Creatine with resistance training during GLP-1 therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot trial will enroll 40 adults beginning GLP-1 receptor agonist therapy for weight loss and randomize them to receive either creatine monohydrate or placebo while they participate in a 12‑week resistance‑training program. All participants will train three times per week and continue their GLP-1–based treatment. The goal is to see whether creatine can reduce loss of lean tissue and maintain functional performance during rapid weight loss. The study uses a placebo-controlled design to isolate the effect of creatine on muscle outcomes during combined therapy. Findings will inform whether creatine supplementation could support muscle health in patients starting GLP‑1–mediated weight loss.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Starting GLP-1 agonist therapy
* 18 years of age or older

Exclusion Criteria:

* Positive answers to a screening questionnaire for physical activity safety (the Get Active Questionnaire)

Where it's running

• University of Saskatchewan
  Saskatoon, SK - Saskatchewan, Canada Recruiting

Study contacts

• Principal investigator: Philip Chilibeck, PhD — University of Saskatchewan
• Study coordinator: Philip D Chilibeck, PhD
• Email: phil.chilibeck@usask.ca
• Phone: 306-966-1072

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.