Using CytoSorb device for patients with acute on chronic liver failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of the CytoSorb hemoadsorption device on bilirubin and ammonia levels in patients with acute on chronic liver failure (ACLF) grades 2 and 3. It aims to assess the prevalence and development of sarcopenia through ultrasound imaging of muscle mass and handgrip strength measurements. The study will compare these outcomes in patients receiving standard medical care with and without the CytoSorb device. Additionally, it will evaluate the reliability of ultrasound in quantifying muscle mass in chronic liver disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* adult patients (≥ 18 years) admitted to the University Hospital of Antwerp (UZA), Belgium.

  * Written informed consent from patient or if not possible due to encephalopathy (\> grade 2): legal representative
  * acute-on-chronic liver failure (ACLF) grade ≥ 2:

    * Acute decompensation event (identifiable trigger)
    * Hepatic encephalopathy grade ≥ 2
    * Acute kidney injury (AKI) according to Kidney Disease: Improving Global Outcome (KDIGO) criteria stage 3 (≥ 3-fold increase of serum creatinine OR increase of serum creatinine to ≥ 4 mg/dl OR urine output ≤ 0.3 ml/kg/h for ≥ 24 hours OR anuria for ≥ 12 hours)
    * Serum bilirubin ≥ 10 mg/dl
    * Hemodynamic instability with vasopressor support (norepinephrine \> 0.05 mcg/kg/min)

Exclusion Criteria:

* • known patient will against participation in the study or against the measures applied in the study

  * a decision made prior to inclusion to stop further treatment of the patient within the next 24 hours
  * no complete remission of malignancy including hepatocellular carcinoma within the past 12 months
  * ongoing intermittent or CRRT before study inclusion

Where it's running

• Uza
  Edegem, Antwerp, Belgium Recruiting

Study contacts

• Principal investigator: Karolien Dams — University Hospital, Antwerp
• Study coordinator: Karolien Dams
• Email: Karolien.Dams@uza.be
• Phone: +3238215175

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.