Investigating protein changes in aging and muscle function
Skeletal Muscle Myosin Binding Protein C in Fatigue and Aging
This study is trying to see how changes in muscle proteins affect strength and movement in older adults to help improve their recovery and mobility.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University of Oregon Academic / other |
| Locations | 1 site (Eugene, Oregon) |
| Trial ID | NCT05926219 on ClinicalTrials.gov |
What this trial studies
This study examines how changes to proteins in skeletal muscle contribute to muscle atrophy and dysfunction associated with aging. It aims to understand the molecular mechanisms behind age-related muscle decline, which is crucial for enhancing rehabilitation strategies for older adults at risk of mobility impairment. The research involves pre-clinical evidence gathering through interventions like fatiguing exercise and muscle biopsies to identify specific protein modifications that may lead to improved physical function in frail older adults.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18-35 or 65-80 who are willing to participate in all aspects of the study.
Not a fit: Patients with significant orthopedic limitations, untreated endocrine diseases, or severe chronic conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new strategies for improving physical function and mobility in older adults suffering from muscle weakness and frailty.
How similar studies have performed: While the specific approach of this study may be novel, previous research has indicated that understanding protein changes in muscle can lead to advancements in treating age-related muscle decline.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults between the ages 18-35 or 65-80 years * Healthy by self-report * Willing to participate in all aspects of the study design including muscle biopsy, unilateral exercise, and physical activity monitoring * Fluent in English (due to lack of translation services, it is not practical to conduct the study using a language other than English). Exclusion Criteria: * Orthopaedic limitation (severe knee osteoarthritis, prior joint replacement, etc.). * Volunteer has dementia or related mental issues that potentially put the subject at risk as determined by prior diagnosis. * Volunteer has known untreated endocrine disease (hypo/hyper thyroidism, Addison's Disease or Cushing's syndrome, etc.) * Volunteer has untreated/poorly-controlled hypertension (stage 2, per American College of Cardiology \[\>140/90 mmHg\]). * Volunteer has significant heart, liver, kidney or respiratory disease. * Volunteer has diabetes (insulin dependent or non-insulin dependent). * Volunteer has known coagulopathies. * Volunteer has taken anabolic steroids in the prior six months. * Volunteer has received treatment for cancer (other than effective Mohs Surgery for successful removal of basal cell or squamous cell carcinomas) * Unexpected weight loss \>5kg is last 12 months * Volunteer is an active smoker or quit within the last year. * Volunteer has known current alcohol or drug use disorder (AUD; defined as binge drinking of \>4 days in the last month. Binge drinking is \>5 drinks for men and \>4 drinks for women, per occasion). Or, if a volunteer reports drinking in excess of "low risk" per NIAAA (\>7 drinks/week for men and \>3 drinks/day for women and \>14 drinks/week and \>4 drinks/day). * Volunteer has a diagnosed neuromuscular disorder. * Volunteer has allergy to lidocaine.
Where this trial is running
Eugene, Oregon
- University of Oregon — Eugene, Oregon, United States (Recruiting)
Study contacts
- Principal investigator: Damien M Callahan, Ph.D. — University of Oregon
- Study coordinator: Damien M Callahan, Ph.D.
- Email: damienc@uoregon.edu
- Phone: 541-346-5040
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.