Condition

Osteoporosis clinical trials and research

• 69Clinical trials
• 56NIH research projects
• 30Countries

Newest Osteoporosis clinical trials

All recruiting trials (69)

• Role of LH and hCG in adults being evaluated for endocrine disorders

  This study looks at whether levels of luteinizing hormone (LH) and hCG in adults undergoing endocrine evaluation relate to their disease presence and outcomes.

  Recruiting Copenhagen University Hospital at Herlev · Herlev · NCT07824102

• Can a blood marker called lumican reveal hidden fragility in postmenopausal osteoporosis

  This study tests whether serum lumican levels can help identify hidden fragility risk in postmenopausal women beyond what bone density shows.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Küçükçekmece, Istanbul · NCT07677072

• Functional Muscle-Bone Incongruity Index: A look at muscle strength and bone health in adults

  This observational study tests a composite FKUI score using handgrip strength and hip/spine bone density to see if it better reflects musculoskeletal health than each measure alone in adults undergoing routine DXA.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Küçükçekmece, Istanbul · NCT07677033

• Vessel-X Bone Filling Container System for Vertebral Augmentation

  A new minimally invasive vertebral augmentation approach tests the Vessel-X device to see if it safely improves pain and function in people with osteoporotic vertebral compression fractures.

  Recruiting at 2 sites National Defense Medical Center, Taiwan · Taipei and 1 other locations · NCT07665424

• Proximal Humerus Cortical Thickness in Post-Stroke Paresis

  This study tests whether measurements of the outer bone thickness of the upper arm (the humerus) on the paretic side after a stroke reflect regional bone loss and how well they agree with standard bone density tests.

  Recruiting Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Istanbul · NCT07651306

• People with Osteoporosis: See if Walk-BEST Gait Program Helps You Walk Safer

  This pilot study tests whether older adults with osteoporosis can use the Walk-BEST gait training with a wearable sensor to walk more safely and reduce fall risk.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT07621679

• AI-guided diagnosis for high-risk osteoporosis populations

  This pragmatic trial tests whether an artificial intelligence tool called VeriOsteo OP can help identify high-risk people for osteoporosis and guide clinical decisions.

  Recruiting at 3 sites Taichung Veterans General Hospital · Changhua and 2 other locations · NCT07620834

• MicroRNA and bone markers linked to response to romosozumab and abaloparatide in postmenopausal osteoporosis

  Researchers will test whether microRNA and other bone markers can predict how well postmenopausal women with osteoporosis respond to romosozumab and abaloparatide.

  Recruiting Istituto Auxologico Italiano · Miano, Lombardy and 1 other locations · NCT07616401

• Post-osteoporotic fracture exercise program

  Aimed at people with osteoporosis who recently had a fracture, the study tests group exercise classes to see if they are feasible and safe and could help bone health and physical function.

  Recruiting Western University, Canada · London, Ontario · NCT07595991

• Blocking RANKL with denosumab to protect ovarian follicles

  This trial will test whether giving denosumab, a drug that blocks RANKL, can help protect follicle development in women with infertility who are undergoing assisted reproduction.

  Recruiting Regionshospitalet Viborg, Skive · Skive, Midt Jylland · NCT07546552

• Bone mineral density in late pregnancy: singleton versus twin gestations

  This project tests whether women with twin pregnancies have different bone mineral density in the third trimester than women carrying one baby, using two questionnaires and REMS ultrasound densitometry.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT07508553

• Advanced imaging and AI for detecting and staging osteoporosis and osteoarthritis

  This project will see if an AI system can use routine X‑rays, CT, and MRI to accurately diagnose and stage osteoporosis and osteoarthritis in adults.

  Recruiting Peking University People's Hospital · Beijing · NCT07474571

• Health literacy and awareness about osteoporosis

  This project will see how well older adults (women 65+, men 70+) with or at risk for osteoporosis understand health information by having them complete a 32‑question Turkish health literacy questionnaire.

  Recruiting Bandırma Onyedi Eylül University · Balıkesir, Bandırma · NCT07419451

• Using REMS ultrasound to check bone density in children and teens with conditions that lower bone strength

  This project will test whether REMS, a radiation-free ultrasound method, can measure bone mineral density in children and adolescents aged 5–18 who have conditions that weaken their bones.

  Recruiting Meyer Children's Hospital IRCCS · Florence, Tuscany · NCT07412782

• Ibandronate vs. Zoledronic Acid After Denosumab: Is Either Equal for Postmenopausal Osteoporosis?

  In postmenopausal osteoporosis, this study tests whether intravenous ibandronate given after stopping denosumab works as well as zoledronic acid over a year.

  Recruiting Phase 4 National Taiwan University Hospital · Taipei · NCT07406685

• Face-to-face versus online versus standard education for people with osteoporosis

  This project will test whether in-person classes or an online education program help people aged 50 and older with osteoporosis manage their condition better than usual information.

  Recruiting at 6 sites University Hospital, Linkoeping · Gävle and 6 other locations · NCT07367776

• Epione-assisted introducer placement for percutaneous pelvic and spine procedures

  This will test whether the Epione device can help doctors place introducers during CT- or CBCT-guided percutaneous pelvic or spine procedures in adults.

  Recruiting at 3 sites Precision IO Group · San Diego, California and 2 other locations · NCT07325578

• Factors that shape osteoporosis care for frail older adults

  This project tries to find out what influences how doctors in Alsace treat osteoporosis in frail older adults by talking with physicians who have used a practical management guide.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07303166

• Virtual chiropractor-delivered rehabilitation after vertebral fracture

  This pilot will test whether a chiropractor-led online program called VIVA helps people over 50 with osteoporotic vertebral fractures manage pain, move more safely, and follow targeted exercises.

  Recruiting University of Waterloo · Waterloo, Ontario · NCT07288684

• Romosozumab and denosumab alone or together for postmenopausal osteoporosis

  This 6-month pilot tests whether cyclic romosozumab combined with denosumab improves bone density more than denosumab alone in postmenopausal women with osteoporosis.

  Recruiting Phase 4 National Taiwan University Hospital · Douliu, Taiwan · NCT07283887

• Step-down therapy to preserve spine bone density after long-term denosumab

  This test sees if switching to half-dose denosumab every six months plus a zoledronic acid infusion better preserves lumbar spine bone density in men and postmenopausal women aged 50–85 who have used denosumab for at least three years.

  Recruiting Phase 4 National Taiwan University Hospital · Douliu, Taiwan · NCT07281586

• Denosumab effects on muscle strength and insulin sensitivity

  This trial will test whether denosumab improves muscle strength and insulin sensitivity in postmenopausal women with osteoporosis and type 2 diabetes who are taking metformin.

  Recruiting Phase 4 Aarhus University Hospital · Aarhus · NCT07271771

• Comparing osteoporosis risk factors in people after stroke

  This project will see if stroke itself and related health factors lead to lower bone density in people aged 55–85 who had an ischemic or hemorrhagic stroke.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle · NCT07228611

• GLP-1 drug effects on muscle and bone during weight loss

  It tests whether GLP-1–based weight-loss medication (tirzepatide) plus a lifestyle program changes muscle and bone in adults 18–50 with obesity (BMI 30–40).

  Recruiting Phase 4 Pennington Biomedical Research Center · Baton Rouge, Louisiana and 1 other locations · NCT07154719

• Bone health measurements for people with kidney transplants, on dialysis, or with age-related bone loss

  This project will try using standard osteoporosis tests (BMD, TBS, VFA, and blood bone turnover markers) to check bone disease in adults on hemodialysis or after kidney transplant compared with people who have primary osteopenia/osteoporosis.

  Recruiting Grigore T. Popa University of Medicine and Pharmacy · Iași · NCT07141043

• Validating lab assays, IV catheter techniques, and devices for endocrine, cardiometabolic, and musculoskeletal conditions

  This project will test whether laboratory assays, IV catheter methods, and equipment give consistent, reliable results in adults with or without obesity-related, metabolic, or musculoskeletal conditions.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07083557

• Self‑questionnaire to spot rare genetic bone conditions in adults with osteoporosis

  This project tests whether a self‑administered questionnaire can help identify rare genetic bone diseases in adults with osteoporosis.

  Recruiting CHU de Quebec-Universite Laval · Québec, Quebec · NCT07067827

• Resting-state brain imaging in postmenopausal osteoporosis

  This project will use resting-state MRI scans, questionnaires, bone density testing, and blood tests to see if brain connectivity and bone-remodeling markers differ between postmenopausal women with osteoporosis (with and without fractures) and matched healthy postmenopausal volunteers.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07030205

• Using an osteoporotic fracture score to guide treatment for thoracic and lumbar spine fractures

  This study will try using the OF (osteoporotic fracture) score to help doctors decide between surgery and non-surgical care for older adults with painful thoracic or lumbar osteoporotic fractures.

  Recruiting at 3 sites AO Foundation, AO Spine · San Francisco, California and 14 other locations · NCT07027306

• Impact of circuit training on bone health in postmenopausal women

  This study tests if circuit training with dumbbells can help improve bone health in postmenopausal women who have low bone density and vitamin D deficiency.

  Recruiting Cairo University · Cairo · NCT06950463

• Examining orthorexia nervosa in postmenopausal women with osteoporosis

  This study is testing how healthy eating habits, known as orthorexia nervosa, might relate to bone health in postmenopausal women with osteoporosis compared to those without the condition.

  Recruiting Beylikduzu State Hospital · Istanbul · NCT06947213

• Dairy versus plant-based drinks to help bone health with strength training

  This test will compare drinking dairy milk, a protein-matched pea beverage, or an almond beverage after strength workouts to see which best helps bone health in postmenopausal women and men 50 and older.

  Recruiting University of Saskatchewan · Saskatoon, Saskatchewan · NCT06946316

• Comparing two treatment regimens for osteoporosis in postmenopausal women

  This study is testing two different treatment plans for osteoporosis in postmenopausal women to see which one helps improve bone strength and reduce the risk of fractures better.

  Recruiting Phase 4 National Taiwan University Hospital · Taipei · NCT06938152

• Epidemiological assessment of osteoporosis in elderly people in Shandong Province

  This study is trying to understand how common osteoporosis is among older people in Shandong Province and what factors might increase their risk.

  Recruiting The Second Hospital of Shandong University · Jinan, Shandong · NCT06915935

• Vitamin K2 supplementation for patients with low bone density and a specific gene variant

  This study is testing if taking vitamin K2 can help improve bone density in adults aged 40-75 with low bone density who have a specific gene variant.

  Recruiting S.lab (Soloways) · Novosibirsk · NCT06867952

• Collecting data on liver transplant patients and their bone health

  This study is trying to understand how liver transplants affect bone health in patients by looking at their bone mineral levels during check-ups.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06838702

• Osteoporosis Fracture Prevention (OPTIONS) program to support recovery after a broken hip or leg.

  This project tests whether a combined program of tailored exercise, healthy nutrition, and bone‑strengthening medicines with clinician decision support helps people 65+ who break a hip or leg recover in a skilled nursing facility and avoid future fractures.

  Recruiting at 2 sites Brigham and Women's Hospital · Baltimore, Maryland and 1 other locations · NCT06731608

• Evaluating Amorphous Calcium Carbonate in Postmenopausal Women

  This study is testing if a new form of calcium can help improve bone health in postmenopausal women, both on its own and when combined with another medication.

  Recruiting Universal Integrated Corp. · Kaohsiung City · NCT06728462

• Digital education for osteoporosis patients to see if it lowers fracture risk

  A digital education program for people over 65 with osteoporosis is being tested to see if it lowers fractures and improves medication use and quality of life compared with standard care.

  Recruiting Sahlgrenska University Hospital · Mölndal, Region Västra Götaland · NCT06603545

• Combining two medications for treating postmenopausal osteoporosis

  This study is testing whether combining two approved medications can help women over 45 with postmenopausal osteoporosis improve their bone health and lower their risk of fractures.

  Recruiting Phase 4 Massachusetts General Hospital · Boston, Massachusetts · NCT06558188

• Using blood cells to improve osteoporosis diagnosis and monitoring

  This study is testing if checking the health of certain blood cells can help doctors better diagnose and monitor osteoporosis in both men and women.

  Recruiting at 2 sites Istituto Ortopedico Rizzoli · Bologna and 1 other locations · NCT06551155

• Improving outcomes for patients with fragility fractures

  This study is testing if a new support program for older adults with recent bone fractures can help them recover better than standard care that just provides education.

  Recruiting at 23 sites University of Alabama at Birmingham · Birmingham, Alabama and 22 other locations · NCT06455085

• Comparing methods to measure bone density using CT scans

  This study tests new ways to measure bone density using CT scans to help people with osteoporosis get better diagnoses and care.

  Recruiting Istituto Ortopedico Rizzoli · Bologna, Bo and 1 other locations · NCT06454617

• AI detection of vertebral fractures on routine chest‑abdomen CT for men over 50

  This project will try AI software to find vertebral fractures on chest‑abdomen CT scans in men aged 50 and older who have CTs for reasons other than bone disease.

  Recruiting IRCCS San Raffaele · Milan, Italy · NCT06449742

• Improving osteoporosis care for older women

  This study is trying to find better ways to help older women with osteoporosis by working with both patients and doctors to create useful care guidelines.

  Recruiting Bradford Institute for Health Research · Bradford, West Yorkshire · NCT06431867

• How short steroid treatments change bone turnover markers in people with inflammatory joint disease

  This project will test whether short courses of glucocorticoids change blood bone-turnover tests in people with inflammatory joint disease who are not on osteoporosis therapy.

  Recruiting at 2 sites Diakonhjemmet Hospital · Drammen and 1 other locations · NCT06395883

• Probiotic and prebiotic combination to improve bone health in older women

  This study tests if a daily combination of probiotics and prebiotics can help improve bone health in older women over 18 months.

  Recruiting Hebrew SeniorLife · Roslindale, Massachusetts · NCT06389539

• Assessing fracture risk in post-menopausal women using BBCT-hip

  This study is testing a new method called BBCT-hip to see if it can accurately predict hip fracture risk in post-menopausal women based on their height, weight, and CT scans.

  Recruiting at 2 sites Istituto Ortopedico Rizzoli · Bologna and 1 other locations · NCT06270758

• Effects of milk and yogurt on bone health and body composition in young adults

  This study tests whether drinking milk or eating yogurt can help young adults in Canada improve their bone health and body composition over two years.

  Recruiting University of Saskatchewan · Saskatoon, Saskatchewan · NCT06265246

• Using an osteoporosis medication to improve muscle health in older adults

  This study is testing if an osteoporosis medication called Denosumab can help frail older adults improve their muscle strength and reduce the risk of falls.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06118905

• Optimizing osteoporosis treatment with romosozumab and zoledronate

  This study is testing different ways to use two osteoporosis treatments, romosozumab and zoledronate, to see which combination helps postmenopausal women build stronger bones and lower their risk of fractures.

  Recruiting Phase 4 University of Aarhus · Aarhus · NCT06059222

• Impact of donepezil on bone health in Alzheimer's patients

  This study is testing if the medication donepezil can help improve bone health in people with Alzheimer's disease by looking at changes in bone density over a year.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT06041789

• Health Improvement Program for Osteoporosis in China

  This study is trying to find out how well a tool for predicting fracture risks works for people over 40 with osteoporosis in China, to help improve their treatment and care.

  Recruiting Second Xiangya Hospital of Central South University · Changsha, Hunan · NCT05906147

• Improving collaboration in osteoporosis treatment after hip fractures

  This study is testing if better teamwork between doctors can help older patients who have had a hip fracture get the right osteoporosis treatment to prevent more fractures.

  Recruiting University Hospital, Akershus · Lørenskog, Akershus · NCT05904353

• Surgeon-driven bone health referral for patients having lower limb joint replacement

  This study is testing if sending patients with osteoporosis to a bone health specialist before getting lower limb joint replacement surgery can help reduce fractures and complications compared to regular care.

  Recruiting Johns Hopkins University · Columbia, Maryland · NCT05845021

• Identifying factors that regulate bone health

  This study is trying to find out what factors affect bone health by looking at bone samples from patients having orthopedic surgeries to help improve treatments for conditions like osteoporosis and osteoarthritis.

  Recruiting at 4 sites Relation Therapeutics · London, Greater London and 7 other locations · NCT05732870

• Effects of Different Exercise Types on Bone Health in Older Veterans

  This study tests how different types of exercise, like lifting weights and running, can affect bone health in older veterans aged 60 to 80.

  Recruiting VA Office of Research and Development · Aurora, Colorado · NCT05266976

• Analyzing metabolic profiles of blood stem cells in older adults with clonal hematopoiesis

  This study is trying to see how aging affects blood stem cells in older adults with certain genetic changes, by looking at blood and bone marrow samples taken during hip surgery.

  Recruiting Imelda Hospital, Bonheiden · Bonheiden, België · NCT05246813

• Using AGN1 LOEP to treat osteoporosis in women

  This study is testing a new procedure called AGN1 LOEP to see if it can help postmenopausal women with osteoporosis build new bone in their hips.

  Recruiting AgNovos Healthcare, LLC · Sint-Niklaas, Antwerpen · NCT05202678

• Biobank for patients with inflammatory chronic diseases and osteoporosis

  This study is creating a biobank to collect samples from patients with chronic inflammatory diseases and osteoporosis to see if they can find markers that help doctors choose better treatments.

  Recruiting University Hospital, Toulouse · Toulouse · NCT05039216

• Preventing secondary hip fractures in postmenopausal women

  This study is testing if a new treatment can help prevent additional hip fractures in postmenopausal women who have already broken a hip and are having surgery to fix it.

  Recruiting at 48 sites AgNovos Healthcare, LLC · Innsbruck and 65 other locations · NCT04796350

• Analyzing bone damage in patients with osteoporosis and fragility fractures

  This study is testing how tiny changes in bones affect fracture risk in people with osteoporosis and fragility fractures who are having hip replacement surgery.

  Recruiting Politecnico di Milano · Miano, Milano · NCT04787679

• Preventing bone loss in critically ill adults using medications

  This study is testing if two medications can help prevent bone loss in critically ill adults over 50 who have been in the ICU for more than a day.

  Recruiting at 20 sites Phase 2 Australian and New Zealand Intensive Care Research Centre · Sydney, New South Wales and 21 other locations · NCT04608630

• Evaluating new treatments for osteoporosis after denosumab therapy in Japanese patients

  This study tests different treatment options for Japanese patients with osteoporosis who have been on denosumab for two years to see which one works best and is safe to use for another two years.

  Recruiting Phase 2 Shinshu University · Matsumoto, Nagano · NCT03755193

• China health screening using low-dose chest CT to measure spine bone density and body/liver fat

  This project uses low-dose chest CT scans and QCT to test whether spine bone density, visceral fat, and liver fat can be measured in adults getting routine health checks across China.

  Recruiting at 6 sites Beijing Jishuitan Hospital · Wuhu, Anhui and 5 other locations · NCT03699228

• Second hip fracture risk in Chinese patients with osteoporotic hip fractures

  This project will see if CT-based measurements of bone and muscle can predict second hip fractures in older adults who have already had an osteoporotic hip fracture.

  Recruiting Beijing Jishuitan Hospital · Beijing, Beijing Municipality · NCT03461237

• Cohort study on osteoporosis in China

  This study is trying to understand osteoporosis in middle-aged and older people in China by looking at their health habits and history through questionnaires and blood tests.

  Recruiting at 11 sites Shanghai University of Traditional Chinese Medicine · Shenzhen, Guangdong and 11 other locations · NCT02958020

• Understanding osteoporosis caused by glucocorticoids in patients with chronic inflammatory diseases or psoriasis

  This study is trying to gather information on osteoporosis caused by glucocorticoid treatment in people with chronic inflammatory diseases or psoriasis to better understand and manage this condition.

  Recruiting Charite University, Berlin, Germany · Berlin, State of Berlin · NCT02719314

• Fracture liaison and osteoporosis medication monitoring program at National Taiwan University Hospital

  This program tests whether a coordinated fracture liaison service plus a medication-monitoring service can help people aged 50+ with recent hip or spine fractures or on osteoporosis drugs stick with treatment and get appropriate follow-up.

  Recruiting National Taiwan University Hospital · Hsinchu · NCT02635022

NIH-funded research (newest 40 of 56)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Or olive-oil derived compound to prevent bone loss in women

  A safe, orally taken nutraceutical may help prevent osteoporosis in adult women by supporting bone formation and reducing bone loss.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11440446

• When to stop, switch, or pause long-term osteoporosis medicines for older adults

  This project looks at whether stopping, switching, or taking breaks from long-term osteoporosis drugs changes fracture risk and side effects for older adults.

  NIH research Brown University · Providence, United States · NIH-11410913

• Cortical Bone Mechanics Technology to better screen for osteoporosis

  A new noninvasive test called CBMT uses ulnar flexural rigidity to predict fracture risk better than standard bone density tests, helping adults who may be at risk for osteoporosis.

  NIH research Osteodx INC. · Athens, UNITED STATES · NIH-11405859

• Gene therapy for osteoporosis linked to ALDH2 deficiency in postmenopausal East Asian women

  A gene therapy approach is being developed to reduce osteoporosis risk in postmenopausal East Asian women who have ALDH2 deficiency and drink alcohol.

  NIH research Enyx Therapeutics, LLC · New York, United States · NIH-11402253

• Metabolomics clues to osteoporosis risk in diverse populations

  A study using small molecules in blood samples to understand osteoporosis risk, with a focus on aging, ethnicity, and sex differences.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11365802

• Single-Cell Study of Bone Cells to Understand Osteoporosis

  Researchers will study individual bone-related cells from people to uncover why aging leads to weaker bones and higher fracture risk.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11365798

• Gut bacteria and osteoporosis risk: what gut microbes may mean for your bone health

  A large study will look at how gut bacteria relate to bone density and fracture risk, with the goal of better understanding who is at risk and how to protect bones.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11365793

• Trans-omics approach to understand osteoporosis risk in people

  A large-scale human study to uncover how genes, the gut microbiome, and their interactions affect bone density and fracture risk in diverse groups.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11365772

• Preserving geriatric muscle with an osteoporosis medication

  A study tests whether a drug already approved for osteoporosis can help older adults maintain muscle strength and mobility to prevent falls.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11335601

• Lab-made ovarian implants to restore hormones and protect bone health in women

  Testing whether implanting lab-grown ovarian tissue can restore hormone balance and reduce bone loss in women with menopause or ovarian failure.

  NIH research Miami University Oxford · Oxford, United States · NIH-11332471

• Targeting antibodies to bone to treat osteoporosis

  A researcher team is testing bone-targeted antibodies to improve osteoporosis treatment by delivering medicine directly to bone.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11332431

• Osseosurface Electronics for Monitoring Bone Health in Osteoporosis

  A new battery-free, implantable bone sensor will provide real-time data about bone health in animal models to help develop better treatments for osteoporosis.

  NIH research University of Arizona · Tucson, United States · NIH-11321718

• Antibodies that neutralize oxidized fats to protect bone health

  This project will see if boosting natural antibodies that neutralize oxidized phospholipids can help prevent age-related bone loss and osteoporosis.

  NIH research Central Arkansas Veterans Hlthcare Sys · North Little Rock, United States · NIH-11264782

• Bone and muscle changes seen on chest CT in people with COPD

  Using chest CT scans and AI, researchers will look for patterns of bone loss and muscle weakness linked to COPD in people with and without the disease.

  NIH research University of Iowa · Iowa City, United States · NIH-11261204

• How bone cells called osteocytes respond to anabolic osteoporosis treatments

  This work looks at how bone-building osteoporosis drugs change osteocytes in postmenopausal women and in mice.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11260284

• Improving bone-building treatments for osteoporosis

  This center looks at how current bone-building medicines work and why their benefit decreases over time for people with osteoporosis.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11260277

• One-time gene therapy to prevent alcohol-related bone loss in ALDH2-deficient postmenopausal East Asian women

  A single IV gene therapy aims to restore the ALDH2 enzyme to lower toxic acetaldehyde and help prevent alcohol-related bone loss in postmenopausal East Asian women with ALDH2 mutations.

  NIH research Enyx Therapeutics, LLC · New York, United States · NIH-11256090

• Bone health, diet, and stress in Puerto Rico adults

  This project looks at how what adults in Puerto Rico eat, how much stress they have, and everyday habits relate to bone strength and osteoporosis risk.

  NIH research University of Massachusetts Lowell · Lowell, United States · NIH-11252554

• How high blood pressure may weaken bones and affect healing

  Researchers are working to help aging Veterans with high blood pressure keep bones stronger and heal fractures faster by boosting how parathyroid hormone builds bone.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11212764

• Understanding how nanoscale bone composition affects osteoporosis

  This study is looking at how the tiny structure of bone affects its strength in people with osteoporosis, and by providing bone samples, you can help us find better ways to diagnose and treat this condition.

  NIH research The Trustees of the Stevens Institute of Technology · Hoboken, United States · NIH-11212348

• Personalized osteoporosis care based on bone turnover

  This project will match osteoporosis treatments to adults with age-related low bone turnover so they can get the most helpful medicines.

  NIH research University of Kentucky · Lexington, United States · NIH-11178457

• Improving osteoporosis screening for older male veterans

  This study is looking at new ways to help older male veterans find out if they have osteoporosis, so they can get the right care to prevent fractures, and it will compare two different methods to see which one works best.

  NIH research Durham VA Medical Center · Durham, United States · NIH-11173552

• Long-term osteoporosis treatment strategies

  This project aims to find better ways to switch and combine osteoporosis medicines so older adults can lower their long-term fracture risk.

  NIH research Berkeley Madonna, INC. · Albany, UNITED STATES · NIH-11159522

• How frailty affects bone loss and broken bones in Veterans with rheumatoid arthritis

  This project looks at how being frail changes bone strength and the chance of broken bones in Veterans who have rheumatoid arthritis.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11132666

• Benefits and risks of long-term osteoporosis medicines, including taking breaks or switching drugs

  This project compares continuing, pausing, or switching osteoporosis medicines to see how each approach affects fracture risk and serious side effects in older adults.

  NIH research Brown University · Providence, United States · NIH-11131264

• Comparing Osteoporosis Medications for Safety and Effectiveness

  This project helps us understand which osteoporosis medications work best and are safest for people at risk of broken bones.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11129725

• Understanding Osteoporosis through Body Chemistry

  This project aims to find new ways to predict, diagnose, and treat osteoporosis by looking closely at the chemical makeup of our bodies, especially in older adults and different ethnic groups.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11118855

• Understanding Bone Cells to Fight Osteoporosis

  This project explores different types of bone cells to better understand osteoporosis and prevent fractures in older adults.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11118844

• Your Gut Bacteria and Osteoporosis Risk

  This project looks at how the bacteria in your gut might affect your risk of developing osteoporosis, a condition that weakens bones.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11118835

• Understanding Genes and Gut Health for Bone Weakness

  This project explores how our genes and gut bacteria work together to affect bone strength and the risk of osteoporosis.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11118815

• Developing a new way to measure bone health for osteoporosis treatments

  This study is looking at whether changes in bone density can help us find better and safer treatments for osteoporosis, so that patients can have more effective options to reduce their risk of fractures.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11087988

• Using an osteoporosis medication to help older adults maintain muscle health

  This study is looking at whether Denosumab, a medication for osteoporosis, can help older adults keep their muscles strong and stay active, which may lower their chances of falling or getting hurt.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11087486

• Improving Bone Strength for Older Adults

  This research looks for new ways to strengthen bones and prevent bone loss in older adults by focusing on specific body signals and a potential new treatment.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11086095

• Understanding how bone cells respond to osteoporosis treatments

  This study is looking at how bone cells called osteocytes react to treatments for osteoporosis in post-menopausal women, with the hope of finding better ways to strengthen bones and improve current therapies.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11085960

• Investigating new therapies to improve bone health in older adults

  This study is looking at ways to improve treatments for osteoporosis, a condition that affects many older adults by weakening bones, and it aims to find out why some current therapies stop working over time, so we can develop better options for patients like you.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11085953

• Understanding the genetics of osteoporosis and bone health

  This study is looking at how our genes might affect bone health and the risk of osteoporosis, so if you’re curious about what makes bones strong or weak, this research could help uncover important information!

  NIH research University of Virginia · Charlottesville, United States · NIH-11077680

• Using engineered ovarian tissue to help treat osteoporosis in women

  This study is exploring a new way to help women after menopause by using specially created ovarian tissues to balance hormones that support bone health, which could lower the chances of osteoporosis and fractures, offering a safer option than traditional hormone treatments.

  NIH research Miami University Oxford · Oxford, United States · NIH-11076819

• Developing wireless technology to monitor bone health for osteoporosis treatment

  This study is testing new wireless devices that can be placed in bones to keep track of bone health, helping to improve how we understand and treat osteoporosis.

  NIH research University of Arizona · Tucson, United States · NIH-11075305

• Investigating risk factors for bone health and osteoporosis in Puerto Rican adults

  This study is looking at how things like diet, stress, and culture affect bone health and osteoporosis in adults in Puerto Rico, so we can find better ways to help prevent this condition.

  NIH research University of Massachusetts Lowell · Lowell, United States · NIH-11066678

• Understanding bone and muscle changes in COPD patients

  This study is looking at how weak bones and muscles affect people with COPD by using special imaging and technology, and it aims to help doctors better understand and treat these issues in patients like you.

  NIH research University of Iowa · Iowa City, United States · NIH-11055630

Related topics

Quick answers

How many Osteoporosis clinical trials are recruiting right now?

69, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 30 countries. The most sites are in United States (12 trials), Italy (10 trials), Taiwan (8 trials), Canada (7 trials), Turkey (Türkiye) (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 9, Phase 2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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