Resveratrol with strength training for older adults
Official title: Resveratrol-mediated Changes in Extracellular Vesicle microRNA Cargo as a Novel Contributor to Resistance Training-induced Skeletal Muscle Adaptations in Older Adults
Run by Texas Tech University · NCT06585865 · Data updated 2026-11-12
This program will test whether taking a daily resveratrol pill helps people aged 60+ gain more muscle and strength and improve blood vessel and brain health when they follow supervised strength training.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 60 Years and up |
| Sex | All |
| Enrollment | 36 (estimated) |
| Sponsor | Texas Tech University Academic / other |
| Locations | 1 site (Lubbock, Texas) |
| Status | Recruiting |
| Started | June 13, 2025 |
| Main results expected | July 2027 |
| Study ends | August 2027 |
| Registry record updated | July 7, 2026 |
| Trial ID | NCT06585865 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 60 or older who are minimally active (less than 1 hour of structured exercise per week), have not done resistance training in the prior 6 months, are not currently taking resveratrol, weigh at least 110 pounds, and are medically cleared for supervised exercise.
✕Probably not a fit
People with medical conditions that increase exercise risk (for example cardiovascular disease, uncontrolled hypertension, diabetes, kidney disease, or major orthopedic limitations), current cannabis or nicotine users, or those who exceed the alcohol limit are unlikely to be eligible or to receive benefit from this specific program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Healthy adults age 60 and older who are minimally active will be screened, consented, and complete baseline testing before entering the intervention. Participants will be assigned in a double-blinded manner to take 500 mg resveratrol or placebo daily while completing supervised resistance training three times per week in two six-week blocks with testing weeks after each block. Investigators will measure skeletal muscle adaptations, circulating extracellular vesicles and their cargo, vascular function, and cognitive outcomes to link biological signals with functional responses. Safety monitoring and exercise supervision are provided, and common exclusions include major cardiovascular, metabolic, renal, or orthopedic conditions as well as recent resistance training or certain substance use.
Why it matters
Potential benefit: If successful, combining resveratrol with strength training could help older adults gain more muscle and strength and produce greater improvements in vascular and brain health than exercise alone.
How similar studies have gone: Small clinical studies have shown mixed but promising effects of resveratrol on vascular function and metabolism in older adults, but evidence that it enhances muscle gains with resistance training is limited, making this combination relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 60+ * Minimally active (less than 1 hour of structured exercise/week other than walking) * No resistance training for the previous 6 months * Not currently taking resveratrol supplements * Stable medication, supplement, dietary, and physical activity regimens for the previous 3 months and no plans to change throughout the study period * Body mass at least 110 lbs Exclusion Criteria: * Medical complications that could increase risk during exercise (e.g., cardiovascular disease, uncontrolled hypertension, type 1 or 2 diabetes, orthopedic contraindication to exercise, kidney disease, etc.) * Cannabis or nicotine use * Consume more than 7 alcohol-containing beverages per week
Where it's running
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Department of Kinesiology & Sport Management, Texas Tech University
Lubbock, Texas, United States Recruiting
Study contacts
- Principal investigator: Danielle E Levitt, PhD — Texas Tech University
- Study coordinator: Danielle E Levitt, PhD
- Email: danielle.levitt@ttu.edu
- Phone: 806-834-1830
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.