Creatine HCl to improve muscle mass and strength in older adults with sarcopenia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial randomizes adults over 60 with low handgrip strength to receive creatine HCl or placebo for 12 weeks in a double-blind design. Outcomes include body composition, functional muscle performance, cognitive tests, and key blood biomarkers linked to muscle and metabolic health. The study also measures tissue creatine changes using non-invasive imaging and biochemical assays to explore mechanisms of action. Results aim to clarify whether creatine HCl is a viable nutritional approach for managing sarcopenia in the geriatric population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 60 years
* Low muscle strength by handgrip (SDOC criteria for sarcopenia): \< 35.5 kg in men and \< 20 kg in women
* Sign free and informed consent
* Demonstrate interest, conditions and availability to participate

Exclusion Criteria:

* Patients undergoing interventional treatment for sarcopenia
* Physical amputation
* Cognitive impairment (MSSE \< 25)
* Unwillingness to return for follow-up analysis
* Participation in other clinical trials

Where it's running

• Center for Health Sciences
  Belgrade, Serbia Recruiting

Study contacts

• Study coordinator: Sergej Ostojic, MD, PhD
• Email: sergej.ostojic@chess.edu.rs
• Phone: +381112643242

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.