Sarcopenia in older adults with acute heart failure: using muscle ultrasound and biomarkers to predict outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Older adults (80+) hospitalized for acute heart failure with preserved ejection fraction are evaluated for sarcopenia using muscle ultrasound, strength tests, and blood biomarkers. The goal is to see if these measures together can better predict discharge outcomes and prognosis. It is an observational study conducted at a single center, focusing on prognosis rather than treatment effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with HF-pEF (LVEF ≥50%), hospitalized for AHF, with signs of fluid overload and requiring intravenous diuretic treatment. The diagnosis of HF will be made in accordance with ESC-2021 guidelines based on the presence of typical signs and symptoms, elevated natriuretic peptides (BNP \>100 pg/mL or NTproBNP \>300 pg/mL), and evidence of underlying structural heart disease by transthoracic echocardiography (performed during admission or within a period of 24 months prior to admission).
* Age ≥ 80 years.
* NYHA functional class II-IV.

Exclusion Criteria:

* End-of-life care.
* Inability to comply with study procedures.
* Already included patients on readmission.

Where it's running

• Hospital Universitario Ramon y Cajal
  Madrid, Madrid, Spain Recruiting

Study contacts

• Principal investigator: Alberto Pérez Nieva — Hospital Universitario Ramon y Cajal
• Study coordinator: Alberto Pérez-Nieva, MD
• Email: apnieva@salud.madrid.org
• Phone: +34 913 36 80 00

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.