Investigating how to improve muscle strength and energy in aging individuals
Official title: Coordinated mechanisms to rescue bioenergetics and sarcopenia in aging
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11105773 · Data updated 2026-11-12
This study is looking at how a specific treatment might help older adults keep their muscles strong and healthy, so they can stay active and independent as they age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 1, 2022 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $319,431 |
| NIH project number | 5R01AG078174-04 |
| Project ID | NIH-11105773 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing age-related muscle decline or sarcopenia.
✕Less likely to help
Patients who are not experiencing muscle decline or those with specific genetic myopathies may not benefit from this research.
What this research studies
This research explores the decline in muscle mass and strength that occurs with aging, which can lead to frailty and loss of independence. The study focuses on the effects of intermittent glucocorticoid treatment on muscle performance in older adults, aiming to understand how this approach can stimulate energy metabolism and muscle growth. By using animal models, the researchers are examining the mechanisms that link energy stimulation to muscle health, with the goal of translating these findings to human patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance muscle strength and overall health in older adults, potentially improving their quality of life.
How similar studies have gone: Previous research has shown promising results with similar approaches in animal models, indicating potential for success in human applications.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Quattrocelli, Mattia — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Quattrocelli, Mattia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.