Investigating the role of lipid hydroperoxides in muscle loss and weakness in older adults
Official title: Lipid hydroperoxides in sarcopenia and muscle wasting: mechanisms and intervention
Funded at Oklahoma City VA Medical Center · NIH-11098418 · Data updated 2026-11-12
This study is looking at how certain harmful substances in the body might cause muscle loss and weakness in older adults, and it’s testing a treatment that could help improve muscle health and strength as we age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma City VA Medical Center NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5IK2BX005620-04 |
| Project ID | NIH-11098418 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those over 70 years of age, who are experiencing muscle weakness or loss.
✕Less likely to help
Patients who are younger than 70 years or do not have any signs of muscle loss or weakness may not benefit from this research.
What this research studies
This research focuses on understanding how lipid hydroperoxides contribute to sarcopenia, a condition characterized by muscle loss and weakness in older adults. The study aims to explore the mechanisms behind this process, particularly how these compounds may disrupt neuromuscular junctions and lead to mitochondrial dysfunction. By testing a specific treatment that reduces lipid hydroperoxides, the research seeks to identify potential interventions that could improve muscle health and function in aging populations.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent or reverse muscle loss in older adults, improving their quality of life.
How similar studies have gone: While the specific approach of targeting lipid hydroperoxides in sarcopenia is novel, similar research has shown promise in understanding muscle deterioration in aging populations.
Where this research is happening
-
Oklahoma City VA Medical Center
Oklahoma City, United States Active
Researchers
- Principal investigator: Brown, Jacob Levi — Oklahoma City VA Medical Center
- Study coordinator: Brown, Jacob Levi
Related research
Other NIH-funded projects on the same topics.
-
Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis
This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.
-
MiRNA roles in age-related muscle loss and NMJ health
This project explores how small RNA molecules called miRNAs influence muscle aging and the neuromuscular junction in adults.
-
Multiscale microgels delivering GDNF and agrin to help with sarcopenia
Aimed at older adults with muscle loss, this project tests a new treatment that slowly releases biological factors to support nerve-muscle connections and improve strength when combined with or for people who can’t do intense resistance training.
-
Frailty and sarcopenia in aging adults
Aging adults, especially women, may develop frailty and muscle loss, and this project explores how muscle blood flow and inflammation relate to these conditions and to dementia and heart problems.
-
High-field MRI to detect muscle changes in age-related muscle loss
Very strong MRI scans will measure muscle quality, fat, and chemistry in older adults with sarcopenia.
-
LA-rich oil to help strong muscles as we age
A study will test whether adding a linoleic acid–rich oil to the diet improves muscle strength and walking ability in older adults with sarcopenia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.