Understanding muscle loss in patients with inflammatory bowel disease
Official title: Prevalence and Impact of Sarcopenia in Patients With Inflammatory Bowel Disease and the Significance of Removing the Colon
Run by Sahlgrenska University Hospital · NCT06300541 · Data updated 2026-11-12
This study looks at how muscle loss affects people with severe flare-ups of inflammatory bowel disease, comparing those who get medical treatment to those who have surgery, to see how their muscle health changes over a year.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 180 (estimated) |
| Sponsor | Sahlgrenska University Hospital Academic / other |
| Locations | 1 site (Gothenburg) |
| Status | Recruiting |
| Started | April 1, 2021 |
| Main results expected | May 1, 2027 |
| Study ends | December 1, 2027 |
| Registry record updated | March 8, 2024 |
| Trial ID | NCT06300541 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult patients experiencing an acute flare-up of ulcerative colitis or Crohn's disease admitted to hospitals in the Region Västra Götaland and Stockholm.
✕Probably not a fit
Patients who are not experiencing a flare-up or those who do not wish to participate in the study will not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the prevalence of sarcopenia, a condition characterized by muscle loss, in patients suffering from severe flare-ups of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. Participants will be divided into two cohorts: one receiving medical treatment and the other undergoing colectomy. Evaluations will include examinations, laboratory tests, and surveys conducted at the onset of the flare-up and again one year later to assess changes in nutritional status and microbiota composition. The study seeks to understand the impact of these conditions on muscle health and overall prognosis.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with inflammatory bowel disease, potentially enhancing their nutritional status and overall health outcomes.
How similar studies have gone: While the specific focus on sarcopenia in inflammatory bowel disease may be novel, related studies have shown that addressing muscle loss in chronic conditions can lead to improved patient outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adult patients experiencing an acute flare-up of their bowel disease (ulcerative colitis or Crohn's disease) admitted to a hospital in the Region Västra Götaland and Stockholm are invited to participate in the study. Exclusion Criteria: * Not wishing to participate in the study Inability to understand the language or study procedures
Where it's running
-
Sahlgrenska University Hospital
Gothenburg, Sweden Recruiting
Study contacts
- Principal investigator: Jonas Varkey, MD. Ph D — Sahlgrenska University Hospital
- Study coordinator: Jonas Varkey, MD, PhD
- Email: jonas.varkey@vgregion.se
- Phone: 0046764030388
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.