Exploring muscle composition's impact on liver transplant outcomes
Adverse Outcomes and Mortality in Liver Transplant
This study is testing how muscle health affects the success of liver transplants in patients with severe liver disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Phoenix, Arizona) |
| Trial ID | NCT05477277 on ClinicalTrials.gov |
What this trial studies
This pilot study investigates the relationship between muscle composition, assessed through MRI-based Muscle Assessment Score (MAsS), and adverse outcomes in candidates for liver transplantation. It focuses on patients with end-stage liver disease, particularly examining the effects of sarcopenia and myosteatosis on transplant success and mortality. By utilizing advanced imaging techniques, the study aims to enhance understanding of body composition's role in liver health and transplant efficacy. The findings could lead to improved patient selection and management strategies for liver transplant candidates.
Who should consider this trial
Good fit: Ideal candidates for this study are adults with end-stage liver disease who are being evaluated for liver transplantation and require an MRI as part of their assessment.
Not a fit: Patients who have contraindications to MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better assessment and management of liver transplant candidates, potentially improving transplant outcomes and reducing mortality rates.
How similar studies have performed: Previous studies have shown promising results in using imaging techniques to assess body composition in liver disease, indicating that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. All patients with end-stage liver disease undergoing evaluation for liver transplantation 2. Patient clinically indicated for MRI during transplant candidacy evaluation 3. Adult Exclusion Criteria: 1\. Contra indication to MRI
Where this trial is running
Phoenix, Arizona
- Mayo Clinic Arizona — Phoenix, Arizona, United States (Recruiting)
Study contacts
- Principal investigator: Elizabet Carey, MD — Mayo Cinic
- Study coordinator: Latasha Bunkley
- Email: bunkley.latasha@mayo.edu
- Phone: 480.342.5756
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.