Vitamin D maintenance plan after major surgery
Official title: Regime for Vitamin D Maintenance in Post-Operative Patients (D-ECISIVE) Randomized Controlled Trial
Run by Sengkang General Hospital · NCT06708741 · Data updated 2026-11-12
This trial will see if taking a monthly vitamin D dose instead of the usual maintenance schedule helps keep vitamin D levels and supports muscle recovery in adults (21–65) after major surgery.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 21 Years to 65 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Sengkang General Hospital Academic / other |
| Locations | 1 site (Singapore, Singapore) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | June 30, 2027 |
| Registry record updated | May 4, 2026 |
| Trial ID | NCT06708741 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 21–65 who underwent a major operation, are independently ambulatory, can provide consent, agree to take vitamin D supplements, and have 25-hydroxyvitamin D levels of 30–50 ng/mL at 4–6 weeks after surgery.
✕Probably not a fit
Patients with chronic kidney disease, hyperparathyroidism, prior kidney stones, non-ambulatory status, or known allergy to high-dose vitamin D are excluded and unlikely to gain benefit from this regimen.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized Phase 3 trial at Sengkang General Hospital in Singapore enrolling adults 21–65 who had major surgery and have serum 25-hydroxyvitamin D levels of 30–50 ng/mL at 4–6 weeks post-op. Participants will be randomized to a monthly high-dose oral vitamin D maintenance regimen versus standard-of-care maintenance, with periodic blood tests to track vitamin D levels and clinical measures of muscle function and recovery. Key exclusions include chronic kidney disease or end-stage renal failure, hyperparathyroidism, history of kidney stones, non-ambulatory status, and allergy to high-dose vitamin D formulations. The trial uses an FDA-approved vitamin D formulation supplied by a non-U.S. manufacturer and is sponsored by Sengkang General Hospital with industry collaboration.
Why it matters
Potential benefit: If successful, this could offer a simpler, less frequent vitamin D maintenance option that preserves vitamin D status and may improve muscle recovery after major surgery.
How similar studies have gone: High-dose vitamin D repletion has been used successfully in short prehabilitation programs to speed vitamin D recovery and support muscle gain, but monthly maintenance dosing after surgery has not been extensively tested in large randomized trials.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Serum 25-hydroxyvitamin D levels between 30-50ng/ml at 4-6 weeks after operation * aged 21-65 years * ability to provide informed consent * accepts to take vitamin D supplements post-operatively and * have their serum vitamin D levels checked periodically. Exclusion Criteria: * They have undergone minor procedures (Table code \<4a) * have a history of chronic kidney disease/end staged renal failure * have previous history of ureteric/kidney stones * known hyperparathyroidism * are non-ambulatory independently * have had known allergies to the commercially available high dose vitamin D formulations. * Vulnerable personnel would be excluded from the study
Where it's running
-
Sengkang General Hospital
Singapore, Singapore, Singapore Recruiting
Study contacts
- Principal investigator: Frederick H Koh, FRCS, PhD — Sengkang General Hospital
- Study coordinator: Frederick H Koh, FRCS, PhD
- Email: frederick.koh.h.x@singhealth.com.sg
- Phone: 6930 6000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Sarcopenia in Patients After Cardiac Surgery
This observational study tests how common sarcopenia is after cardiac surgery and whether current care helps improve muscle mass and function.
-
Bone marrow mesenchymal stem cell injection for sarcopenia
This study tests whether CG-BM1, a stem cell injection, can be safely given to adults with sarcopenia to see if it helps improve muscle health.
-
GLP-1 receptor agonist use and muscle health in adults with obesity without diabetes
This study tests whether GLP-1 receptor agonists affect muscle mass and strength in adults with obesity who don’t have diabetes.
-
Sarcopenia and Epidural Steroid Injections in Lumbar Spinal Stenosis
We’re testing how sarcopenia relates to pain, function, and quality of life after a routine interlaminar epidural steroid injection in people with lumbar spinal stenosis.
-
Using Multimodal Ultrasound to Check Muscle Mass in Metabolic Disease Patients
This study tests whether a multimodal ultrasound approach can accurately measure muscle mass in people with metabolic syndrome, obesity, sarcopenia, or type 2 diabetes.
-
Lower-limb rehabilitation robot training with nutrition education for sarcopenia
In adults aged 60 and older with sarcopenia, this study tests whether adding robot-assisted leg training to nutrition education can improve muscle mass and walking ability compared with usual care.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.