NIH-funded research R21 grant

How exercise and diet affect muscle loss in older adults with HIV

Official title: The Influence of Habitual Physical Activity and Diet in the Development of Sarcopenia Among Older Adults With HIV

Funded at University of Washington · NIH-10821495 · Data updated 2026-11-12

This study is looking at how staying active and eating well can help prevent muscle loss in older adults living with HIV, and it aims to find ways to keep your muscles strong as you age.

More Sarcopenia research and trials

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionUniversity of Washington
NIH-funded
Lab location1 site (Seattle, United States)
Project startApril 15, 2023
Project endDecember 31, 2025
Funding year2024
Award (this year)$193,461
NIH project number5R21AG082537-02
Project IDNIH-10821495 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are older adults aged 50 and above who are living with HIV and may be experiencing or at risk for sarcopenia.

Less likely to help

Patients who are not living with HIV or those who are younger than 50 years old may not benefit from this research.

What this research studies

This research investigates how regular physical activity and dietary habits influence the development of sarcopenia, a condition characterized by muscle loss, in older adults living with HIV. The study aims to identify the relationship between lifestyle factors and the onset of sarcopenia, which is particularly prevalent in this population. By examining these factors, the research seeks to develop effective interventions that can help prevent or mitigate muscle loss among older adults with HIV. Participants may be asked to engage in specific exercise regimens and dietary modifications to assess their impact on muscle health.

Why it matters

Potential benefit: If successful, this research could lead to improved strategies for preventing muscle loss in older adults with HIV, enhancing their quality of life and independence.

How similar studies have gone: Previous research has shown that lifestyle interventions, including exercise and dietary changes, can effectively reduce the risk of sarcopenia in older populations, suggesting a promising avenue for this study.

Where this research is happening

  • University of Washington
    Seattle, United States
    Active

Researchers

  • Principal investigator: Oliveira, Vitor — University of Washington
  • Study coordinator: Oliveira, Vitor

Related research

Other NIH-funded projects on the same topics.

  • Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis

    This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.

    NIH research University of California, San Francisco · San Francisco, United States · NIH-11644470

  • MiRNA roles in age-related muscle loss and NMJ health

    This project explores how small RNA molecules called miRNAs influence muscle aging and the neuromuscular junction in adults.

    NIH research University of Nebraska Lincoln · Lincoln, United States · NIH-11452282

  • Multiscale microgels delivering GDNF and agrin to help with sarcopenia

    Aimed at older adults with muscle loss, this project tests a new treatment that slowly releases biological factors to support nerve-muscle connections and improve strength when combined with or for people who can’t do intense resistance training.

    NIH research University of Kentucky · Lexington, United States · NIH-11451992

  • Frailty and sarcopenia in aging adults

    Aging adults, especially women, may develop frailty and muscle loss, and this project explores how muscle blood flow and inflammation relate to these conditions and to dementia and heart problems.

    NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11411368

  • High-field MRI to detect muscle changes in age-related muscle loss

    Very strong MRI scans will measure muscle quality, fat, and chemistry in older adults with sarcopenia.

    NIH research Massachusetts General Hospital · Boston, United States · NIH-11388325

  • LA-rich oil to help strong muscles as we age

    A study will test whether adding a linoleic acid–rich oil to the diet improves muscle strength and walking ability in older adults with sarcopenia.

    NIH research Ohio State University · Columbus, UNITED STATES · NIH-11372304

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.