Identifying factors to improve frailty in critically ill patients
Official title: Identifying Modifiable PAtient Centered Therapeutics Frailty: An Observational Cohort Study
Run by University of California, Los Angeles · NCT04717869 · Data updated 2026-11-12
This study looks at critically ill patients to see if certain factors can help improve their frailty and recovery by tracking muscle loss and health over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | University of California, Los Angeles Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Status | Recruiting |
| Started | September 22, 2023 |
| Main results expected | May 2026 |
| Study ends | July 2026 |
| Registry record updated | January 30, 2026 |
| Trial ID | NCT04717869 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adult patients admitted to the Surgical, Cardiothoracic, or Neuro ICU with an ICU stay longer than 24 hours.
✕Probably not a fit
Patients with muscular or mitochondrial diseases, preexisting paralysis, or those under 18 years old may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on critically ill patients to identify modifiable risk factors associated with sarcopenia, which is closely linked to frailty. By utilizing ultrasound and biomarker analysis, the study aims to track the development and recovery of frailty in this population. The goal is to understand how sarcopenia can serve as a marker for frailty and to explore potential therapeutic measures to improve patient outcomes. The study will involve adult patients admitted to specific ICUs and will monitor their condition over time.
Why it matters
Potential benefit: If successful, this study could lead to targeted interventions that improve recovery and reduce complications for frail patients in critical care.
How similar studies have gone: While there is ongoing research into frailty and sarcopenia, this specific approach of tracking modifiable risk factors in critically ill patients is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients admitted to the Surgical, Cardiothoracic or Neuro ICU * ICU stay longer than 24 hours Exclusion Criteria: * Patients with muscular or mitochondrial diseases affecting muscle quality or mass * Preexisting paralysis * Absence of lower limbs * Ongoing discussions about goals of care * Transfers from a skilled nursing facility * Children under the age of 18
Where it's running
-
Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine
Los Angeles, California, United States Recruiting
Study contacts
- Principal investigator: Cecilia Canales, MD, MPH — UCLA Department of Anesthesiology and Perioperative Medicine
- Study coordinator: Jennifer Scovotti, MA
- Email: jscovotti@mednet.ucla.edu
- Phone: 3102064484
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.