Multidisciplinary sarcopenia clinic to diagnose and treat muscle loss from COPD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Cleveland Clinic will conduct a prospective observational comparison of a multidisciplinary sarcopenia clinic versus standard ambulatory COPD clinics. Patients hospitalized for a COPD exacerbation with spirometry-confirmed COPD and CT evidence of low pectoralis muscle mass will be enrolled and matched by disease severity. A team including a pulmonologist, pharmacist, COPD nurse, and COPD coordinator will deliver evidence-based diagnostics and treatments targeting skeletal muscle loss. Participants will be followed for one year to compare changes in muscle mass and function, COPD exacerbations, hospital/ED visits, and mortality.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. COPD exacerbation as the primary cause for inpatient hospitalization OR secondary diagnosis of COPD exacerbation with acute respiratory failure as the primary diagnosis.
2. Patients must have CT (Computed Tomography) imaging performed during their admission and evidence of low skeletal muscle mass determined by CT imaging of the pectoralis muscle
3. Age \> 40 years old.
4. Spirometry diagnosed COPD with FEV1/FVC ratio \<0.70 with at least moderate obstruction (FEV1; forced expiratory volume in 1 second \<80%).
5. Patients must have smoked at least 10 pack years and may be current or former smokers.

Exclusion Criteria:

1. History of other comorbid lung disease (i.e. interstitial lung disease, asthma).
2. Currently being evaluated or already listed for lung transplant.
3. Active malignancy.
4. Significant comorbid end organ failure defined as congestive heart failure (ejection fraction\<40%), end stage renal disease requiring dialysis, or cirrhosis (based on radiologic imaging).

Where it's running

• Cleveland Clinic Foundation
  Cleveland, Ohio, United States Recruiting

Study contacts

• Principal investigator: Amy Attaway, MD — The Cleveland Clinic
• Study coordinator: Amy Attaway, MD
• Email: attawaa@ccf.org
• Phone: 216-445-2807

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.