Prehab and Creatine/Whey Supplements in Cirrhosis-Related Frailty

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study combines a digital prehabilitation program (HEAL-ME) with creatine and whey protein supplementation to see if it preserves muscle health in patients with cirrhosis. Participants must have access to a digital device, be able to consent, and stay in the study for at least 3 months. The intervention arms include HEAL-ME, creatine, whey protein, and a placebo, with eligibility excluding milk protein allergy and certain safety concerns. The study is led by UCSF and conducted at UCSF in San Francisco. No collaborating sites are listed.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Confirmed diagnosis of cirrhosis by ICD-10 code, liver biopsy, abdominal imaging, or transient elastography
* Access to digital device and internet at home
* Ability to provide written informed consent before any study-related activities
* Ability to remain in study for at least 3 months

Exclusion Criteria:

* Allergy to milk protein
* On hemodialysis
* No English language proficiency
* Presence of condition or abnormality that in opinion of the Investigator will compromise safety of the patient or quality of the data
* Concomitant severe underlying systemic illness that in the opinion of the Investigator would interfere with completion of study
* Pregnant, breastfeeding, or intention of becoming pregnant during study time frame

Where it's running

• University of California San Francisco
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Jennifer Lai, MD, MBA — University of California, San Francisco
• Study coordinator: Melinda Wang, MD, MHS
• Email: melinda.wang3@ucsf.edu
• Phone: 415-476-2777

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.