Condition

Cirrhosis clinical trials and research

• 78Clinical trials
• 92NIH research projects
• 1New in 30 days
• 27Countries

Newest Cirrhosis clinical trials

All recruiting trials (78)

• Endovascular treatment outcomes after portal hypertension–related GI bleeding in cirrhosis

  This study tests how well endovascular procedures for portal hypertension–related GI bleeding work in adults with cirrhosis, and what factors predict outcomes.

  Recruiting University Medical Center Ho Chi Minh City (UMC) · Ho Chi Minh City · NCT07918378

• EUS-guided coil and glue vs glue injection for bleeding gastric varices in cirrhosis

  This trial tests whether using endoscopic ultrasound to guide coils plus glue works better than glue alone for stopping bleeding from gastric varices in adults with cirrhosis.

  Recruiting Medanta, The Medicity, India · Orlando, Florida and 1 other locations · NCT07855913

• 4D-Flow MRI to see portal hypertension and TIPS outcomes in cirrhosis

  This study tests a noninvasive 4D-Flow MRI method to see if it can safely and reliably reflect portal hypertension and predict outcomes for people with cirrhosis, including those needing a TIPS procedure.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT07554183

• Apixaban plus carvedilol to prevent portal-hypertension complications in cirrhosis

  This will test whether adding apixaban to carvedilol can help prevent variceal bleeding, portal vein thrombosis, and other portal-hypertension complications in adults with Child-Pugh B cirrhosis.

  Recruiting Phase 4 Asian Institute Of Medical Sciences · Hyderābād, Sindh · NCT07521332

• Factors that affect reopening of blocked portal veins in people with cirrhosis and gastroesophageal varices

  This project looks at past records and follow-up to see which factors are linked with reopening (recanalization) of blocked portal veins in people who have cirrhosis and endoscopy-confirmed gastroesophageal varices.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07473375

• Copper supplementation for people with cirrhosis

  This trial will try giving copper supplements to adults with cirrhosis who have low copper levels or signs of copper deficiency to see if liver-related health improves.

  Recruiting University of Washington · Seattle, Washington · NCT07471542

• Biannual liver cancer screening with ultrasound and AFP for compensated non‑viral cirrhosis in Central Denmark

  This program will try giving people aged 40–79 with compensated non‑viral cirrhosis ultrasound scans plus AFP blood tests every six months to see if screening lowers deaths from liver cancer.

  Recruiting at 6 sites University of Aarhus · Aarhus, Central Jutland and 5 other locations · NCT07469319

• Vagus nerve–guided laparoscopic spleen removal with azygoportal disconnection

  This procedure tests whether a vagus nerve–guided laparoscopic spleen removal plus azygoportal disconnection helps people with cirrhosis, portal hypertension, and hypersplenism who have had gastroesophageal variceal bleeding.

  Recruiting Northern Jiangsu People's Hospital · Yangzhou, Jiangsu and 1 other locations · NCT07462091

• Apixaban for portal vein clots that appear more than a year after laparoscopic splenectomy

  This trial tests whether taking apixaban twice daily can treat portal vein blood clots that develop more than a year after laparoscopic splenectomy in people with cirrhosis.

  Recruiting Northern Jiangsu People's Hospital · Yangzhou, Jiangsu · NCT07461545

• Apixaban for portal vein thrombosis occurring more than one year after laparoscopic splenectomy and azygoportal disconnection

  This trial will try whether taking apixaban 2.5 mg twice daily can treat portal vein clots that appear more than a year after laparoscopic splenectomy and azygoportal disconnection in people with cirrhosis.

  Recruiting Northern Jiangsu People's Hospital · Yangzhou, Jiangsu · NCT07461532

• Comparing HVPG and endoscopic ultrasound portal pressure measurements

  This study will test whether an endoscopic ultrasound method (EUS-PPG) gives the same portal pressure readings as the standard hepatic venous pressure gradient (HVPG) in adults who need portal pressure measurement.

  Recruiting at 2 sites Military University Hospital, Prague · Prague, Bohemia and 1 other locations · NCT07424963

• Frailty, Nutrition, and Recovery in People Waiting for a Liver Transplant

  This project will test whether measures of frailty, muscle loss, nutrition, and psychological health can predict outcomes for adults (18–65) on the liver transplant waiting list in Turkey.

  Recruiting Izmir Bakircay University · Izmir · NCT07414095

• Nerve and heart activity in hepatocellular carcinoma (HCC)

  This project will test whether measuring autonomic nervous system signals—such as heart rate patterns, sensory‑response tests, and liver biopsy markers—can help detect or better characterize HCC in adults with compensated cirrhosis who are having a liver biopsy.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07393074

• Diastolic improvement with carvedilol and empagliflozin for people with cirrhosis

  This test will see if adding empagliflozin to carvedilol improves diastolic heart function and reduces decompensation events in adults with cirrhosis and left ventricular diastolic dysfunction.

  Recruiting Phase 4 Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh · NCT07322237

• TIPS procedure with or without oral branched-chain amino acids (BCAA)

  This test will try giving oral BCAA supplements for three months after TIPS in adults with cirrhosis and sarcopenia to see if it improves muscle and clinical outcomes.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan · NCT07281846

• Microplastics in the liver of people with cirrhosis and portal hypertension

  This study tests whether microplastics and nanoparticles accumulate in the livers of adults with cirrhosis and portal hypertension who are undergoing surgery or transplant, to understand where they go and what form they take.

  Recruiting at 2 sites Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh, Chandigarh and 1 other locations · NCT07280390

• How TIPS affects liver recompensation in people with decompensated cirrhosis

  This observational project will see if placing a transjugular intrahepatic portosystemic shunt (TIPS) helps adults (18–80) with decompensated cirrhosis from treatable causes to achieve liver recompensation and improve survival.

  Recruiting at 15 sites Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Changsha and 14 other locations · NCT07172035

• Serum AKR1B10 as an early-warning marker for hepatocellular carcinoma in cirrhosis

  This study will test whether a blood test for AKR1B10 can help detect early liver cancer in adults with cirrhosis.

  Recruiting The First Affiliated Hospital of University of South China · Hengyang, Hunan · NCT07147335

• Comparing blood thinners for people with cirrhosis and portal vein clots

  This will try enoxaparin, warfarin, or apixaban in people with cirrhosis and portal vein thrombosis (with or without liver cancer) to see which controls the clot and is safest.

  Recruiting Phase 4 Mansoura University · Al Mansurah, Dakahlia Governorate · NCT07132515

• Melatonin to improve sleep and thinking in people with cirrhosis

  This study will try one month of daily melatonin (compared with one month of thiamine) to see if it improves sleep and thinking in adults with cirrhosis and hepatic encephalopathy.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT07046429

• Zanzalintinib for advanced liver cancer after prior treatment

  This phase Ib/II study tests if zanzalintinib is safe and tolerable and if it can help people with advanced liver cancer after other therapies.

  Recruiting Phase 1/2 Northwestern University · Chicago, Illinois · NCT07042919

• Natural course of advanced chronic liver disease (cirrhosis)

  We will follow adults with advanced chronic liver disease for 10 years and use yearly transient elastography to see if and when liver complications or liver-related death occur.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT07042308

• Non-invasive tests to predict outcomes after curative treatment for hepatocellular carcinoma

  This project will test whether regular non-invasive liver and spleen stiffness checks plus scheduled endoscopies can help predict future complications in people with compensated chronic liver disease who receive curative-intent treatment for HCC.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT07036874

• A prognostic model that adds nutritional and metabolic measures for liver cirrhosis

  This project will test whether adding objective nutritional measurements and metabolic profiles to routine clinical data can better predict outcomes for adults with liver cirrhosis.

  Recruiting The Second Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT07031843

• Prehab and Creatine/Whey Supplements in Cirrhosis-Related Frailty

  This study tests whether a digital prehabilitation app plus creatine and whey protein can help maintain muscle health in people with cirrhosis and frailty.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07029243

• Examining breath markers in liver disease patients

  This study is trying to see if certain breath markers can help identify and understand the progression of liver disease in patients, especially those with cirrhosis.

  Recruiting at 3 sites Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality and 2 other locations · NCT06968234

• How low blood sugar at night affects muscle loss in cirrhosis

  This will see if episodes of low blood sugar, especially overnight, speed up muscle loss in adults with cirrhosis by using a wearable glucose sensor, food records, and health questionnaires.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT06948656

• Outcomes of adults with cirrhosis admitted to the general ICU (2014–2024)

  This project will see if adults with cirrhosis admitted to the ICU from 2014 to 2024 had better survival, access to liver transplantation, and ICU care practices than reported before 2014.

  Recruiting Centre Hospitalier Universitaire de Besancon · Besançon · NCT06948565

• Bumetanide vs. Furosemide for Diuresis in Cirrhosis

  This study tests whether bumetanide works better than furosemide to reduce fluid overload in adults with cirrhosis who are hospitalized.

  Recruiting Phase 3 University of Utah · Salt Lake City, Utah · NCT06941415

• Using droxidopa to improve kidney function in patients with liver cirrhosis and kidney injury

  This study is testing if an oral medication called droxidopa can help improve kidney function and blood pressure in hospitalized patients with liver cirrhosis and kidney injury.

  Recruiting Phase 2 Columbia University · New York, New York · NCT06937307

• Nutritional program to reduce frailty in people waiting for a liver transplant

  This trial will try a targeted nutritional management program to see if it reduces frailty in adults with cirrhosis who are on the liver transplant waiting list.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06911619

• Using Tranexamic Acid and Vitamin K to Treat Upper Gastrointestinal Bleeding in Cirrhotic Patients

  This study is testing whether giving Tranexamic acid and vitamin K can help control bleeding in the stomach for people with liver cirrhosis.

  Recruiting Phase 4 Tanta University · Tanta, Gharbyea · NCT06881628

• EUS-guided portal pressure measurement as an alternative to hepatic venous pressure

  This trial will test whether an endoscopic ultrasound-guided portal pressure measurement (EUS-PPG) gives the same portal pressure readings as the standard HVPG in adults with portal hypertension from chronic liver disease.

  Recruiting Fundacio Privada Mon Clinic Barcelona · Barcelona · NCT06863012

• Carvedilol effect on portal pressure measured by endoscopic ultrasound

  We will test whether one month of carvedilol (titrated to 12.5 mg daily) lowers portal pressure to help prevent digestive bleeding in adults with cirrhosis.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand and 1 other locations · NCT06861075

• Using albumin to help with fluid removal in patients with liver disease and swelling

  This study is testing whether giving albumin to people with liver disease and swelling can help them get rid of extra fluid better than just using regular saline.

  Recruiting Phase 2 VA Connecticut Healthcare System · West Haven, Connecticut · NCT06812390

• Using inhaled amikacin to prevent pneumonia in cirrhosis patients on ventilators

  This study is testing if inhaled amikacin can help prevent pneumonia in patients with cirrhosis who are on ventilators.

  Recruiting at 2 sites Phase 4 Asian Institute of Gastroenterology, India · Hyderabad, Telangana and 1 other locations · NCT06808074

• How TIPS may improve muscle loss in cirrhosis and the role of FGF21

  This project tests whether TIPS helps people with cirrhosis regain muscle and whether blood FGF21 levels explain that improvement.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan · NCT06794853

• mSEPT9 biomarker to predict liver cancer in people with cirrhosis

  This study tests whether a blood biomarker called mSEPT9 can predict the development of hepatocellular carcinoma in people with cirrhosis.

  Recruiting Central Hospital, Nancy, France · Vandœuvre-lès-Nancy · NCT06778317

• Atorvastatin plus beta-blockers for people with decompensated cirrhosis

  This pilot Phase 2 trial will test whether adding atorvastatin 20 mg to standard non‑selective beta‑blocker therapy helps adults with decompensated cirrhosis avoid complications over 12 months.

  Recruiting Phase 2 CAMC Health System · Charleston, West Virginia · NCT06764966

• Effects of Metformin on Portal Hypertension in Cirrhosis Patients

  This study is testing if metformin can lower blood pressure in the liver for people with cirrhosis and portal hypertension who haven't had enough success with other treatments.

  Recruiting Phase 2 Assistance Publique - Hôpitaux de Paris · Clichy, France · NCT06687265

• Abbreviated non-contrast MRI versus ultrasound for finding liver cancer in people with cirrhosis

  We will test whether shorter MRI scans without contrast find liver cancer more reliably than routine ultrasound in adults with cirrhosis or otherwise at high risk.

  Recruiting at 2 sites University of Oxford · Oxford, Oxon and 1 other locations · NCT06658782

• Tracking antibiotic resistance in patients with cirrhosis and infections

  This study looks at how common antibiotic resistance is in patients with cirrhosis who get infections to help create better treatment guidelines for doctors in Latin America.

  Recruiting Hospital Italiano de Buenos Aires · Buenos Aires, Buenos Aires F.D. · NCT06634940

• Evaluating carvedilol with or without endoscopic variceal ligation for preventing bleeding in cirrhotic patients

  This study is testing if adding a procedure called endoscopic variceal ligation to the medication carvedilol can better prevent bleeding in people with cirrhosis who aren't helped by carvedilol alone.

  Recruiting Phase 4 Taipei Veterans General Hospital, Taiwan · Taipei · NCT06594783

• Stopping non-selective beta-blockers in people with cirrhosis whose main cause is controlled

  This study will try stopping non-selective beta-blockers in adults with cirrhosis who have their primary liver disease controlled, low liver stiffness, and no varices to see if varices come back within one year.

  Recruiting Chinese University of Hong Kong · Sydney and 7 other locations · NCT06549673

• Evaluation of patient care support for cirrhosis and liver transplants

  This study is trying to gather information from patients with cirrhosis or those needing a liver transplant to better understand the disease and find ways to improve their care.

  Recruiting at 3 sites Assistance Publique - Hôpitaux de Paris · Paris and 2 other locations · NCT06544863

• Modulating gut microbiome with prebiotics in veterans with PTSD and cirrhosis

  This study is testing if giving prebiotics can help improve gut health and overall well-being in veterans who have both PTSD and liver disease.

  Recruiting Hunter Holmes Mcguire Veteran Affairs Medical Center · Richmond, Virginia · NCT06464952

• Using resistant potato starch to treat cirrhosis and hepatic encephalopathy

  This study is testing if eating resistant potato starch can help improve gut health and symptoms in people with cirrhosis and hepatic encephalopathy.

  Recruiting at 2 sites Mayo Clinic · Rochester, Minnesota and 1 other locations · NCT06425380

• Assessing muscle mass and strength in patients with cirrhosis

  This study is testing how muscle mass and strength change in people with cirrhosis to see how it affects their daily lives and health.

  Recruiting University Hospital, Antwerp · Edegem, Antwerpen · NCT06345547

• Exploring how nutrition affects liver cirrhosis prognosis

  This study looks at how nutrition affects the health and survival of people with liver cirrhosis to see if better eating can improve their outcomes.

  Recruiting The Second Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06328517

• Cirrhotic cardiomyopathy and fibrosis in liver transplant candidates using cardiac MRI

  This study tests whether MRI can show changes in heart muscle fibrosis in people awaiting liver transplant and after transplant.

  Recruiting at 3 sites Phase 1 Centre Hospitalier Universitaire de Besancon · Besançon and 3 other locations · NCT06327308

• Noninvasive Prediction of Portal Hypertension in Cirrhosis Using STVi

  This study tests whether the liver STVi ultrasound measurement can noninvasively predict clinically significant portal hypertension in adults with cirrhosis.

  Recruiting First Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT06316869

• Exploring the role of gut bacteria in alcoholic hepatitis

  This study is trying to see how gut bacteria affect liver damage in people with severe alcoholic hepatitis to find new ways to help them feel better.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06307964

• Understanding gastric issues in patients with enlarged stomach blood vessels

  This study is trying to see how often stomach problems like pain and nausea happen in adults with a condition called Gastric Antral Vascular Ectasia and how these issues relate to how well their stomachs work.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06306963

• Comparing 3D and 2D MRI techniques for assessing liver cirrhosis and portal hypertension

  This study is testing whether a new 3D MRI technique can better predict liver pressure issues in people with cirrhosis compared to the standard 2D MRI method.

  Recruiting Shengjing Hospital · Shenyang, Liaoning · NCT06205992

• Using memantine to treat patients with cirrhosis and liver cancer

  This study is testing if memantine can help improve the health and quality of life for patients with liver cancer who can't have major treatments due to cirrhosis.

  Recruiting Phase 2/3 Inova Health Care Services · Fairfax, Virginia and 1 other locations · NCT06007846

• A new system to improve care for hospitalized patients with cirrhosis

  This study is testing a new support system called CirrhosisRx to see if it can help doctors provide better care for hospitalized patients with cirrhosis compared to regular treatment.

  Recruiting University of California, San Francisco · San Francisco, California · NCT05967273

• Evaluating rosuvastatin for treating liver cirrhosis

  This study is testing if the medication rosuvastatin can help improve liver health in people with compensated cirrhosis over a period of 96 weeks.

  Recruiting at 13 sites Phase 2 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · La Jolla, California and 12 other locations · NCT05832229

• Using esmolol to improve heart disease diagnosis in patients with cirrhosis and diabetes

  This study is testing if a special heart test using esmolol can help doctors find hidden heart problems in people with diabetes and liver disease.

  Recruiting at 4 sites Phase 3 Consorcio Centro de Investigación Biomédica en Red (CIBER) · Barcelona, Barcelona and 5 other locations · NCT05769868

• Using empagliflozin to treat patients with cirrhosis and fluid retention

  This study tests whether empagliflozin, a diabetes medication, can help people with cirrhosis and fluid retention feel better by improving their body water levels and kidney function.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT05726032

• Early detection of liver cancer in patients with cirrhosis

  This study is testing new ways to find liver cancer early in people with cirrhosis by looking at blood, urine, and other health information over four years.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT05541601

• Comparing Ultrasound and MRI for Early Detection of Liver Cancer

  This study is testing whether a special type of MRI can find liver cancer earlier than the usual ultrasound in patients with cirrhosis.

  Recruiting at 33 sites VA Office of Research and Development · Birmingham, Alabama and 33 other locations · NCT05486572

• Exploring muscle composition's impact on liver transplant outcomes

  This study is testing how muscle health affects the success of liver transplants in patients with severe liver disease.

  Recruiting Mayo Clinic · Phoenix, Arizona · NCT05477277

• Collecting data to predict cancer risk in at-risk populations

  This study is trying to collect samples and health information from people at higher risk of cancer to see if they can find signs that help predict cancer early on.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT05463796

• Hepatology home hospital program for people with advanced liver disease

  This will try a hospital-at-home program that brings hepatology care to adults with cirrhosis who would otherwise need inpatient care.

  Recruiting at 2 sites Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT05205954

• Treatment of advanced liver cancer with namodenoson in patients with severe cirrhosis

  This study is testing if a new drug called namodenoson can help people with advanced liver cancer and severe cirrhosis feel better and live longer compared to a placebo.

  Recruiting at 11 sites Phase 3 Can-Fite BioPharma · Dallas, Texas and 31 other locations · NCT05201404

• Fast-MRI to improve liver cancer surveillance in high-risk patients

  This trial will test whether adding a fast liver MRI to the routine six-month ultrasound finds early liver cancers sooner in adults with cirrhosis who have an annual HCC risk above 3%.

  Recruiting Assistance Publique - Hôpitaux de Paris · Bondy · NCT05095714

• Treatment for liver impairment in patients with cirrhosis from cholestatic liver disease

  This study is testing a new medication called Saroglitazar Magnesium to see if it can improve liver function and health in people with cirrhosis from cholestatic liver disease.

  Recruiting Phase 1 Zydus Therapeutics Inc. · Indianapolis, Indiana · NCT05045482

• Evaluating atorvastatin's effect on liver cancer risk in patients with advanced fibrosis

  This study is testing if taking atorvastatin can lower the risk of liver cancer in adults with advanced liver fibrosis who are at high risk for developing the disease.

  Recruiting at 2 sites Phase 2 Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT05028829

• EUS-guided measurement of portal pressure gradient

  This study will test an endoscopic ultrasound (EUS) technique to directly measure portal pressure in people with cirrhosis to see if it can safely and accurately indicate portal hypertension.

  Recruiting Phase 1/2 Chinese University of Hong Kong · Hong Kong, Hong Kong · NCT04633356

• Vaccination for liver transplant candidates

  This study tests if getting vaccinated can help people waiting for a liver transplant stay healthier and avoid serious infections.

  Recruiting Hospices Civils de Lyon · Lyon · NCT04446832

• Observational cohort for non-alcoholic fatty liver disease and related conditions

  This study is trying to learn more about non-alcoholic fatty liver disease and its related conditions by looking at patients with different stages of the disease and comparing them to people with diabetes and obesity who don't have it.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, Rome/lazio/italy · NCT04371042

• Investigating microRNAs in patients with decompensated cirrhosis

  This study is testing if certain tiny molecules in blood and stool can help doctors spot early signs of infection in patients with severe liver disease.

  Recruiting Hospices Civils de Lyon · Lyon · NCT03905746

• Evaluation of the Alfapump® device for treating refractory ascites in cirrhotic patients

  This study is testing if the Alfapump® device can help people with cirrhosis and fluid buildup feel better and reduce hospital visits compared to the usual treatment.

  Recruiting at 8 sites University Hospital, Grenoble · Amiens and 9 other locations · NCT03506893

• Evaluating bariatric surgery for treating severe liver disease in obese patients

  This study is testing whether bariatric surgery can help obese patients with severe liver disease get better compared to standard medical treatment.

  Recruiting University Hospital, Lille · Lille · NCT03472157

• Evaluating muscle protein metabolism in patients with cirrhosis

  This study is testing how muscle protein is made and broken down in people with cirrhosis to better understand why they lose muscle.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT03225677

• Examining malnutrition mechanisms in cirrhosis patients

  This study is trying to understand how malnutrition happens in people with cirrhosis by looking at muscle and fat loss, and comparing them to healthy individuals.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT03121404

• Biorepository for liver disease samples

  This study is collecting samples from patients with liver diseases to help researchers find better treatments and improve care for these conditions.

  Recruiting State University of New York at Buffalo · Buffalo, New York · NCT03025074

• Carvedilol to prevent esophageal varices in people with cirrhosis

  This will try whether taking carvedilol twice daily for one year can prevent esophageal varices in adults (18–75) with cirrhosis who do not currently have varices, compared with a placebo.

  Recruiting Institute of Liver and Biliary Sciences, India · New Delhi, National Capital Territory of Delhi · NCT01212250

NIH-funded research (newest 40 of 92)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Statin therapy for people with compensated cirrhosis

  A big, long-term study at a major university is looking at whether statins can help people with compensated cirrhosis live longer and feel better.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11591518

• Liver Cirrhosis Network: Centers for Clinical Research

  A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11591517

• Outcomes in cirrhosis from different causes and the role of HIV and simvastatin

  This study looks at how cirrhosis from alcohol, HIV, and other causes affects patients and whether simvastatin can influence outcomes.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11591516

• Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center

  A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11591514

• Understanding how risk factors affect progression of cirrhosis and response to statins in patients with cirrhosis

  This project follows people with cirrhosis to see what factors speed up their liver disease and whether statin medicines help prevent worsening.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11591513

• Cirrhosis Network study to understand mortality and therapies

  A large, multi-center study in people with cirrhosis to find better ways to predict deaths and test the potential of statins to prevent complications like liver cancer and liver failure.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11591512

• Liver Cirrhosis Network: Longitudinal and Clinical Trial Studies

  A network-wide NIH study focused on understanding cirrhosis better to prevent complications and improve care for people with advanced liver disease.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11591424

• Prediction and Prevention of Liver Decompensation in Cirrhosis Patients

  A study at Duke aims to find factors that cause liver deterioration in people with cirrhosis and test whether a common cholesterol drug (statin) can help prevent worsening liver function.

  NIH research Duke University · Durham, United States · NIH-11591423

• Cirrhosis Patient Cohort Study at USC

  A large, multi-center study follows adults with compensated cirrhosis to better understand how the condition progresses and what factors influence outcomes.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11591410

• Liver Cirrhosis Network: Coordinating Data for Better Care

  A national effort is coordinating data to improve care for people with advanced liver disease and its complications.

  NIH research Northwestern University · Chicago, United States · NIH-11591404

• Liver Cirrhosis Network coordinating cirrhosis studies and a rosuvastatin trial

  This project follows people with liver cirrhosis over time and tests whether the cholesterol medicine rosuvastatin helps people with cirrhosis.

  NIH research Northwestern University · Chicago, United States · NIH-11473501

• Optimizing Emergency Care for Cirrhosis (OCEAN) in the ED

  A research team at Indiana University Indianapolis is studying how to make emergency care for people with cirrhosis safer, faster, and more effective.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11449805

• Proximal Splenic Artery Embolization to Help People with Tough-to-Manage Ascites from Cirrhosis

  A small patient-centered study tests a minimally invasive procedure to reduce ascites and improve quality of life for people with decompensated liver cirrhosis who can’t safely have a TIPS procedure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11448329

• Cirrhosis detection help using an AI tool in medical records

  A new AI-powered approach using electronic health record data aims to improve early cirrhosis detection to help people with alcoholic liver disease get timely care.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11447104

• Chronic pain relief for people with cirrhosis using at-home TEA therapy

  A pilot study will test a new at-home patch therapy (TEA) to reduce chronic pain and improve function for people with cirrhosis.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11443346

• Optimal use of blood thinners for venous clots in people with cirrhosis

  This grant hopes to figure out the safest and most effective way to use oral anticoagulants for adults with cirrhosis who develop venous clots.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11427117

• Novel HNF4α-based nucleotide therapy for end-stage liver disease with cirrhosis

  A new therapy using a nucleotide-LNP to restore a key liver gene could improve liver function and survival for people with severe cirrhosis or liver failure.

  NIH research Masterswitch, INC. · Wilmington, France · NIH-11408899

• First-in-class treatment for liver cirrhosis with portal hypertension

  A new therapy called XFB19 aims to reduce liver inflammation and scarring in people with advanced liver disease and portal hypertension.

  NIH research Xfibra, INC. · Del Mar, UNITED STATES · NIH-11406381

• Cirrosis-related liver cancer prevention with a targeted EGFR treatment

  A study tests whether a low-dose EGFR inhibitor can prevent progression to liver cancer in people with cirrhosis.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11406302

• Fecal transplant to help alcohol-related liver disease

  A clinical trial will test whether a standardized oral fecal microbiota transplant (FMT) capsule can help people with alcohol-related liver disease drink less and feel mentally better.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11402247

• Copper supplementation in cirrhosis: a small trial to see if it helps health and feel better

  A small randomized trial will test whether adding copper helps people with cirrhosis feel better and stay safer from infections and complications.

  NIH research University of Washington · Seattle, United States · NIH-11400284

• Cholesterol Pathways in Acinar Cells and Alcoholic Pancreatitis

  Researchers are studying how cholesterol handling in pancreatic acinar cells affects alcoholic pancreatitis and whether fixing this pathway could lessen disease severity.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11397380

• Understanding how human hepatic stellate cells drive liver fibrosis in alcohol-related disease

  This project studies human liver cells to find the genes and chromatin changes that cause fibrosis in alcohol-related liver disease, to pave the way for future treatments.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11397378

• Southern California Center exploring alcohol-related liver disease and liver cancer

  A national research center based at USC studies how alcohol-related liver disease can lead to liver cancer and seeks new ways to block this progression.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11397376

• Endogenous Retroviruses and Alcohol-Related Liver Disease

  This program studies how alcohol-related liver disease may be influenced by viral elements in our gut and how targeting these parts could help people with this condition.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11397374

• Alcohol-related liver disease research center focusing on ALPD and cirrhosis

  A center-based program studies how alcohol-related liver and pancreatic diseases develop in living systems using animal models and human-like technologies to improve treatments.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11397373

• ALPD and Cirrhosis Research Center Pilot Projects for New Leaders

  A USC center funds pilots led by young and established scientists to push forward understanding and treatment of alcoholic liver disease and cirrhosis.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11397372

• Southern California Center for Alcoholic Liver Disease and Cirrhosis (ALPD)

  A national research center based in Southern California aims to advance understanding and treatment of alcoholic liver disease and cirrhosis by coordinating researchers, training students, and fostering collaborations.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11397370

• Alcohol-related liver disease research center advances new therapies

  A large, multi-institution effort is exploring how alcohol-related liver disease develops and how to treat it.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11397368

• Molecular clues in ascites that may predict infections in cirrhosis

  Researchers will study the fluid in the abdomen of people with cirrhosis to find signs that predict dangerous infections and death.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11387707

• Frailty and outcomes after liver transplant in acutely ill patients

  This grant studies how frailty affects recovery and survival for people with cirrhosis who undergo liver transplantation during an acute hospital stay.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11379527

• HCC Risk Stratification in MAFLD Cirrhosis

  A large, patient-focused effort to identify which people with MAFLD-related cirrhosis are at higher risk for liver cancer and to develop practical tools to stratify that risk.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11379127

• Early detection of liver cancer risk in people with cirrhosis and MASLD

  A small research grant to explore better ways to find liver cancer early among people with cirrhosis and MASLD so they can get timely care.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11356187

• Oral anticoagulants for cirrhosis and atrial fibrillation: which option works best for you

  This project tries to figure out which blood thinner (warfarin or DOACs) works safest and best for people with cirrhosis and atrial fibrillation.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11300998

• Microbiota Transplant Therapy to Prevent HE Recurrence in Veterans with Cirrhosis

  A Phase 2B multi-center study tests using donor microbiota transplants to prevent hepatic encephalopathy from coming back in Veterans with cirrhosis.

  NIH research VA Veterans Administration Hospital · Richmond, United States · NIH-11299678

• Why some patients with cirrhosis miss recommended liver cancer screening

  This project looks at why African American, Hispanic, and non-English-speaking patients with cirrhosis are less likely to get recommended liver cancer screening and how the COVID-19 pandemic changed that.

  NIH research Palo Alto Veterans Instit for Research · Palo Alto, United States · NIH-11224053

• Surgery risk calculator for people with cirrhosis

  Building a calculator that estimates the chance of death and complications after surgery for people who have cirrhosis.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11193256

• Liver cirrhosis network coordinating treatments and patient data

  This program brings hospitals together to run and organize tests of treatments and care approaches for people living with liver cirrhosis.

  NIH research Northwestern University · Chicago, United States · NIH-11180469

• EGCG as a safe, preventive approach to reduce liver cancer risk in cirrhosis

  Aiming to see if a green tea compound (EGCG) can safely lower the chance of liver cancer developing in people with cirrhosis.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11179209

• Using statins to lower liver cancer risk in people with cirrhosis by changing a blood protein signature

  This project will see if statins can change a blood protein signature and reduce the chance of liver cancer in people with cirrhosis.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11179201

Related topics

Quick answers

How many Cirrhosis clinical trials are recruiting right now?

78, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 27 countries. The most sites are in United States (26 trials), France (16 trials), China (14 trials), India (6 trials), Hong Kong (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 4: 6, Phase 3: 3, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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