How TIPS may improve muscle loss in cirrhosis and the role of FGF21

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with cirrhosis undergoing TIPS will be followed and divided into groups based on whether their sarcopenia improves after the procedure. Blood samples will be collected over time to measure serum FGF21 while imaging and functional tests will track muscle mass, strength, and performance. The study will compare changes in FGF21 and clinical muscle measures between patients who improve and those who do not. The combined value of FGF21 and muscle function indicators will be analyzed for predicting outcomes after TIPS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Diagnosed with liver cirrhosis and needing TIPS surgical treatment;
2. Aged between 18-80 years old;
3. Able to understand and sign the informed consent form and willing to cooperate in completing the examinations and follow-up visits.

Exclusion Criteria:

1. Combination of serious cardiovascular and cerebrovascular diseases (such as acute myocardial infarction, severe heart failure, etc.);
2. Suffering from malignant tumors and in the active stage;
3. Recent (within 3 months) history of major surgeries or traumas;
4. The presence of mental illness or cognitive disorders, which are unable to cooperate with the study;
5. Undergoing other special treatments that may affect the results of the study (such as certain specific immune-suppressing agents, hormones, etc.)

Where it's running

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
  Wuhan, Taiwan Recruiting

Study contacts

• Study coordinator: Jiacheng Liu Dr.
• Email: 1946046224@qq.com
• Phone: 18627162379

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• TIPS procedure with or without oral branched-chain amino acids (BCAA)

  This test will try giving oral BCAA supplements for three months after TIPS in adults with cirrhosis and sarcopenia to see if it improves muscle and clinical outcomes.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan · NCT07281846

• Prehab and Creatine/Whey Supplements in Cirrhosis-Related Frailty

  This study tests whether a digital prehabilitation app plus creatine and whey protein can help maintain muscle health in people with cirrhosis and frailty.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07029243

• Assessing muscle mass and strength in patients with cirrhosis

  This study is testing how muscle mass and strength change in people with cirrhosis to see how it affects their daily lives and health.

  Recruiting University Hospital, Antwerp · Edegem, Antwerpen · NCT06345547

• Exploring muscle composition's impact on liver transplant outcomes

  This study is testing how muscle health affects the success of liver transplants in patients with severe liver disease.

  Recruiting Mayo Clinic · Phoenix, Arizona · NCT05477277

• Endovascular treatment outcomes after portal hypertension–related GI bleeding in cirrhosis

  This study tests how well endovascular procedures for portal hypertension–related GI bleeding work in adults with cirrhosis, and what factors predict outcomes.

  Recruiting University Medical Center Ho Chi Minh City (UMC) · Ho Chi Minh City · NCT07918378

• Sarcopenia in Patients After Cardiac Surgery

  This observational study tests how common sarcopenia is after cardiac surgery and whether current care helps improve muscle mass and function.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07908472

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.