Functional Muscle-Bone Incongruity Index: A look at muscle strength and bone health in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, single-center observational study in adults at a rehabilitation clinic. Researchers will compute the Functional Muscle-Bone Incongruity Index (FKUI) from handgrip strength and lumbar-hip DXA bone density data collected during routine assessments. The goal is to determine whether FKUI provides a more comprehensive view of musculoskeletal status than BMD or strength alone. No treatments or interventions are given as part of the study. About 200 participants are expected to enroll and share their existing clinical data for analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Attendance at the Physical Medicine and Rehabilitation outpatient clinic
* Scheduled to undergo routine bone mineral density assessment by DXA as part of clinical evaluation
* Ability to perform handgrip strength testing
* Availability of lumbar spine and total hip bone mineral density measurements suitable for analysis
* Ability and willingness to provide written informed consent

Exclusion Criteria:

Exclusion Criteria:

* Age younger than 18 years
* Secondary causes of osteoporosis (e.g., hyperparathyroidism, Cushing syndrome, malignancy, or other conditions affecting bone metabolism)
* History of metabolic bone disease
* Major trauma or fracture within the previous 6 months
* Upper extremity disorders that may significantly affect handgrip strength measurement (e.g., severe osteoarthritis, neurological disorders, major deformities)
* DXA measurements that are technically inadequate or unsuitable for analysis
* Refusal or inability to provide written informed consent

Where it's running

• Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey
  Küçükçekmece, Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Dilek Ün Oğuzhanasiltürk, MD
• Email: dilekunoguzhan@gmail.com
• Phone: +90 5056367184

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.