Condition

Acute Heart Failure (AHF) clinical trials and research

• 20Clinical trials
• 13Countries

Newest Acute Heart Failure (AHF) clinical trials

All recruiting trials (20)

• Comprehensive clinical rule to diagnose acute heart failure in the emergency department

  A prospective study tests a combined clinical rule using patient data, a point-of-care NT-proBNP test, an 8-point lung ultrasound, and bedside echo to quickly diagnose acute heart failure in adults with new or worsening symptoms.

  Recruiting Chinese University of Hong Kong · Hong Kong and 2 other locations · NCT07754084

• Disrupted congestion in acute heart failure: can ultrasound at discharge predict readmission and death

  This study tests whether ultrasound checks of congestion at discharge can predict which patients with acute heart failure are more likely to be readmitted or die within 90 days.

  Recruiting University of Aarhus · Aarhus and 2 other locations · NCT07682298

• Pre-discharge Flu Vaccine for patients with acute heart problems

  This trial tests whether giving an influenza vaccine within 24 hours before hospital discharge helps patients who were treated for acute heart issues stay healthier this season.

  Recruiting Phase 4 Wroclaw Medical University · Wroclaw · NCT07617376

• Acute Heart Failure: How a Quantitative ECG Helps Clinicians

  This study tests whether quantitative ECG (QCG) measurements can reveal useful patterns in adults hospitalized with acute heart failure.

  Recruiting Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT07601022

• Urinary Sodium and Chloride Changes and Fluid Overload in Acute Heart Failure

  This study tests whether tracking urinary sodium and chloride during hospitalization can reflect congestion removal and predict short-term outcomes in adults with acute heart failure treated with IV diuretics.

  Recruiting Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · Olot, Girona and 3 other locations · NCT07597512

• Training medical residents to use the Venous Excess Ultrasound (VExUS) score for bedside volume assessment

  This project tests whether in-person or remote training better teaches medical residents to use the VExUS ultrasound score for bedside volume checks in patients with acute heart failure.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT07541768

• Sarcopenia in older adults with acute heart failure: using muscle ultrasound and biomarkers to predict outcomes

  This study tests whether measuring muscle mass with ultrasound, along with muscle strength and biomarkers, can help predict outcomes for adults 80 and older hospitalized for acute heart failure with preserved ejection fraction.

  Recruiting Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · Madrid, Madrid · NCT07530029

• Prolonged nasogastric ketone infusion for decompensated heart failure

  This will test whether a continuous nasogastric infusion of a ketone (D‑beta‑hydroxybutyrate) can safely reach target blood levels in adults with severely reduced ejection fraction admitted for acute decompensated heart failure or cardiogenic shock.

  Recruiting Phase 4 Institute for Clinical and Experimental Medicine · Prague, Prague · NCT07527156

• Multimodal profiling of adults hospitalized with acute heart failure and cardiogenic shock

  This project will test whether combining routine hospital data with extra blood and urine samples can help doctors identify types of cardiogenic shock and predict 30-day outcomes in adults hospitalized with acute heart failure.

  Recruiting at 4 sites University Heart Center Freiburg - Bad Krozingen · Bad Krozingen and 3 other locations · NCT07515508

• Screening for blood clots in adults with acute heart failure

  This trial tests whether a guideline-based screening approach can detect pulmonary embolism in adults admitted with acute heart failure.

  Recruiting University Hospital, Angers · Agen and 9 other locations · NCT07499661

• ReDS-guided decongestion for people hospitalized with heart failure

  This test will see if using a ReDS chest sensor to guide fluid removal helps adults hospitalized for heart failure have fewer heart-related problems in the month after discharge.

  Recruiting at 11 sites Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · Madrid, Madrid and 24 other locations · NCT07484009

• Fibroscan use to help diagnose acute heart failure in the emergency department

  This study tests whether a FibroScan device can quickly help doctors identify acute heart failure in adults who come to the ED with sudden shortness of breath.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07449377

• Restrictive versus liberal fluid intake for patients hospitalized with acute heart failure

  This study will try whether a thirst-driven, liberal drinking plan works as well as a fluid-restriction plan for adults hospitalized with acute decompensated heart failure.

  Recruiting Gødstrup Hospital · Herning · NCT07400991

• Low-dose digoxin after an episode of acute heart failure

  This study tests whether adding low-dose digoxin to standard heart failure medicines helps adults with reduced ejection fraction who recently stabilized after hospitalization feel better and be 'Alive and Well' at 180 days.

  Recruiting Phase 4 Hospital General de Agudos "Dr. Cosme Argerich" · Buenos Aires, Buenos Aires F.D. · NCT07321509

• Using urine sodium to guide IV diuretic dosing for hospitalized acute heart failure

  This trial will test whether increasing IV diuretic doses to reach higher urine sodium levels helps hospitalized adults with acute decompensated heart failure remove more salt and fluid and have fewer readmissions.

  Recruiting Phase 4 Lakeland Regional Health Systems, Inc. · Lakeland, Florida · NCT07263035

• Temporary heart support with the iVAC 2L device during high-risk coronary procedures

  This trial will try the iVAC 2L temporary heart‑support device during high‑risk PCI to help people with severe coronary artery disease stay hemodynamically stable through the procedure.

  Recruiting National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Moscow · NCT07149714

• Urine-based algorithm to personalize diuretics for fluid relief in acute heart failure

  This will test whether a urine-composition algorithm can guide IV diuretics to help adults hospitalized with acute heart failure remove excess fluid more effectively.

  Recruiting at 2 sites Wroclaw Medical University · Wroclaw, Dolnosląskie and 1 other locations · NCT07099885

• Evaluating residual congestion in patients with acute heart failure at discharge

  This study is testing new ways to check for leftover fluid in patients with acute heart failure when they leave the hospital to see if it can help predict their recovery better.

  Recruiting Consorci Sanitari Integral · Sant Joan Despí, Barcelona · NCT06993220

• Using ketone supplements to treat patients with acute heart failure

  This study is testing if a ketone supplement can help people in the hospital with acute heart failure feel better and improve their heart function compared to a placebo.

  Recruiting at 5 sites Phase 2 University of Aarhus · Aalborg and 7 other locations · NCT06653725

• Vietnamese rapid protocol to speed up the four main heart-failure medicines for people with reduced ejection fraction

  This program tests whether starting and quickly increasing the four key heart-failure medicines before discharge and during early outpatient follow-up helps adults hospitalized with reduced ejection fraction and high NT‑proBNP.

  Recruiting University Medical Center Ho Chi Minh City (UMC) · Long Xuyen, An Giang and 3 other locations · NCT06595290

Related topics

Quick answers

How many Acute Heart Failure (AHF) clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in Spain (4 trials), Denmark (3 trials), France (2 trials), Poland (2 trials), Argentina (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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