How frailty and chronic conditions influence each other and change over time
Age-related Conditions in the Context of Multimorbidity and Frailty: Relative Weight of Frailty in Determining the Course and Outcomes of Different Chronic Diseases and Viceversa
IRCCS San Raffaele · NCT06324149
This project will re-examine adults with frailty, muscle loss, or mild cognitive problems to try to see if frailty predicts how chronic diseases progress and which blood or imaging markers change.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | IRCCS San Raffaele (other) |
| Locations | 1 site (Milan) |
| Trial ID | NCT06324149 on ClinicalTrials.gov |
What this trial studies
This observational, longitudinal project will re-contact participants from the FRASNET cohort evaluated in 2016–2017 and re-evaluate them alongside patients with mild cognitive impairment or dementia followed at the San Raffaele Neurologic Unit. Participants will undergo multidimensional visits including questionnaires and scales, blood sampling, muscle and cardiac ultrasound, electrocardiogram, and bioelectrical impedance analysis. The goal is to map trajectories of frailty and sarcopenia and identify biomarkers and imaging features that relate frailty to the course and outcomes of other chronic diseases. No experimental treatments are given; analyses will focus on prognostic relationships and temporal ordering between conditions and frailty.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 who previously took part in FRASNET or are patients with mild cognitive impairment or dementia followed at San Raffaele and who can provide written informed consent.
Not a fit: People with a life expectancy under six months, unstable acute illness, or who cannot provide informed consent are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the findings could help clinicians identify patients at higher risk of decline and target monitoring or support earlier to preserve function.
How similar studies have performed: Previous longitudinal cohort studies of frailty and sarcopenia have identified useful prognostic markers, so this approach builds on existing evidence rather than being entirely novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Having participated in the FRASNET study or being a patient with mild cognitive impairment or dementia followed up at the Neurologic Unit of the San Raffaele Hospital * Ability to sign written informed consent * \> 18 years old Exclusion Criteria: * Life expectancy \< 6 months * Unwillingness to participate in the study * Unstable clinical disease(for ex. serious acute pathologies)
Where this trial is running
Milan
- San Raffaele Hospital — Milan, Italy (RECRUITING)
Study contacts
- Study coordinator: Patrizia Rovere Querini, PhD, MD
- Email: rovere.patrizia@hsr.it
- Phone: +390226433065
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Frailty, Sarcopenia