Investigating protein changes in aging and muscle function

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines how changes to proteins in skeletal muscle contribute to muscle atrophy and dysfunction associated with aging. It aims to understand the molecular mechanisms behind age-related muscle decline, which is crucial for enhancing rehabilitation strategies for older adults at risk of mobility impairment. The research involves pre-clinical evidence gathering through interventions like fatiguing exercise and muscle biopsies to identify specific protein modifications that may lead to improved physical function in frail older adults.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults between the ages 18-35 or 65-80 years
* Healthy by self-report
* Willing to participate in all aspects of the study design including muscle biopsy, unilateral exercise, and physical activity monitoring
* Fluent in English (due to lack of translation services, it is not practical to conduct the study using a language other than English).

Exclusion Criteria:

* Orthopaedic limitation (severe knee osteoarthritis, prior joint replacement, etc.).
* Volunteer has dementia or related mental issues that potentially put the subject at risk as determined by prior diagnosis.
* Volunteer has known untreated endocrine disease (hypo/hyper thyroidism, Addison's Disease or Cushing's syndrome, etc.)
* Volunteer has untreated/poorly-controlled hypertension (stage 2, per American College of Cardiology \[\>140/90 mmHg\]).
* Volunteer has significant heart, liver, kidney or respiratory disease.
* Volunteer has diabetes (insulin dependent or non-insulin dependent).
* Volunteer has known coagulopathies.
* Volunteer has taken anabolic steroids in the prior six months.
* Volunteer has received treatment for cancer (other than effective Mohs Surgery for successful removal of basal cell or squamous cell carcinomas)
* Unexpected weight loss \>5kg is last 12 months
* Volunteer is an active smoker or quit within the last year.
* Volunteer has known current alcohol or drug use disorder (AUD; defined as binge drinking of \>4 days in the last month. Binge drinking is \>5 drinks for men and \>4 drinks for women, per occasion). Or, if a volunteer reports drinking in excess of "low risk" per NIAAA (\>7 drinks/week for men and \>3 drinks/day for women and \>14 drinks/week and \>4 drinks/day).
* Volunteer has a diagnosed neuromuscular disorder.
* Volunteer has allergy to lidocaine.

Where it's running

• University of Oregon
  Eugene, Oregon, United States Recruiting

Study contacts

• Principal investigator: Damien M Callahan, Ph.D. — University of Oregon
• Study coordinator: Damien M Callahan, Ph.D.
• Email: damienc@uoregon.edu
• Phone: 541-346-5040

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.