How frailty and chronic conditions influence each other and change over time
Official title: Age-related Conditions in the Context of Multimorbidity and Frailty: Relative Weight of Frailty in Determining the Course and Outcomes of Different Chronic Diseases and Viceversa
Run by IRCCS San Raffaele · NCT06324149 · Data updated 2026-11-12
This project will re-examine adults with frailty, muscle loss, or mild cognitive problems to try to see if frailty predicts how chronic diseases progress and which blood or imaging markers change.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | IRCCS San Raffaele Academic / other |
| Locations | 1 site (Milan) |
| Status | Recruiting |
| Started | March 7, 2024 |
| Main results expected | February 28, 2026 |
| Study ends | April 30, 2026 |
| Registry record updated | June 22, 2025 |
| Trial ID | NCT06324149 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 who previously took part in FRASNET or are patients with mild cognitive impairment or dementia followed at San Raffaele and who can provide written informed consent.
✕Probably not a fit
People with a life expectancy under six months, unstable acute illness, or who cannot provide informed consent are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational, longitudinal project will re-contact participants from the FRASNET cohort evaluated in 2016–2017 and re-evaluate them alongside patients with mild cognitive impairment or dementia followed at the San Raffaele Neurologic Unit. Participants will undergo multidimensional visits including questionnaires and scales, blood sampling, muscle and cardiac ultrasound, electrocardiogram, and bioelectrical impedance analysis. The goal is to map trajectories of frailty and sarcopenia and identify biomarkers and imaging features that relate frailty to the course and outcomes of other chronic diseases. No experimental treatments are given; analyses will focus on prognostic relationships and temporal ordering between conditions and frailty.
Why it matters
Potential benefit: If successful, the findings could help clinicians identify patients at higher risk of decline and target monitoring or support earlier to preserve function.
How similar studies have gone: Previous longitudinal cohort studies of frailty and sarcopenia have identified useful prognostic markers, so this approach builds on existing evidence rather than being entirely novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Having participated in the FRASNET study or being a patient with mild cognitive impairment or dementia followed up at the Neurologic Unit of the San Raffaele Hospital * Ability to sign written informed consent * \> 18 years old Exclusion Criteria: * Life expectancy \< 6 months * Unwillingness to participate in the study * Unstable clinical disease(for ex. serious acute pathologies)
Where it's running
-
San Raffaele Hospital
Milan, Italy Recruiting
Study contacts
- Study coordinator: Patrizia Rovere Querini, PhD, MD
- Email: rovere.patrizia@hsr.it
- Phone: +390226433065
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.