Muscle Health Endotypes in Childhood Cancer Survivors
Official title: Muscle Aging Phenotypes in Childhood Cancer Survivors
Run by St. Jude Children's Research Hospital · NCT07531498 · Data updated 2026-11-12
This study tests whether adult survivors of childhood cancer have different muscle health endotypes using advanced imaging and neuromuscular testing to guide future targeted interventions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 533 (estimated) |
| Sponsor | St. Jude Children's Research Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Memphis, Tennessee) |
| Status | Recruiting |
| Started | September 14, 2026 |
| Main results expected | May 2030 |
| Study ends | May 2031 |
| Registry record updated | September 16, 2026 |
| Trial ID | NCT07531498 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) who are part of the St. Jude Lifetime Cohort and have varying muscle health status, including survivors with reduced muscle mass/strength and non-survivor controls.
✕Probably not a fit
Some participants may not experience direct benefit if muscle health determinants are not modifiable by future interventions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
An observational study to characterize distinct muscle health endotypes in adult survivors of childhood cancer. Participants will undergo multimodal MRI and spectroscopy, nerve conduction studies, surface electromyography, body composition assessment, and physical performance testing in a single study visit within an ongoing cohort. The goal is to identify biological mechanisms behind reduced muscle mass and strength to inform precision interventions for preserving function and long-term health.
Why it matters
Potential benefit: Identifying mechanistic endotypes could enable more targeted strategies to preserve or improve muscle health in survivors.
How similar studies have gone: Previous work in cancer survivor cohorts has shown that multiple muscle-health phenotypes exist, but this study aims to define distinct endotypes using integrated imaging and neuromuscular assessments.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years old or older at time of consent and enrolled in SJLIFE. * Participant (100 per group for a total of 400) is/has: * Group 1: No cancer history * Group 2: Age and sex specific relative lean mass z-score of less than -0.5 OR age and sex specific hand grip or isokinetic (60 degrees/sec) quadriceps strength z-score of \<-0.5 AND exposure to a peripheral neurotoxin. * Group 3: Age and sex specific relative lean mass z-score of less than -0.5 OR age and sex specific hand grip or isokinetic (60 degrees/sec) quadriceps strength z-score of \<-0.5 AND NOT exposed to a peripheral neurotoxin. * Group 4: Age and sex specific relative lean mass z-score of less than -0.5 AND age and sex specific hand grip strength or isokinetic (60 degrees/sec) quadriceps strength z-score of \<-0.5 REGARDLESS of exposure status. * Participant or legal guardian is able and willing to give informed consent. Exclusion Criteria: * Presence of implanted medical devices or metal that would interfere with MRI or MRS. * Female Participant is pregnant. * Body weight exceeding 300 pounds, due to MRI restrictions. * Inability to lie flat on his/her back for 90 minutes or longer for MRI. * Inability or unwillingness of research participant or legal guardian/representative to give written informed consent. * Presence of known radiation-induced nerve injury. * Prescence of pre-existing neurologic (non-cancer related) or who develop chronic neurologic disorders (i.e. Charcot Marie Tooth Disease, Downs, congenital brain injury). * Participation on a lifestyle or medication clinical trial within the past 1 year.
Where it's running
-
St. Jude Children's Research Hospital
Memphis, Tennessee, United States Recruiting
Study contacts
- Principal investigator: Kirsten Ness, PhD — St. Jude Children's Research Hospital
- Study coordinator: Kirsten Ness, PhD
- Email: referralinfo@stjude.org
- Phone: 888-226-4343
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.