medical data and care outcomes for ALS, SMA, and other motor disorders

  This registry slowly collects routine-care information from adults with ALS, SMA, or other motor disorders to see how they’re treated and how care affects outcomes.

  Recruiting Ambulanzpartner Soziotechnologie APST GmbH · Berlin, State of Berlin · NCT07900672

• Myokines in metabolic and endocrine diseases linked to sarcopenia

  This study tests whether myokines can serve as biomarkers or drivers of sarcopenia and sarcopenic obesity in people with metabolic or endocrine diseases.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Woluwe-Saint-Pierre - Sint-Pieters-Woluwe · NCT07703683

• AMX0035 in adults with Type 1 Diabetes

  This study tests whether 24 weeks of the oral medication AMX0035 help improves metabolic health in adults with Type 1 Diabetes compared with a placebo.

  Recruiting Phase 2 University of Washington · Seattle, Washington and 1 other locations · NCT07699380

• A lifetime registry and imaging database for people with heart, kidney, and metabolic conditions

  This project will see if creating a long-term clinical and imaging database for adults with heart, kidney, or metabolic conditions can improve prediction of outcomes and guide care.

  Recruiting First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT07547098

• Early pregnancy lifestyle patterns and glucose changes in a TOFFFY sub-study

  This study tests whether daily patterns like sleep, activity, and meal timing in early pregnancy affect glucose levels and the risk of gestational diabetes, using CGM and wearable data in pregnant women in Singapore.

  Recruiting KK Women's and Children's Hospital · Singapore, Singapore · NCT07534670

• Measuring how well patients follow daily oral medicines in Necker’s inherited metabolic diseases department

  This project will measure how well children, adolescents, and young adults with inherited metabolic diseases at Necker follow their daily oral medicines to see if a medication-education workshop is needed.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07356557

• Gout, inflammation, and metabolic health in French Polynesia

  This project will collect blood, urine, and genetic information to see if specific genes and molecular markers explain gout, inflammation, and metabolic problems in adults with Polynesian ancestry in French Polynesia.

  Recruiting at 5 sites Lille Catholic University · Faa'a and 5 other locations · NCT07343336

• HIIT versus time-restricted eating to lower type 2 diabetes risk in adolescents and young adults

  This project will test whether 4 weeks of high-intensity interval training or time-restricted eating improves heart and metabolic health in adolescents and young adults with overweight or obesity.

  Recruiting Syracuse University · Syracuse, New York · NCT07215533

• SMILE: Tracking muscle loss, metabolic health, and aging over time

  This project will follow adults to see if combining clinical data, imaging, and blood/tissue samples can detect and track muscle loss and metabolic changes linked to aging.

  Recruiting RenJi Hospital · Shanghai · NCT07205510

• A dietary and behavioral intervention to improve health and sustainability

  This study is testing a new lifestyle program that combines diet tips and support to see if it can help people improve their health and the environment better than regular diet advice alone.

  Recruiting Chalmers University of Technology · Gothenburg · NCT06973408

• Evaluation of cardiometabolic factors in heart failure patients

  This study looks at how different health factors related to metabolism and body fat affect heart function and outcomes in people with heart failure.

  Recruiting Ruijin Hospital · Shanghai · NCT06939985

• Effects of a Low Valine Diet on Weight and Metabolism

  This study is testing if meal replacements with less valine can help overweight and obese people lose weight and improve their metabolism compared to regular meal replacements.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT06883578

• Using MRI to study brain differences in metabolic diseases

  This study is trying to see how brain differences in people with metabolic diseases compare to healthy individuals using MRI scans.

  Recruiting University of Ulm · Ulm · NCT06709846

• Evaluating human placental membrane products for treating nonhealing diabetic foot and venous leg ulcers

  This study is testing whether using human placental products along with regular care can help people with stubborn diabetic foot and leg ulcers heal better.

  Recruiting C5 Biomedical · Metairie, Louisiana · NCT06674980

• Exploring how metabolic profiles relate to chronic diseases and tumors

  This study looks at how metabolic health affects the risk of developing chronic diseases and tumors in adults to find common risk factors.

  Recruiting First Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06524037

• Nicotinamide Riboside and Exercise for Healthy Aging

  This study is testing if taking a supplement called nicotinamide riboside along with exercise can help older adults feel healthier and age better.

  Recruiting Finis Terrae University · Santiago, Santiago Metropolitan · NCT06425042

• Understanding genetic effects on response to oral semaglutide in type 2 diabetes

  This study is testing how different genes affect how well people with type 2 diabetes respond to the oral medication semaglutide.

  Recruiting Phase 4 Massachusetts General Hospital · Boston, Massachusetts · NCT06003153

• Daily beef intake's impact on zinc absorption and heart health

  This study is testing if eating beef every day can help people aged 55 to 70 absorb more zinc and improve their heart health compared to other protein sources.

  Recruiting University of California, Davis · Davis, California · NCT05236374

• Identifying genetic and metabolic diseases in children

  This study is trying to find new genetic causes of rare diseases in children by looking closely at their genes and metabolism.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT02650622

NIH-funded research (14)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Postnatal and Prenatal Base Editing Therapies for Metabolic Diseases

  This grant aims to advance genetic medicine that could one day treat metabolic diseases before or after birth using precise genome editing techniques.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11421631

• Postnatal and Prenatal Base Editing for Metabolic Diseases

  A large NIH grant is funding research to develop gene-editing methods that could treat metabolic diseases before and after birth.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11389343

• GLP-1 producing engineered probiotics to help manage metabolic diseases

  A research project aims to create probiotic bacteria that constantly deliver GLP-1 to help people with type 2 diabetes and obesity manage their condition.

  NIH research Medosome Biotec, LLC · Alachua, UNITED STATES · NIH-11314389

• Changing bile acids to help diabetes, fatty liver, and weight problems

  This project is developing medicines that shift bile acid balance in the liver to help adults with type 2 diabetes, fatty liver disease, or obesity.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11252541

• Precise gene editing before or after birth for metabolic diseases

  This project develops precise gene-editing treatments given before birth or soon after to correct genetic metabolic conditions in children.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11145243

• How a specific bacterium affects fat and metabolism

  This study is looking at a new type of bacteria called Clostridium immunis to see how it might help manage body fat and improve conditions like type 2 diabetes, which could lead to new treatment options for people dealing with these metabolic issues.

  NIH research Duke University · Durham, United States · NIH-11091384

• Understanding the links between heart, kidney, and metabolic diseases

  This study is looking at how obesity and diabetes can lead to heart and kidney problems, especially for people in Mississippi, and it aims to find new ways to help improve health for those dealing with these issues.

  NIH research University of Mississippi Med Ctr · Jackson, United States · NIH-11033656

• Training undergraduate students in diabetes and metabolic disease research

  This program is all about helping people with diabetes and metabolic disorders by giving college students hands-on research experience, so they can learn more about these health issues and contribute to finding better solutions.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11018313

• Using bile acids to improve treatment for metabolic diseases

  This study is looking at how bile acids can help treat obesity-related health issues like type 2 diabetes and fatty liver disease by blocking a specific enzyme, which could lead to new medications with fewer side effects for patients.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11013360

• New treatments for metabolic diseases in cystic fibrosis patients

  This study is looking at new medications that could help people with cystic fibrosis manage diabetes and liver issues by targeting specific glucose transporters, especially for those who have had worsening health after starting a treatment called Trikafta.

  NIH research Genetobe INC. · Ann Arbor, United States · NIH-11006091

• Training program for recent graduates in diabetes and metabolic diseases

  This program is designed for recent college graduates from underrepresented backgrounds who are interested in diabetes and related health issues, offering them a two-year hands-on research experience and support to help them pursue advanced degrees in biomedical fields.

  NIH research Washington University · Saint Louis, United States · NIH-10974855

• Training diverse graduates in diabetes and metabolic disease research

  The Minnesota Postbaccalaureate Research Education Program (MN PRIDE) is a friendly two-year program for diverse college graduates who want to dive into diabetes research, where they'll take advanced classes and work with experienced mentors to build their research skills and get ready for doctoral studies.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10974621

• Editing genes to treat metabolic diseases before and after birth

  This study is exploring new ways to use gene editing to help people with metabolic diseases, both before they are born and after, by fixing harmful genes with a special technology called CRISPR.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10896255

• Understanding the links between heart, kidney, and metabolic diseases

  This study is looking at how obesity and diabetes can lead to heart and kidney problems, especially for people in Mississippi, and it aims to find better ways to treat these issues by working with a team of scientists from different areas.

  NIH research University of Mississippi Med Ctr · Jackson, United States · NIH-10886511

Related topics

Quick answers

How many Metabolic Diseases clinical trials are recruiting right now?

19, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (6 trials), China (5 trials), Germany (2 trials), Chile (1 trial), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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