Spatial multi-omics and AI-based early warning for pancreatic cancer cachexia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study in adults with pathologically confirmed pancreatic ductal adenocarcinoma designed to explore the spatial distribution of omics data and its relation to cachexia. It will collect baseline questionnaires, imaging, and biological samples, and compare cachexia patterns between surgical and advanced patient cohorts. The goal is to build a high-precision multimodal AI model to detect cachexia early and to describe differences in cachexia incidence and progression across subgroups. The study does not assign an intervention and focuses on understanding mechanisms and developing a predictive framework. Eligibility includes adults with PDAC, adequate organ function, and an ECOG 0-2 or KPS ≥60, with informed consent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with pathologically confirmed pancreatic ductal adenocarcinoma.
* Aged ≥18 years with an expected survival time of ≥1 month (to be assessed for the advanced cohort). Assessment criteria: Comprehensive evaluation based on the patient's radiological tumor burden, vital organ function and physical status. Specific quantitative indicators: Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2, or Karnofsky Performance Status (KPS) score of ≥60. For patients in the advanced cohort, the assessment shall be jointly confirmed by two attending physicians with the professional title of associate chief physician or above in combination with radiological examination results.
* Voluntarily sign the informed consent form.

Exclusion Criteria:

* Complicated with other untreated malignant tumors or severe mental disorders.
* Pregnant women or patients unable to cooperate with follow-up.

Where it's running

• Peking Union Medical College Hospital
  Beijing, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.