Exploring muscle composition's impact on liver transplant outcomes
Official title: Adverse Outcomes and Mortality in Liver Transplant
Run by Mayo Clinic · NCT05477277 · Data updated 2026-11-12
This study is testing how muscle health affects the success of liver transplants in patients with severe liver disease.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Phoenix, Arizona) |
| Status | Recruiting |
| Started | November 2, 2022 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2027 |
| Registry record updated | August 5, 2026 |
| Trial ID | NCT05477277 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults with end-stage liver disease who are being evaluated for liver transplantation and require an MRI as part of their assessment.
✕Probably not a fit
Patients who have contraindications to MRI will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot study investigates the relationship between muscle composition, assessed through MRI-based Muscle Assessment Score (MAsS), and adverse outcomes in candidates for liver transplantation. It focuses on patients with end-stage liver disease, particularly examining the effects of sarcopenia and myosteatosis on transplant success and mortality. By utilizing advanced imaging techniques, the study aims to enhance understanding of body composition's role in liver health and transplant efficacy. The findings could lead to improved patient selection and management strategies for liver transplant candidates.
Why it matters
Potential benefit: If successful, this study could lead to better assessment and management of liver transplant candidates, potentially improving transplant outcomes and reducing mortality rates.
How similar studies have gone: Previous studies have shown promising results in using imaging techniques to assess body composition in liver disease, indicating that this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. All patients with end-stage liver disease undergoing evaluation for liver transplantation 2. Patient clinically indicated for MRI during transplant candidacy evaluation 3. Adult Exclusion Criteria: 1\. Contra indication to MRI
Where it's running
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Mayo Clinic Arizona
Phoenix, Arizona, United States Recruiting
Study contacts
- Principal investigator: Elizabet Carey, MD — Mayo Cinic
- Study coordinator: Latasha Bunkley
- Email: bunkley.latasha@mayo.edu
- Phone: 480.342.5756
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.