Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Exploring muscle composition's impact on liver transplant outcomes

Official title: Adverse Outcomes and Mortality in Liver Transplant

Run by Mayo Clinic · NCT05477277 · Data updated 2026-11-12

This study is testing how muscle health affects the success of liver transplants in patients with severe liver disease.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorMayo Clinic
Academic / other
Locations1 site (Phoenix, Arizona)
StatusRecruiting
StartedNovember 2, 2022
Main results expectedDecember 31, 2026
Study endsDecember 31, 2027
Registry record updatedAugust 5, 2026
Trial IDNCT05477277 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults with end-stage liver disease who are being evaluated for liver transplantation and require an MRI as part of their assessment.

Probably not a fit

Patients who have contraindications to MRI will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study investigates the relationship between muscle composition, assessed through MRI-based Muscle Assessment Score (MAsS), and adverse outcomes in candidates for liver transplantation. It focuses on patients with end-stage liver disease, particularly examining the effects of sarcopenia and myosteatosis on transplant success and mortality. By utilizing advanced imaging techniques, the study aims to enhance understanding of body composition's role in liver health and transplant efficacy. The findings could lead to improved patient selection and management strategies for liver transplant candidates.

Why it matters

Potential benefit: If successful, this study could lead to better assessment and management of liver transplant candidates, potentially improving transplant outcomes and reducing mortality rates.

How similar studies have gone: Previous studies have shown promising results in using imaging techniques to assess body composition in liver disease, indicating that this approach may be effective.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. All patients with end-stage liver disease undergoing evaluation for liver transplantation
2. Patient clinically indicated for MRI during transplant candidacy evaluation
3. Adult

Exclusion Criteria:

1\. Contra indication to MRI

Where it's running

  • Mayo Clinic Arizona
    Phoenix, Arizona, United States
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.