Creatine HCl to improve muscle mass and strength in older adults with sarcopenia
Impact of 12-Week Creatine HCl Supplementation on Body Composition, Functional Muscle and Brain Performance, Blood Biomarkers, and Tissue Creatine Levels in Older Adults With Sarcopenia
NA · Center for Health Sciences, Serbia · NCT07285226
This 12-week randomized, double-blind test will see if daily creatine HCl helps older adults with sarcopenia improve muscle mass, strength, function, and related blood markers.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | Center for Health Sciences, Serbia (other) |
| Locations | 1 site (Belgrade) |
| Trial ID | NCT07285226 on ClinicalTrials.gov |
What this trial studies
The trial randomizes adults over 60 with low handgrip strength to receive creatine HCl or placebo for 12 weeks in a double-blind design. Outcomes include body composition, functional muscle performance, cognitive tests, and key blood biomarkers linked to muscle and metabolic health. The study also measures tissue creatine changes using non-invasive imaging and biochemical assays to explore mechanisms of action. Results aim to clarify whether creatine HCl is a viable nutritional approach for managing sarcopenia in the geriatric population.
Who should consider this trial
Good fit: Ideal candidates are adults over 60 with low handgrip strength (men <35.5 kg, women <20 kg), able to give informed consent, available for follow-up visits, and not enrolled in other interventional trials.
Not a fit: Patients receiving other interventional treatments for sarcopenia, with limb amputation, significant cognitive impairment (MSSE <25), or unwilling/unable to attend follow-up visits are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, creatine HCl could offer a low-cost nutritional option to increase muscle mass, strength, and functional ability in older adults with sarcopenia.
How similar studies have performed: Prior research with creatine monohydrate, particularly when combined with resistance training, has shown improvements in muscle mass and strength in older adults, but creatine HCl has been less extensively studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 60 years * Low muscle strength by handgrip (SDOC criteria for sarcopenia): \< 35.5 kg in men and \< 20 kg in women * Sign free and informed consent * Demonstrate interest, conditions and availability to participate Exclusion Criteria: * Patients undergoing interventional treatment for sarcopenia * Physical amputation * Cognitive impairment (MSSE \< 25) * Unwillingness to return for follow-up analysis * Participation in other clinical trials
Where this trial is running
Belgrade
- Center for Health Sciences — Belgrade, Serbia (RECRUITING)
Study contacts
- Study coordinator: Sergej Ostojic, MD, PhD
- Email: sergej.ostojic@chess.edu.rs
- Phone: +381112643242
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Sarcopenia