NIH-funded research Sbir 2 grant

Assessing muscle health in older adults using electrical signals

Official title: Accurate and rapid assessment of sarcopenia in older adults through electrical impedance myography

Funded at Myolex, INC. · NIH-10668482 · Data updated 2026-11-12

This study is looking at a new, quick way to check the muscle health of older adults to help spot sarcopenia, which is when people lose muscle strength as they age, using a safe technique that sends small electrical currents through the muscles, so we can better support seniors in staying strong and independent.

More Sarcopenia research and trials

Quick facts

Grant typeSbir 2 grant
Study typeNIH-funded research
Funding institutionMyolex, INC.
NIH-funded
Lab location1 site (Brookline, UNITED STATES)
Project startAugust 1, 2022
Project endJuly 31, 2025
Funding year2023
Award (this year)$813,035
NIH project number5R44AG074840-02
Project IDNIH-10668482 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are older adults aged 21 and above who may be experiencing muscle weakness or physical limitations.

Less likely to help

Patients who are younger than 21 or do not have any muscle health concerns may not benefit from this research.

What this research studies

This research focuses on improving the assessment of muscle condition in older adults, particularly to identify sarcopenia, which is the age-related loss of muscle mass and strength. The study utilizes a technique called electrical impedance myography (EIM), which involves applying electrical currents to specific muscles to gather data on their condition. This method is designed to be quick and effective, providing healthcare providers with better tools to evaluate muscle health without the need for complex imaging technologies. By integrating machine learning, the research aims to enhance the accuracy of the assessments, ultimately helping to prevent falls and maintain independence in older adults.

Why it matters

Potential benefit: If successful, this research could lead to earlier detection and better management of sarcopenia, improving the quality of life for older adults.

How similar studies have gone: Previous studies have shown that electrical impedance myography is effective in assessing muscle conditions, indicating a promising approach for this research.

Where this research is happening

  • Myolex, INC.
    Brookline, United States
    Active

Researchers

  • Principal investigator: Dickinson, David P. — Myolex, INC.
  • Study coordinator: Dickinson, David P.

Related research

Other NIH-funded projects on the same topics.

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  • MiRNA roles in age-related muscle loss and NMJ health

    This project explores how small RNA molecules called miRNAs influence muscle aging and the neuromuscular junction in adults.

    NIH research University of Nebraska Lincoln · Lincoln, United States · NIH-11452282

  • Multiscale microgels delivering GDNF and agrin to help with sarcopenia

    Aimed at older adults with muscle loss, this project tests a new treatment that slowly releases biological factors to support nerve-muscle connections and improve strength when combined with or for people who can’t do intense resistance training.

    NIH research University of Kentucky · Lexington, United States · NIH-11451992

  • Frailty and sarcopenia in aging adults

    Aging adults, especially women, may develop frailty and muscle loss, and this project explores how muscle blood flow and inflammation relate to these conditions and to dementia and heart problems.

    NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11411368

  • High-field MRI to detect muscle changes in age-related muscle loss

    Very strong MRI scans will measure muscle quality, fat, and chemistry in older adults with sarcopenia.

    NIH research Massachusetts General Hospital · Boston, United States · NIH-11388325

  • LA-rich oil to help strong muscles as we age

    A study will test whether adding a linoleic acid–rich oil to the diet improves muscle strength and walking ability in older adults with sarcopenia.

    NIH research Ohio State University · Columbus, UNITED STATES · NIH-11372304

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.