Identifying factors to improve frailty in critically ill patients
Identifying Modifiable PAtient Centered Therapeutics Frailty: An Observational Cohort Study
This study looks at critically ill patients to see if certain factors can help improve their frailty and recovery by tracking muscle loss and health over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of California, Los Angeles Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT04717869 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on critically ill patients to identify modifiable risk factors associated with sarcopenia, which is closely linked to frailty. By utilizing ultrasound and biomarker analysis, the study aims to track the development and recovery of frailty in this population. The goal is to understand how sarcopenia can serve as a marker for frailty and to explore potential therapeutic measures to improve patient outcomes. The study will involve adult patients admitted to specific ICUs and will monitor their condition over time.
Who should consider this trial
Good fit: Ideal candidates include adult patients admitted to the Surgical, Cardiothoracic, or Neuro ICU with an ICU stay longer than 24 hours.
Not a fit: Patients with muscular or mitochondrial diseases, preexisting paralysis, or those under 18 years old may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to targeted interventions that improve recovery and reduce complications for frail patients in critical care.
How similar studies have performed: While there is ongoing research into frailty and sarcopenia, this specific approach of tracking modifiable risk factors in critically ill patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients admitted to the Surgical, Cardiothoracic or Neuro ICU * ICU stay longer than 24 hours Exclusion Criteria: * Patients with muscular or mitochondrial diseases affecting muscle quality or mass * Preexisting paralysis * Absence of lower limbs * Ongoing discussions about goals of care * Transfers from a skilled nursing facility * Children under the age of 18
Where this trial is running
Los Angeles, California
- Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine — Los Angeles, California, United States (Recruiting)
Study contacts
- Principal investigator: Cecilia Canales, MD, MPH — UCLA Department of Anesthesiology and Perioperative Medicine
- Study coordinator: Jennifer Scovotti, MA
- Email: jscovotti@mednet.ucla.edu
- Phone: 3102064484
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.