SMILE: Tracking muscle loss, metabolic health, and aging over time
Sarcopenia, Metabolic Diseases, and Integrated Aging Longitudinal Evaluation (SMILE)
This project will follow adults to see if combining clinical data, imaging, and blood/tissue samples can detect and track muscle loss and metabolic changes linked to aging.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | RenJi Hospital Academic / other |
| Locations | 1 site (Shanghai) |
| Trial ID | NCT07205510 on ClinicalTrials.gov |
What this trial studies
SMILE is an ambispective cohort that combines retrospective records with prospective follow-up to map the pathological axis linking sarcopenia, metabolic disorders, and aging. The platform collects multimodal data including demographics, lifestyle factors, clinical phenotypes, laboratory tests, medical imaging, and biospecimens. Researchers will use these data to identify early signs of muscle aging, patterns connecting metabolic disease and sarcopenia, and predictors of adverse outcomes such as disability and mortality. The work is based at RenJi Hospital, Shanghai Jiaotong University, with adults aged 18 and over eligible to participate.
Who should consider this trial
Good fit: Adults aged 18 or older who can give informed consent and participate in clinic visits and assessments are the intended participants.
Not a fit: People who cannot consent, are unconscious, have severe mental illness preventing communication, or have conditions that would confound assessments are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the platform could enable earlier detection of muscle and metabolic decline and guide interventions to reduce falls, disability, and premature death.
How similar studies have performed: Prior cohort studies have linked sarcopenia with metabolic and cardiovascular risk, but large ambispective, multimodal platforms like SMILE are relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Adults aged 18 and over Exclusion Criteria: 1. Does not cooperate in signing the informed consent form; 2. Does not possess legal capacity; 3. In a state of loss of consciousness; 4. Suffering from severe mental illness, unable to communicate normally; 5. The researcher believes that the subject has a disease that affects the assessment of results and is unsuitable for inclusion.
Where this trial is running
Shanghai
- Department of Geriatrics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. — Shanghai, China (Recruiting)
Study contacts
- Study coordinator: 融 黄, Ph.D
- Email: 11084@renji.com
- Phone: +862168383816
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.