Investigating the role of lipid hydroperoxides in muscle loss and weakness in older adults
Lipid hydroperoxides in sarcopenia and muscle wasting: mechanisms and intervention
This study is looking at how certain harmful substances in the body might cause muscle loss and weakness in older adults, and it’s testing a treatment that could help improve muscle health and strength as we age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma City VA Medical Center NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11098418 on NIH RePORTER |
What this research studies
This research focuses on understanding how lipid hydroperoxides contribute to sarcopenia, a condition characterized by muscle loss and weakness in older adults. The study aims to explore the mechanisms behind this process, particularly how these compounds may disrupt neuromuscular junctions and lead to mitochondrial dysfunction. By testing a specific treatment that reduces lipid hydroperoxides, the research seeks to identify potential interventions that could improve muscle health and function in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 70 years of age, who are experiencing muscle weakness or loss.
Not a fit: Patients who are younger than 70 years or do not have any signs of muscle loss or weakness may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent or reverse muscle loss in older adults, improving their quality of life.
How similar studies have performed: While the specific approach of targeting lipid hydroperoxides in sarcopenia is novel, similar research has shown promise in understanding muscle deterioration in aging populations.
Where this research is happening
Oklahoma City, United States
- Oklahoma City VA Medical Center — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Brown, Jacob Levi — Oklahoma City VA Medical Center
- Study coordinator: Brown, Jacob Levi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.