Renal rehabilitation with low-dialysate-flow daily hemodialysis for people on hemodialysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional program pairs a multidisciplinary renal rehabilitation plan (structured physical exercise and nutritional monitoring) with low-dialysate-flow hemodialysis delivered more frequently. It targets patients with end-stage chronic kidney disease on hemodialysis, a group with high rates of sarcopenia and post-dialysis symptoms. Eligible participants are recently hospitalized but must be medically stable and free of major cognitive, cardiac, or neurologic contraindications. The study site is CHU Brugmann in Brussels and outcomes are expected to include changes in muscle mass, functional capacity, and dialysis tolerance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patient with terminal chronic kidney disease requiring hemodialysis treatment
* patient recently hospitalized for an acute medical event.

Exclusion Criteria:

* dementia/mild cognitive impairment (MMSE \< 20/30)
* decompensated psychiatric pathology and/or behavioral disorders
* pregnant woman
* recovery of renal function allowing interruption of helodialysis sessions
* candidate for neurological rehabilitation
* patient with recent spinal cord injury
* patient with absolute and/or relative contraindication to performing a stress test
* severe or poorly tolerated cardiac rhythm disorder
* severe or symptomatic obstruction to left ventricular ejection
* decompensated heart failure
* acute myocarditis, pericarditis or endocarditis
* acute aortic dissection
* high-risk emboligenic intracardiac thrombus
* significant stenosis of the common trunk
* ventricular aneurysm
* supraventricular tachycardia with poorly controlled ventricular rate, acquired high-degree or complete block
* obstructive cardiomyopathy with high resting gradient
* recent stroke or TIA
* acute venous thrombosis with or without pulmonary embolism
* poorly controlled clinical condition, such as marked anemia, significant electrolyte disturbance, hyperthyroidism, etc.
* lack of cooperation from the patient
* Blood pressure \> 200/110 mmHg

Where it's running

• CHU Brugmann
  Brussels, Belgium Recruiting

Study contacts

• Principal investigator: Joris Vanparys, MD — CHU Brugmann
• Study coordinator: Joris Vanparys, MD
• Email: Joris.VANPARYS@chu-brugmann.be
• Phone: +32 2475 52 64

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.