Renal rehabilitation with low-dialysate-flow daily hemodialysis for people on hemodialysis
Benefits of a Renal Rehabilitation Program Adapted to Uremic Patients on Daily Hemodialysis at Low Dialysate Flow Rate.
This tests whether combining a tailored rehab program (exercise + nutrition) with low-dialysate-flow daily hemodialysis helps people on hemodialysis who are at risk of muscle loss (sarcopenia).
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Brugmann University Hospital Academic / other |
| Locations | 1 site (Brussels) |
| Trial ID | NCT07413315 on ClinicalTrials.gov |
What this trial studies
This interventional program pairs a multidisciplinary renal rehabilitation plan (structured physical exercise and nutritional monitoring) with low-dialysate-flow hemodialysis delivered more frequently. It targets patients with end-stage chronic kidney disease on hemodialysis, a group with high rates of sarcopenia and post-dialysis symptoms. Eligible participants are recently hospitalized but must be medically stable and free of major cognitive, cardiac, or neurologic contraindications. The study site is CHU Brugmann in Brussels and outcomes are expected to include changes in muscle mass, functional capacity, and dialysis tolerance.
Who should consider this trial
Good fit: Ideal candidates are adults with end-stage CKD who require ongoing hemodialysis and are recently hospitalized but medically stable without major cardiac, cognitive, or neurologic contraindications.
Not a fit: Patients with significant cognitive impairment, unstable or severe cardiac disease, certain acute infections or inflammatory cardiac conditions, pregnancy, recovery of kidney function, or recent spinal cord injury are unlikely to be eligible or to benefit.
Why it matters
Potential benefit: If successful, the approach could improve muscle strength and physical function, reduce post-dialysis symptoms, and improve quality of life for people on hemodialysis.
How similar studies have performed: Previous work on intradialytic exercise and multidisciplinary renal rehabilitation has shown improvements in physical function and sarcopenia in dialysis populations, though combining these programs with low-dialysate-flow daily hemodialysis is less well studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patient with terminal chronic kidney disease requiring hemodialysis treatment * patient recently hospitalized for an acute medical event. Exclusion Criteria: * dementia/mild cognitive impairment (MMSE \< 20/30) * decompensated psychiatric pathology and/or behavioral disorders * pregnant woman * recovery of renal function allowing interruption of helodialysis sessions * candidate for neurological rehabilitation * patient with recent spinal cord injury * patient with absolute and/or relative contraindication to performing a stress test * severe or poorly tolerated cardiac rhythm disorder * severe or symptomatic obstruction to left ventricular ejection * decompensated heart failure * acute myocarditis, pericarditis or endocarditis * acute aortic dissection * high-risk emboligenic intracardiac thrombus * significant stenosis of the common trunk * ventricular aneurysm * supraventricular tachycardia with poorly controlled ventricular rate, acquired high-degree or complete block * obstructive cardiomyopathy with high resting gradient * recent stroke or TIA * acute venous thrombosis with or without pulmonary embolism * poorly controlled clinical condition, such as marked anemia, significant electrolyte disturbance, hyperthyroidism, etc. * lack of cooperation from the patient * Blood pressure \> 200/110 mmHg
Where this trial is running
Brussels
- CHU Brugmann — Brussels, Belgium (Recruiting)
Study contacts
- Principal investigator: Joris Vanparys, MD — CHU Brugmann
- Study coordinator: Joris Vanparys, MD
- Email: Joris.VANPARYS@chu-brugmann.be
- Phone: +32 2475 52 64
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.