Clinical trial Recruiting at 1 site Observational Ages 75 and up

Ultrasound to measure muscle quality and fat in older adults during rehab

Official title: Clinical Relevance of Matrix-based Ultrasound Assessment of Intramuscular Fat Infiltration in Hospitalized Older Adults (FATUS-OLD)

Run by Nantes University Hospital · NCT07411547 · Data updated 2026-11-12

We’re testing an ultrasound-based method to see if higher intramuscular fat at the start predicts poorer recovery in physical function for older adults 75+ undergoing rehab.

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Quick facts

Study typeObservational
Ages75 Years and up
SexAll
Enrollment115 (estimated)
SponsorNantes University Hospital
Academic / other
Drugs / interventionsradiation
Locations1 site (Nantes)
StatusRecruiting
StartedMay 21, 2026
Main results expectedNovember 21, 2028
Study endsNovember 21, 2028
Registry record updatedJune 25, 2026
Trial IDNCT07411547 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 75 and older hospitalized in a rehabilitation day-hospital program for gait or balance issues who can provide informed consent.

Probably not a fit

Results may not apply to younger patients, those with moderate to severe neurocognitive disorders, or individuals unable to comply with study procedures.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses a CE-marked ultrasound device to quantify muscle volume and intramuscular fat in hospitalized older adults during a rehabilitation day-hospital program. The goal is to determine if baseline fat infiltration in muscles helps predict physical performance at 6 months, beyond muscle size alone. Measurements are taken at baseline and during follow-up, with outcomes including SPPB scores and events like falls or rehospitalization. The study is prospective, monocentric, open-label, and non-randomized, conducted at Nantes University Hospital. It aims to validate ultrasound-derived biomarkers of muscle quality in a real-world geriatric population.

Why it matters

Potential benefit: If successful, clinicians could use ultrasound biomarkers to better predict recovery and tailor interventions for older adults at risk of poor physical recovery.

How similar studies have gone: Previous work in this area suggests muscle quality measures can relate to outcomes, but this study explores a novel ultrasound multiparametric approach in a real-world geriatric setting.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age ≥ 75 years
* Hospitalized in rehabilitation day-hospital program
* Written informed consent

Exclusion Criteria:

* Moderate to severe neurocognitive disorders
* Inability to comply with study procedures

Where it's running

  • CHU de Nantes
    Nantes, France
    Recruiting

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.