Understanding muscle loss in men with prostate cancer receiving hormone therapy
Official title: SArcopenia in Men with Prostate Cancer undergoing ADT (SAP-ADT)
Funded at Seattle Inst for Biomedical/clinical Res · NIH-11010810 · Data updated 2026-11-12
This study is looking at how losing muscle mass and strength affects men with advanced prostate cancer who are receiving hormone therapy, and it aims to find ways to better support these patients over the next year.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Inst for Biomedical/clinical Res NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 12, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $583,926 |
| NIH project number | 5R01CA279220-02 |
| Project ID | NIH-11010810 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men diagnosed with advanced prostate cancer who are about to start androgen deprivation therapy.
✕Less likely to help
Patients with prostate cancer who are not undergoing androgen deprivation therapy or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the loss of muscle mass and function, known as sarcopenia, in men diagnosed with advanced prostate cancer who are undergoing androgen deprivation therapy (ADT). The study aims to identify clinical outcomes and predictors of sarcopenia, as well as the biological mechanisms involved, particularly focusing on mitochondrial function. Participants will be monitored over a 12-month period to assess changes in body composition and muscle strength, which could help improve treatment strategies for these patients.
Why it matters
Potential benefit: If successful, this research could lead to better management of sarcopenia in prostate cancer patients, improving their quality of life and treatment outcomes.
How similar studies have gone: Previous research has shown that addressing sarcopenia in cancer patients can lead to improved outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Seattle Inst for Biomedical/clinical Res
Seattle, United States Active
Researchers
- Principal investigator: Garcia, Jose M. — Seattle Inst for Biomedical/clinical Res
- Study coordinator: Garcia, Jose M.
Related research
Other NIH-funded projects on the same topics.
-
Muscle loss in men with prostate cancer on hormone therapy
This project will follow men starting androgen deprivation (hormone) therapy for prostate cancer to track muscle loss, strength, and quality of life over 12 months.
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-
Effects of ADT on motivation and emotion in prostate cancer patients
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Causal Protein Markers to Understand and Predict Prostate Cancer Risk in Africans and Europeans
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Ethical multimodal AI platform to improve prostate cancer detection with ultrasound
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.