Using linoleic acid-rich oil to improve muscle strength in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial is designed to evaluate the effects of daily consumption of 12g of linoleic acid-rich oil on muscle strength, volume, fatigue resistance, and mobility in older adults with probable sarcopenia. Participants will be randomly assigned to receive either the linoleic acid supplementation or a placebo, allowing for a controlled comparison of outcomes. The study also aims to investigate the impact of this supplementation on mitochondrial function and cardiolipin species in skeletal muscle. By focusing on older adults, the trial addresses a critical aspect of aging and muscle health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Linoleic Acid Intake \<75% of the adequate intake
* Probable sarcopenia

Exclusion Criteria:

* Gastrointestinal diseases or disorders (including pancreatic and gastric bypass surgery) where consumption of the study foods would be contraindication or where the disease or disorder could negatively affect nutrient absorption and/or would prevent participants from tolerating the study foods
* Hyperthyroidism diagnosis
* Food Allergy or intolerances
* Any dietary restriction where consumption of the study foods or any ingredient would be contraindicated
* Unstable management of heart failure, heart disease events (including stroke or heart attack) within last 3 months prior to enrollment, a plan for heart surgeries or cardiac procedures
* Current or previous diagnosis of severe kidney failure, liver cirrhosis, other liver diseases/infections that cause liver damage and some pulmonary diseases or severe/uncontrolled pulmonary diseases
* Severe or uncontrolled rheumatologic or orthopedic diseases
* Current diagnosis of or current treatment of cancer other than non-melanoma skin cancer
* Neuromuscular or neurological conditions or diseases or use of mobility assistance (wheelchair, walker etc..) that would impact movement needed to perform the muscle function tests or prevent completion of the muscle function tests
* Use of mobility assistance (wheelchair, walker etc..) that would prevent completion of the muscle function tests
* Current use of supplements or medications for weight loss or following a weight loss program
* Use of supplements high in linoleic acid in the past 4 weeks prior to enrolling
* Pregnancy and lactation
* Alcohol or drug abuse
* Allergy/intolerance to lidocaine or similar medication
* Use of anticoagulant, antiplatelet, or other blood thinner medications
* Terminal Illness
* Any condition leading to muscle loss or weakness, impaired mobility or range of motion in legs (excluding normal aging)

Where it's running

• The Ohio State University
  Columbus, Ohio, United States Recruiting

Study contacts

• Principal investigator: Martha Belury, PhD RDN — Ohio State University
• Study coordinator: Martha Belury, PhD RDN
• Email: belury.1@osu.edu
• Phone: 614-292-1680

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Lower-limb rehabilitation robot training with nutrition education for sarcopenia

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.