Blood Flow Restriction Walking for stroke-related sarcopenia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized, sham-controlled trial, chronic stroke patients with sarcopenia will perform walking with blood flow restriction or a sham version to see if the intervention improves muscle strength and physical performance. Secondary outcomes will explore possible changes in muscle mass, vascular function, and quality of life. Eligibility requires chronic stroke status and sarcopenia defined by AWGS 2025 criteria. The Hong Kong Polytechnic University leads the trial in Hong Kong.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with chronic stroke (≥6 months post-stroke)
* Sarcopenia will be diagnosed using the Asian Working Group for Sarcopenia (AWGS) 2025 criteria, defined as the concurrent presence of low muscle strength and low appendicular skeletal muscle mass. Muscle strength will be assessed using handgrip strength measured on the non-paretic side. Low muscle strength will be defined as handgrip strength \<28 kg for men and \<18 kg for women aged ≥65 years, and \<34 kg for men and \<20 kg for women aged 50-64 years. Appendicular skeletal muscle mass will be measured using bioelectrical impedance analysis, and the appendicular skeletal muscle mass index will be calculated as appendicular skeletal muscle mass divided by height squared. Low muscle mass will be defined as an appendicular skeletal muscle mass index \<7.0 kg/m² for men and \<5.7 kg/m² for women aged ≥65 years, and \<7.6 kg/m² for men and \<5.7 kg/m² for women aged 50-64 years.

Exclusion Criteria:

* Stroke occurred within the past 6 months
* Resting systolic blood pressure \> 200 mmHg
* Resting diastolic blood pressure \> 100 mmHg
* Presence of implanted electronic or metallic devices that interfere with blood flow restriction cuffs
* Contraindication to bioelectrical impedance analysis (e.g., pacemaker, ICD)

Where it's running

• Hong Kong Polytechnic University
  Hung Hom, Kowloon, Hong Kong Recruiting
• Hong Kong Polytechnic University
  Hung Hom, Kowloon, Hong Kong Not yet recruiting

Study contacts

• Study coordinator: Yingxiu Diao, Master
• Email: 24039355r@connect.polyu.hk
• Phone: +8614796733917

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.